TRIM28 and the control of transposable elements in the brain

Research output: Contribution to journalReview article

Abstract

TRIM28 is an epigenetic co-repressor protein that mediates transcriptional silencing. TRIM28 participates, together with the large family of Kruppel-associated box domain zinc finger proteins (KRAB-ZFP) transcription factors, in the repression of transposable elements (TE). Recent advances indicate that TRIM28-based repression of TEs occurs in the mammalian brain and may provide beneficial effects through the regulation of transcriptional networks. Here, we provide an overview of TRIM28-related functions, highlighting the role of controlling TEs in neural progenitor cells and discuss how this mechanism may have contributed to the evolution of the complex human brain. Finally, we outline future considerations for the field.

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Authors
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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • Epigenetics, KRAB-ZFPs, Neurodevelopment, Transposable elements
Original languageEnglish
Pages (from-to)43-47
Number of pages5
JournalBrain Research
Volume1705
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes