Total Synthesis of Transtaganolide E and F: Insight in the Biosynthesis of the Transtaganolides

Research output: Contribution to journalArticle

Abstract

A total synthesis of transtaganolide E and F, proposed intermediates in the biosynthesis of the potent transtaganolides, including an Ireland-Claisen rearrangement and a high-pressure intramolecular Diels-Alder cycloaddition reaction of an unactivated 2-pyrone derivative, is reported. The implication of the results to the proposed transtaganolides biosynthesis is discussed.

Details

Authors
  • Rikard Larsson
  • Hans W. Scheeren
  • Rene W. M. Aben
  • Martin H Johansson
  • Olov Sterner
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Chemical Sciences

Keywords

  • Transtaganolides, Rearrangement, Cycloaddition, Biosynthesis, Natural, products
Original languageEnglish
Pages (from-to)6955-6960
JournalEuropean Journal of Organic Chemistry
Volume2013
Issue number30
Publication statusPublished - 2013
Publication categoryResearch
Peer-reviewedYes