Two genome-wide linkage disequilibrium screens in Scandinavian multiple sclerosis patients

Research output: Contribution to journalArticle

Abstract

We report the first two genome-wide screens for linkage disequilibrium between putative multiple sclerosis (MS) susceptibility genes and genetic markers performed in the genetically homogenous Scandinavian population, using 6000 microsatellite markers and DNA pools of approximately 200 MS cases and 200 controls in each screen. Usable data were achieved from the same 3331 markers in both screens. Nine markers from eight genomic regions (1p33, 3q13, 6p21, 6q14, 7p22, 9p21, 9q21 and Xq22) were identified as potentially associated with MS in both screens. (C) 2003 Elsevier B.V. All rights reserved.

Details

Authors
  • HF Harbo
  • P Datta
  • A Oturai
  • LP Ryder
  • S Sawcer
  • E Setakis
  • E Akesson
  • EG Celius
  • H Modin
  • Magnhild Sandberg Wollheim
  • KM Myhr
  • O Andersen
  • J Hillert
  • PS Sorensen
  • A Svejgaard
  • A Compston
  • F Vartdal
  • A Spurkland
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology

Keywords

  • Scandinavia, multiple sclerosis, genome screen, linkage disequilibrium, DNA pooling
Original languageEnglish
Pages (from-to)101-106
JournalJournal of Neuroimmunology
Volume143
Issue number1-2
Publication statusPublished - 2003
Publication categoryResearch
Peer-reviewedYes