Tracking Parkinson's: Study Design and Baseline Patient Data

Research output: Contribution to journalArticle

Abstract

BACKGROUND: There is wide variation in the phenotypic expression of Parkinson's disease (PD), which is driven by both genetic and epidemiological influences.

OBJECTIVES: To define and explain variation in the clinical phenotype of PD, in relation to genotypic variation.

METHODS: Tracking Parkinson's is a multicentre prospective longitudinal epidemiologic and biomarker study of PD. Patients attending specialist clinics in the United Kingdom with recent onset (<3.5 years) and young onset (diagnosed <50 years of age) PD were enrolled. Motor, non-motor and quality of life assessments were performed using validated scales. Cases are followed up 6 monthly up to 4.5 years for recent onset PD, and up to 1 year for young onset PD. We present here baseline clinical data from this large and demographically representative cohort.

RESULTS: 2247 PD cases were recruited (1987 recent onset, 260 young onset). Recent onset cases had a mean (standard deviation, SD) age of 67.6 years (9.3) at study entry, 65.7% males, with disease duration 1.3 years (0.9), MDS-UPDRS 3 scores 22.9 (12.3), LEDD 295 mg/day (211) and PDQ-8 score 5.9 (4.8). Young onset cases were 53.5 years old (7.8) at study entry, 66.9% male, with disease duration 10.2 years (6.7), MDS-UPDRS 3 scores 27.4 (15.3), LEDD 926 mg/day (567) and PDQ-8 score 11.6 (6.1).

CONCLUSIONS: We have established a large clinical PD cohort, consisting of young onset and recent onset cases, which is designed to evaluate variation in clinical expression, in relation to genetic influences, and which offers a platform for future imaging and biomarker research.

Details

Authors
  • Naveed Malek
  • Diane M A Swallow
  • Katherine A Grosset
  • Michael A Lawton
  • Sarah L Marrinan
  • Alexander C Lehn
  • Catherine Bresner
  • Nin Bajaj
  • Roger A Barker
  • Yoav Ben-Shlomo
  • David J Burn
  • Thomas Foltynie
  • John Hardy
  • Huw R Morris
  • Nigel M Williams
  • Nicholas Wood
  • Donald G Grosset
  • PRoBaND
Organisations
External organisations
  • University of Cambridge
Research areas and keywords

Keywords

  • Adult, Age of Onset, Aged, Female, Follow-Up Studies, Genotype, Humans, Male, Middle Aged, Parkinson Disease, Phenotype, Research Design, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't
Original languageEnglish
Pages (from-to)947-59
Number of pages13
JournalJournal of Parkinson's Disease
Volume5
Issue number4
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes