Towards clinical grating-interferometry mammography

Research output: Contribution to journalArticle

Abstract

Objectives: Grating-interferometry-based mammography (GIM) might facilitate breast cancer detection, as several research works have demonstrated in a pre-clinical setting, since it is able to provide attenuation, differential phase contrast, and scattering images simultaneously. In order to translate this technique to the clinics, it has to be adapted to cover a large field-of-view within a clinically acceptable exposure time and radiation dose. Methods: We set up a grating interferometer that fits into a standard mammography system and fulfilled the aforementioned conditions. Here, we present the first mastectomy images acquired with this experimental device. Results and conclusion: Our system performs at a mean glandular dose of 1.6 mGy for a 5-cm-thick, 18%-dense breast, and a field-of-view of 26 × 21 cm2. It seems to be well-suited as basis for a clinical-environment device. Further, dark-field signals seem to support an improved lesion visualization. Evidently, the effective impact of such indications must be evaluated and quantified within the context of a proper reader study. Key Points: • Grating-interferometry-based mammography (GIM) might facilitate breast cancer detection, since it is sensitive to refraction and scattering and thus provides additional tissue information. • The most straightforward way to do grating-interferometry in the clinics is to modify a standard mammography device. • In a first approximation, the doses given with this technique seem to be similar to those of conventional mammography.

Details

Authors
  • Carolina Arboleda
  • Zhentian Wang
  • Konstantins Jefimovs
  • Thomas Koehler
  • Udo Van Stevendaal
  • Norbert Kuhn
  • Bernd David
  • Sven Prevrhal
  • Kristina Lång
  • Serafino Forte
  • Rahel Antonia Kubik-Huch
  • Cornelia Leo
  • Gad Singer
  • Magda Marcon
  • Andreas Boss
  • Ewald Roessl
  • Marco Stampanoni
External organisations
  • ETH Zürich
  • Paul Scherrer Institute
  • Hospital Baden
  • University Hospital of Zurich
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Radiology, Nuclear Medicine and Medical Imaging

Keywords

  • Interferometry, Mammography, Phase contrast
Original languageEnglish
Pages (from-to)1-7
JournalEuropean Radiology
Publication statusPublished - 2019 Aug 22
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes