Treating Parkinson's disease in the 21st century: can stem cell transplantation compete?

Research output: Contribution to journalArticle

Abstract

The characteristic and selective degeneration of a unique population of cells-the nigrostriatal dopamine (DA) neurons-that occurs in Parkinson's disease (PD) has made the condition an iconic target for cell replacement therapies. Indeed, transplantation of fetal ventral mesencephalic cells into the DA-deficient striatum was first trialled nearly 30 years ago, at a time when other treatments for the disease were less well developed. Over recent decades standard treatments for PD have advanced, and newer biological therapies are now emerging. In the 21st century, stem cell technology will have to compete alongside other sophisticated treatments, including deep brain stimulation and gene therapies. In this review we examine how stem cell-based transplantation therapies compare with these novel and emerging treatments in the management of this common condition. J. Comp. Neurol. 522:2802-2816, 2014. © 2014 Wiley Periodicals, Inc.

Details

Authors
  • Philip C Buttery
  • Roger A Barker
Organisations
External organisations
  • University of Cambridge
Research areas and keywords

Keywords

  • History, 21st Century, Humans, Parkinson Disease, Stem Cell Transplantation, Historical Article, Journal Article, Research Support, Non-U.S. Gov't, Review
Original languageEnglish
Pages (from-to)2802-16
Number of pages15
JournalJournal of Comparative Neurology
Volume522
Issue number12
Publication statusPublished - 2014 Aug 15
Publication categoryResearch
Peer-reviewedYes