Tissue specific functions of Early B-cell factor in cellular differentiation.

Research output: ThesisDoctoral Thesis (compilation)

Abstract

This work focus on the functions by which the transcription factor Early B-cell Factor (EBF) regulate gene expression in different cell types. To address this question, gene expression analyses aimed to investigate the regulatory role of EBF in neuroblastoma cells, B-lymphocytes, adipocytes and stromal cells were performed.

The addresses question is of crucial importantse for the understanding of basic concepts in the area of developmental biology, were a limited set of transcription factors are able to support the development of different cell types. This could be achieved by that different differentiation-pathways share vital target genes involved in differentiation in general, or that TFs act on different target genes in different tissues. This work strongly suggests that in the case of EBF, it is an issue of regulation of different target genes in different tissues. The work indicates that the mechanism by which this is achieved would be a combination of coordinated expression of co-factors and chromatin configuration.

Details

Authors
  • Anna Lagergren
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell and Molecular Biology

Keywords

  • transcription factor, extracellular fluids, Haematology, tissue specific, cellular differentiation, EBF, Hematologi, extracellulära vätskor
Original languageEnglish
QualificationDoctor
Awarding Institution
Supervisors/Assistant supervisor
Award date2006 Oct 2
Publisher
  • Lund Strategic Research Center for Stem Cell Biology and Cell Therapy
Print ISBNs91-85559-25-3
Publication statusPublished - 2006
Publication categoryResearch

Bibliographic note

Defence details Date: 2006-10-02 Time: 13:00 Place: Segerfalk lecture hall Wallenberg Neurosciense Center, Sölvegatan 19, Lund External reviewer(s) Name: Rothenberg, Ellen Title: Professor Affiliation: California Institute of Technology, Pasadena, CA --- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematopoietic Stem Cell Laboratory (013022012)