Transient mechanical benefits of a deep inflation in the injured mouse lung

Research output: Contribution to journalArticle

Abstract

The lasting effects of a recruitment maneuver (RM) in the injured lung are not well characterized. We speculated that the reduction in respiratory elastance (H) after a deep inflation (DI) is transient in nature and should be sustained longer at higher positive end-expiratory pressure (PEEP). Thirteen ventilated mice were given 2 DIs at various levels of PEEP before and after saline lavage. Forced oscillations were used to measure H periodically over 7 min after the DIs. Time constants (tau) were estimated for the post-DI recovery in H. Values for tau before lavage (80-115 s) were reduced after lavage (13-30 s) at all levels of PEEP (P = 0.0001). PEEP did not significantly influence tau before or after lavage. The plateau level and total recovery in H after a DI were significantly influenced by PEEP and lavage (P < 0.0001). Our results suggest that for a DI to be beneficial in the injured mouse lung, it may have to be applied several times a minute.

Details

Authors
  • G Allen
  • Lennart Lundblad
  • P Parsons
  • JHT Bates
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Physiology

Keywords

  • atelectasis, recruitment, positive-pressure respiration, elastance, acute lung injury
Original languageEnglish
Pages (from-to)1709-1715
JournalJournal of Applied Physiology
Volume93
Issue number5
Publication statusPublished - 2002
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Clinical Physiology (013242300), Clinical Physiology and Nuclear Medicine Unit (013242320)