Trisomy 8 in pediatric acute myeloid leukemia: A NOPHO-AML study

Research output: Contribution to journalArticle

Abstract

Trisomy 8 (+8) is a common cytogenetic aberration in acute myeloid leukemia (AML); however, the impact of +8 in pediatric AML is largely unknown. We retrospectively investigated 609 patients from the NOPHO-AML database to determine the clinical and cytogenetic characteristics of +8 in pediatric AML and to investigate its prognostic impact. Complete cytogenetic data were available in 596 patients (98%) aged 0–18 years, diagnosed from 1993 to 2012, and treated according to the NOPHO-AML 1993 and 2004 protocols in the Nordic countries and Hong Kong. We identified 86 patients (14%) with +8. Trisomy 8 was combined with other cytogenetic aberrations in 68 patients (11%) (+8 other) and in 18 patients (3%), it was the sole abnormality (+8 alone). Trisomy 8 was associated with FAB M5 (36%) but otherwise clinically comparable with non-trisomy 8 patients. Trisomy 8 was favorable in patients of young age and with t(9;11). Trisomy 8 alone was associated with older age (median age 10.1 years), FAB M2 (33%), and FLT3-ITD mutations (58%). The 5-year event-free survival for patients with +8 alone was 50% and 5-year overall survival was 75%. In conclusion, +8 is one of the most common cytogenetic aberrations in pediatric AML. Trisomy 8 positive AML is a heterogeneous group and the majority of cases have additional cytogenetic aberrations. Patients with +8 alone differed from patients with +8 other and were associated with older age, FAB M2, and FLT3-ITD aberrations. There were no differences in survival despite the more frequent occurrence of FLT3-ITD in +8 alone.

Details

Authors
  • Anne Cathrine Lund Laursen
  • Julie Damgaard Sandahl
  • Eigil Kjeldsen
  • Jonas Abrahamsson
  • Peter Asdahl
  • Shau Yin Ha
  • Jesper Heldrup
  • Kirsi Jahnukainen
  • Ólafur G. Jónsson
  • Birgitte Lausen
  • Josefine Palle
  • Bernward Zeller
  • Erik Forestier
  • Henrik Hasle
External organisations
  • Aarhus University Hospital
  • Queen Silvia Children’s Hospital
  • Skåne University Hospital
  • University of Helsinki
  • University of Copenhagen
  • Uppsala University
  • Oslo university hospital
  • Norrland University Hospital
  • Queen Mary Hospital
  • National University Hospital of Iceland
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Genetics
  • Cancer and Oncology
Original languageEnglish
Pages (from-to)719-726
Number of pages8
JournalGenes Chromosomes and Cancer
Volume55
Issue number9
Publication statusPublished - 2016 Sep 1
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes