Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes.

Research output: Contribution to journalReview article


Trisomy 8 as the sole abnormality is the most common karyotypic finding in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), occurring in approximately 5% and 10% of the cytogenetically abnormal cases, respectively. However, despite the high frequency of +8, much remains to be elucidated as regards its epidemiology, etiology, clinical impact, association with other chromosomal abnormalities, cell of origin, and functional and pathogenetic consequences. Here, we summarize and review these various aspects of trisomy 8, focusing on AMLs and MDS harboring this abnormality as a single change.


Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Genetics


  • sole, trisomy 8, acute myeloid leukemia, chromosomal aberration, myelodysplastic syndrome
Original languageEnglish
Pages (from-to)37-48
JournalPathologie Biologie
Issue number1
Publication statusPublished - 2007
Publication categoryResearch

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