Trophic factors for Parkinson's disease: Where are we and where do we go from here?

Research output: Contribution to journalArticle

Abstract

Perhaps the most important unmet clinical need in Parkinson's disease (PD) is the development of a therapy that can slow or halt disease progression. Extensive preclinical research has provided evidence for the neurorestorative properties of several growth factors, yet only a few have been evaluated in clinical studies. Attempts to achieve neuroprotection by addressing cell-autonomous mechanisms and targeting dopaminergic neurons have been disappointing. Four different trophic factors have so far entered clinical trials in PD: glial cell line-derived growth factor, its close structural and functional analog neurturin, platelet-derived growth factor and cerebral dopaminergic neurotrophic factor. This article reviews the pre-clinical evidence for the neuroprotective and neurorestorative actions of these growth factors and discusses limitations of preclinical models, which may hamper successful translation to the clinic. We summarize the previous and ongoing clinical trials using growth factors in PD and emphasize the caveats in clinical trial design that may prevent the further development and registration of potentially neuroprotective and neurorestorative treatments for individuals suffering from PD.

Details

Authors
Organisations
External organisations
  • Skåne University Hospital
  • University College Cork
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • animal models, CDNF, clinical trials, GDNF, neurotrophic factors, neurturin, Parkinson's disease, PDGF-BB
Original languageEnglish
Pages (from-to)440-452
JournalEuropean Journal of Neuroscience
Volume49
Issue number4
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes