Tumors with non-functional RB1 are killed by reduced gamma-tubulin levels.

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Tumors with non-functional RB1 are killed by reduced gamma-tubulin levels. / Ehlén, Åsa; Rossello Castillo, Catalina Ana; von Stedingk, Kristoffer; Eklund, Greta; Nilsson, Elise; Pettersson, Helen; Jirström, Karin; Alvarado-Kristensson, Maria.

In: Journal of Biological Chemistry, Vol. 287, No. 21, 2012, p. 17241-17247.

Research output: Contribution to journalArticle

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Ehlén, Åsa ; Rossello Castillo, Catalina Ana ; von Stedingk, Kristoffer ; Eklund, Greta ; Nilsson, Elise ; Pettersson, Helen ; Jirström, Karin ; Alvarado-Kristensson, Maria. / Tumors with non-functional RB1 are killed by reduced gamma-tubulin levels. In: Journal of Biological Chemistry. 2012 ; Vol. 287, No. 21. pp. 17241-17247.

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TY - JOUR

T1 - Tumors with non-functional RB1 are killed by reduced gamma-tubulin levels.

AU - Ehlén, Åsa

AU - Rossello Castillo, Catalina Ana

AU - von Stedingk, Kristoffer

AU - Eklund, Greta

AU - Nilsson, Elise

AU - Pettersson, Helen

AU - Jirström, Karin

AU - Alvarado-Kristensson, Maria

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology (Malmö) (013031000), Pathology, (Lund) (013030000), Molecular Medicine (013031200), Molecular Tumour Biology (013017540)

PY - 2012

Y1 - 2012

N2 - In various tumors inactivation of growth control is achieved by interfering with the RB1 signaling pathway. Here, we describe that RB1 and γ tubulin proteins moderate each other's expression by binding to their respective gene promoters. Simultaneous reduction of RB1 and γ tubulin protein levels result in an E2F1-dependent upregulation of apoptotic genes such as caspase 3. We report that in various tumors types, there is an inverse correlation between the expression levels of γ tubulin and RB1 and that in tumor cell lines with a non-functioning RB1, reduction of γ tubulin protein levels leads to induction of apoptosis. Thus, the RB1/γ tubulin signal network can be considered as a new target for cancer treatment.

AB - In various tumors inactivation of growth control is achieved by interfering with the RB1 signaling pathway. Here, we describe that RB1 and γ tubulin proteins moderate each other's expression by binding to their respective gene promoters. Simultaneous reduction of RB1 and γ tubulin protein levels result in an E2F1-dependent upregulation of apoptotic genes such as caspase 3. We report that in various tumors types, there is an inverse correlation between the expression levels of γ tubulin and RB1 and that in tumor cell lines with a non-functioning RB1, reduction of γ tubulin protein levels leads to induction of apoptosis. Thus, the RB1/γ tubulin signal network can be considered as a new target for cancer treatment.

U2 - 10.1074/jbc.M112.357038

DO - 10.1074/jbc.M112.357038

M3 - Article

C2 - 22493456

VL - 287

SP - 17241

EP - 17247

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 1083-351X

IS - 21

ER -