Towards clinical application of tau PET tracers for diagnosing dementia due to Alzheimer's disease

Research output: Contribution to journalArticle

Abstract

The recent development of several tau positron emission tomography (PET) tracers represents a major milestone for the Alzheimer's disease (AD) field. These tau PET tracers bind tau neurofibrillary tangles, a key neuropathological characteristic of AD that is tightly linked to synaptic loss, brain atrophy, and cognitive decline. It is notable that these tau PET tracers show low uptake in most non-AD tauopathies and other neurodegenerative disorders, resulting in a diagnostic specificity that is superior to that of amyloid beta (Aβ) PET and biofluid markers, especially at an older age when incidental Aβ pathology is common. Furthermore, tau PET tracers diagnostically outperform widely used MRI markers. Given its excellent diagnostic performance due to the combination of high sensitivity and specificity for detecting tau pathology in AD dementia, we hypothesize that tau PET can become an important diagnostic tool in specialized clinics for the differential diagnosis of dementia syndromes where AD is among the major possible underlying diseases.

Details

Authors
Organisations
External organisations
  • Vrije Universiteit Amsterdam
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology

Keywords

  • Alzheimer's disease, CSF, dementia, differential diagnosis, MRI, pathology, PET, plasma, tau, tauopathy
Original languageEnglish
JournalAlzheimer's and Dementia
Publication statusE-pub ahead of print - 2021 May 13
Publication categoryResearch
Peer-reviewedYes