Tumors of endocrine glands

Research output: Chapter in Book/Report/Conference proceedingBook chapter

Abstract

Cytogenetic information is available on roughly 600 neoplasms originating from the thyroid, parathyroid, pituitary, and adrenal glands; from the thymus; and from the endocrine pancreas. Trisomy 7 is found in 30% of adenomas with clonal cytogenetic aberrations. In both the benign and malignant tumors, a combination of gains of or from chromosomes 5, 7, 12, 17, 19, and 20 was observed. Almost all pituitary tumors arise from the adenohypophysis and are benign adenomas; carcinomas are very rare. The clinical heterogeneity of Neuroblastoma (NB) is well reflected by its cytogenetic and genomic features. Clonal chromosome abnormalities were reported in adrenocortical adenomas. Chromosome banding studies have detected cytogenetic aberrations in adrenocortical carcinomas. Clonal chromosome abnormalities have been reported in several thymomas, usually as part of near-diploid karyotypes as well as in a few thymic carcinomas. The use of comparative genomic hybridization (CGH)-based techniques may improve thymoma subtyping.

Details

Authors
Organisations
External organisations
  • University of Bremen
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Genetics

Keywords

  • Adrenal gland, Chromosome banding, Comparative genomic hybridization, Endocrine pancreas, Malignant tumors, Neoplasms, Neuroblastoma, Parathyroid gland, Pituitary gland, Thyroid gland
Original languageEnglish
Title of host publicationCancer Cytogenetics
Subtitle of host publicationChromosomal and Molecular Genetic Aberrations of Tumor Cells
EditorsSverre Heim, Felix Mitelman
PublisherWiley-Blackwell
Pages497-514
Number of pages18
Edition4th
ISBN (Electronic)9781118795569
ISBN (Print)9781118795538
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes