Tuning the protein phosphorylation by receptor type protein tyrosine phosphatase epsilon (PTPRE) in normal and cancer cells

Research output: Contribution to journalArticle

Abstract

Tyrosine phosphorylation is an important post-translation modification of proteins that is controlled by tyrosine kinases and phosphatases. Disruption of the balance between the activity of tyrosine kinases and phosphatases may result in diseases. Receptor type protein tyrosine phosphatase epsilon (PTPRE) is closely related with receptor type protein tyrosine phosphatase alpha (PTPRA). PTPRE has been studied in osteoclast cells, nerve cells, hematopoietic cells, cancer cells and others, and it has different functions among various tissues. In this review, we summarized the current knowledge about the regulation of PTPRE on cellular signal transduction and its function under normal and pathological conditions.

Details

Authors
Organisations
External organisations
  • Ningxia Medical University
  • Chinese University of Hong Kong
  • General Hospital of Ningxia Medical University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology

Keywords

  • Cancer, PTPRE, Signaling, Tyrosine phosphatase
Original languageEnglish
Pages (from-to)105-111
Number of pages7
JournalJournal of Cancer
Volume10
Issue number1
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes