Trisomy 19 as the sole chromosomal abnormality in proliferative chronic myelomonocytic leukemia

Research output: Contribution to journalArticle

Abstract

Distinct morphologic and clinical features associated with specific chromosomal abnormalities have been described in subgroups of myelodysplastic syndromes (MDS), which often are losses or gains and only rarely translocations. Among 103 consecutive MDS patients diagnosed and karyotyped at the Albert-Ludwigs University of Freiburg (ALU) between 1993 and 1999, two chronic myelomonocytic leukemias (CMMoL) displayed trisomy 19 (+19) as the sole chromosomal abnormality. Three further CMMoL cases with +19 as the single abnormality, two of which previously reported, were collected from other centers. Four of the five patients presented with leukocytosis and splenomegaly, and an increased number of ringed sideroblasts was observed in two cases. Treatment was low-dose Decitabine (cases 1 and 2), oral steroids (case 3), hydroxyurea (case 4), and daunorubicin/Ara-C (case 5). Transformation to acute myeloid leukemias (AML) occurred in three/five patients (cases 1, 2, and 4) 26, 12, and 22 months after diagnosis of CMMoL, respectively. We conclude that +19 as the sole anomaly is a rare but recurrent change in CMMoL, in particular of the proliferative type. It is at present unclear which gene(s) located on chromosome 19 might have a functional role for the development of this phenotype. (c) 2006 Elsevier Ltd. All rights reserved.

Details

Authors
  • M. Daskalakis
  • Nils Mauritzson
  • Bertil Johansson
  • K. Bouabdallah
  • F. Onida
  • R. Kunzmann
  • H. Mueller-Berndorff
  • A. Schmitt-Graeff
  • M. Luebbert
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology

Keywords

  • Decitabine, karyotype, sideroblasts, myelodysplastic/myeloproliferative overlap syndrome, ringed
Original languageEnglish
Pages (from-to)1043-1047
JournalLeukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
Volume30
Issue number8
Publication statusPublished - 2006
Publication categoryResearch
Peer-reviewedYes