Triolein from Coix lacryma-jobi induces cell cycle arrest through p53/p21 signaling pathway

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Bibtex

@article{8573a1d996724336a18350a05fb95e0e,
title = "Triolein from Coix lacryma-jobi induces cell cycle arrest through p53/p21 signaling pathway",
abstract = "p53, a tumor suppressor protein, has important roles in DNA repair, cell cycle and apoptosis, is a one of the key events in cancer development. Coix lacryma-jobi seed has been used as a food and traditional medicine plant with anti-oxidant, anti-cancer and anti-diabetic effects. In currently research, we identified the most potent p53-increasing compound among 4 compounds (1-4) found in Coix lacryma-jobi and demonstrated its molecular mechanism in MCF-7 cells. Among the four isolated compounds (1-4), triolein most increased p53. Triolein treatment induced p53, p21, p27 and Bax in MCF-7 cells. Moreover, triolein caused S phase arrest through suppression of CDK1, phopho-Rb and E2F1 in dose-dependent manner. We also observed the decreasing of DNA synthesis by triolein. These data suggest that triolein may induced cell cycle restart involve DNA synthesis and apoptosis pathway in MCF-7 cells.",
keywords = "Apoptosis, Coix lacryma-jobi, DNA synthesis, MCF-7 cells, Triolein",
author = "{Hien Tran}, Thi and Ha, {Do Thi} and Truong, {Do Minh} and Duc, {Loi Vu} and Dao, {Trong Tuan} and Binh, {Bui Thi} and Hai, {Nguyen Thanh}",
year = "2016",
doi = "10.13005/bpj/967",
language = "English",
volume = "9",
pages = "519--524",
journal = "Biomedical and Pharmacology Journal",
issn = "0974-6242",
publisher = "Oriental Scientific Publishing Company",
number = "2",

}