TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells.

Research output: Contribution to journalArticle

Abstract

TRIM28 is a corepressor that mediates transcriptional silencing by establishing local heterochromatin. Here, we show that deletion of TRIM28 in neural progenitor cells (NPCs) results in high-level expression of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. We find that NPCs use TRIM28-mediated histone modifications to dynamically regulate transcription and silencing of ERVs, which is in contrast to other somatic cell types using DNA methylation. We also show that derepression of ERVs influences transcriptional dynamics in NPCs through the activation of nearby genes and the expression of long noncoding RNAs. These findings demonstrate a unique dynamic transcriptional regulation of ERVs in NPCs. Our results warrant future studies on the role of ERVs in the healthy and diseased brain.

Details

Authors
  • Liana Fasching
  • Adamandia Kapopoulou
  • Rohit Sachdeva
  • Rebecca Petri
  • Marie Jönsson
  • Christian Männe
  • Priscilla Turelli
  • Patric Jern
  • Florence Cammas
  • Didier Trono
  • Johan Jakobsson
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell Biology
Original languageEnglish
Pages (from-to)20-28
JournalCell Reports
Volume10
Issue number1
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes

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Related research output

Fasching, L., 2015, Molecular Neurogenetics, Faculty of Medicine, Lund University. 74 p.

Research output: ThesisDoctoral Thesis (compilation)

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