TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration

Research output: Contribution to journalArticle

Abstract

Russ et al. show that human astrocytes adopt different reactive immune phenotypes when exposed to either TNF-α or alpha-synuclein fibrils, which are exogenous stressors that compete to drive the astrocyte immune reactive response. They also show that PARK2-variant-containing astrocytes exhibit an exacerbated response to the stressors, accompanied by bioenergetic defects.

Details

Authors
Organisations
External organisations
  • H. Lundbeck A/S
  • François Jacob Institute of biology
  • Istituto Ortopedico Gaetano Pini
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell and Molecular Biology

Keywords

  • alpha-synuclein, astrocytes, HLA genes, iPSC, Parkinson's disease, reactivity
Original languageEnglish
Article number108895
JournalCell Reports
Volume34
Issue number12
Publication statusPublished - 2021
Publication categoryResearch
Peer-reviewedYes