TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia

Research output: Contribution to journalArticle

Abstract

TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3-6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease progression. (C) 2010 Elsevier Ltd. All rights reserved.

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Authors
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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology

Keywords

  • TP53 mutation, 17p-deletion, Prognosis, Chronic lymphocytic leukemia
Original languageEnglish
Pages (from-to)272-274
JournalLeukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
Volume35
Issue number2
Publication statusPublished - 2011
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematology/Transplantation (013022014)

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