Trichilianones A-D, Novel Cyclopropane-Type Limonoids from Trichilia adolfi

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title = "Trichilianones A-D, Novel Cyclopropane-Type Limonoids from Trichilia adolfi",
abstract = "The fractionation of an ethanol extract of the bark of Trichilia adolfi yielded four novel limonoids (trichilinones A-D, 1-4), with five fused rings and related to the hortiolide-type limonoids. Starting with an ε-lactone, which is α,β-unsaturated in trichilinones A and D (1 and 4), attached to a tetrahydrofuran ring that is connected to an unusual bicyclo [5.1.0] hexane system, joined with a cyclopentanone with a 3-furanyl substituent [(2-oxo)-furan-(5H)-3-yl in trichilinone D (4)], the four compounds isolated display a new 7/5/3/5/5 limonoid ring system. Their structures were established based on extensive analysis of NMR spectroscopic data. As the crude extract possessed anti-leishmanial properties, the compounds were assayed for cytotoxic and anti-parasitic activities in vitro in murine macrophages cells (Raw 264.7) and leishmania promastigotes (L. amazoniensis and L. braziliensis), respectively. The compounds showed moderate cytotoxicity (approximately 70 μg/mL), but are not responsible for the leishmanicidal effect of the extract.",
keywords = "cyclopropane-limonoids, cytotoxicity, leishmanicidal activity, Trichilia adolfi",
author = "Ivan Limachi and Mariela Gonzalez-Ramirez and Sophie Manner and Ticona, {Juan C.} and Efrain Salamanca and Alberto Gimenez and Olov Sterner",
year = "2021",
doi = "10.3390/molecules26041019",
language = "English",
volume = "26",
journal = "Molecules",
issn = "1420-3049",
publisher = "MDPI AG",
number = "4",