Update of EULAR recommendations for the treatment of systemic sclerosis

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Update of EULAR recommendations for the treatment of systemic sclerosis. / Kowal-Bielecka, Otylia; Fransen, Jaap; Avouac, Jerome; Becker, Mike; Kulak, Agnieszka; Allanore, Yannick; Distler, Oliver; Clements, Philip; Cutolo, Maurizio; Czirjak, Laszlo; Damjanov, Nemanja; del Galdo, Francesco; Denton, Christopher P.; Distler, Jörg H W; Foeldvari, Ivan; Figelstone, Kim; Frerix, Marc; Furst, Daniel E.; Guiducci, Serena; Hunzelmann, Nicolas; Khanna, Dinesh; Matucci-Cerinic, Marco; Herrick, Ariane L.; van den Hoogen, Frank; van Laar, Jacob M.; Riemekasten, Gabriela; Silver, Richard; Smith, Vanessa; Sulli, Alberto; Tarner, Ingo; Tyndall, Alan; Welling, Joep; Wigley, Frederic; Valentini, Gabriele; Walker, Ulrich A.; Zulian, Francesco; Müller-Ladner, Ulf; Daikeler, Thomas; Lanciano, Elisabetta; Becvár, Radim; Tomcik, Michal; Gindzienska-Sieskiewicz, Ewa; Iudici, Michele; Rednic, Simona; Vlachoyiannopoulos, Panayiotis G.; Caporali, Roberto; Carreira, Patricia E.; Novak, Srdan; Minier, Tünde; Kucharz, Eugene J.; Gabrielli, Armando; Moroncini, Gianluca; Airo, Paolo; Hesselstrand, Roger; Martinovic, Duska; Radic, Mislav; Marasovic-Krstulovic, Daniela; Braun-Moscovici, Yolanda; Monaco, Andrea Lo; Morovic-Vergles, Jadranka; Culo, Melanie I.; Henes, Jörg; Santamaria, Vera Ortiz; Heitmann, Stefan; Krasowska, Dorota; Michalska-Jakubus, Malgorzata; Seidel, Matthias F.; Klinik, Medizinische; Hasler, Paul; Da Silva, José A Pereira; Salvador, Maria J.; Stamenkovic, Bojana; Stankovic, Aleksandra; Tikly, Mohammed; Ananieva, Lidia P.; Beretta, Lorenzo; Szucs, Gabriella; Szamosi, Szilvia; de la Puente Bujidos, Carlos; Midtvedt, Øyvind; Hoffmann-Vold, Anna Maria; Launay, David; Hachulla, Eric; Riccieri, Valeria; Ionescu, Ruxandra; Opris, Daniela; Mihai, Carina; Herrgott, Ilka; Beyer, Christian; Ingegnoli, Francesca; von Mühlen, Carlos Alberto; Alegre-Sancho, Juan José; Beltran-Catalan, Emma; Aringer, Martin; Fantana, Julia; Leuchten, Nicolai; Tausche, Anne Kathrin; Langhe, Ellen De; Vanthuyne, Marie; Anic, Branimir; Barešic, Marko; Mayer, Miroslav; üprus, Maria; Otsa, Kati; Yavuz, Sule; Granel, Brigitte; Jimenez, Sergio A.; Popa, Serghei; Agachi, Svetlana; Zenone, Thierry; Stebbings, Simon; Dockerty, Joanne; Vacca, Alessandra; Schollum, Joanna; Veale, Douglas J.; Toloza, Sergio; Xu, Dong; Olas, Jacek; Rosato, Edoardo; Foti, Rosario; Adler, Sabine; Dan, Diana; Wiesik-Szewczyk, Ewa; Olesinska, Marzena; Kayser, Cristiane; Fathi, Nihal; de la Peña Lefebvre, Paloma García; Imbert, Bernard.

In: Annals of the Rheumatic Diseases, Vol. 76, 2017, p. 1327-1339.

Research output: Contribution to journalArticle

Harvard

Kowal-Bielecka, O, Fransen, J, Avouac, J, Becker, M, Kulak, A, Allanore, Y, Distler, O, Clements, P, Cutolo, M, Czirjak, L, Damjanov, N, del Galdo, F, Denton, CP, Distler, JHW, Foeldvari, I, Figelstone, K, Frerix, M, Furst, DE, Guiducci, S, Hunzelmann, N, Khanna, D, Matucci-Cerinic, M, Herrick, AL, van den Hoogen, F, van Laar, JM, Riemekasten, G, Silver, R, Smith, V, Sulli, A, Tarner, I, Tyndall, A, Welling, J, Wigley, F, Valentini, G, Walker, UA, Zulian, F, Müller-Ladner, U, Daikeler, T, Lanciano, E, Becvár, R, Tomcik, M, Gindzienska-Sieskiewicz, E, Iudici, M, Rednic, S, Vlachoyiannopoulos, PG, Caporali, R, Carreira, PE, Novak, S, Minier, T, Kucharz, EJ, Gabrielli, A, Moroncini, G, Airo, P, Hesselstrand, R, Martinovic, D, Radic, M, Marasovic-Krstulovic, D, Braun-Moscovici, Y, Monaco, AL, Morovic-Vergles, J, Culo, MI, Henes, J, Santamaria, VO, Heitmann, S, Krasowska, D, Michalska-Jakubus, M, Seidel, MF, Klinik, M, Hasler, P, Da Silva, JAP, Salvador, MJ, Stamenkovic, B, Stankovic, A, Tikly, M, Ananieva, LP, Beretta, L, Szucs, G, Szamosi, S, de la Puente Bujidos, C, Midtvedt, Ø, Hoffmann-Vold, AM, Launay, D, Hachulla, E, Riccieri, V, Ionescu, R, Opris, D, Mihai, C, Herrgott, I, Beyer, C, Ingegnoli, F, von Mühlen, CA, Alegre-Sancho, JJ, Beltran-Catalan, E, Aringer, M, Fantana, J, Leuchten, N, Tausche, AK, Langhe, ED, Vanthuyne, M, Anic, B, Barešic, M, Mayer, M, üprus, M, Otsa, K, Yavuz, S, Granel, B, Jimenez, SA, Popa, S, Agachi, S, Zenone, T, Stebbings, S, Dockerty, J, Vacca, A, Schollum, J, Veale, DJ, Toloza, S, Xu, D, Olas, J, Rosato, E, Foti, R, Adler, S, Dan, D, Wiesik-Szewczyk, E, Olesinska, M, Kayser, C, Fathi, N, de la Peña Lefebvre, PG & Imbert, B 2017, 'Update of EULAR recommendations for the treatment of systemic sclerosis', Annals of the Rheumatic Diseases, vol. 76, pp. 1327-1339. https://doi.org/10.1136/annrheumdis-2016-209909

APA

Kowal-Bielecka, O., Fransen, J., Avouac, J., Becker, M., Kulak, A., Allanore, Y., Distler, O., Clements, P., Cutolo, M., Czirjak, L., Damjanov, N., del Galdo, F., Denton, C. P., Distler, J. H. W., Foeldvari, I., Figelstone, K., Frerix, M., Furst, D. E., Guiducci, S., ... Imbert, B. (2017). Update of EULAR recommendations for the treatment of systemic sclerosis. Annals of the Rheumatic Diseases, 76, 1327-1339. https://doi.org/10.1136/annrheumdis-2016-209909

CBE

Kowal-Bielecka O, Fransen J, Avouac J, Becker M, Kulak A, Allanore Y, Distler O, Clements P, Cutolo M, Czirjak L, Damjanov N, del Galdo F, Denton CP, Distler JHW, Foeldvari I, Figelstone K, Frerix M, Furst DE, Guiducci S, Hunzelmann N, Khanna D, Matucci-Cerinic M, Herrick AL, van den Hoogen F, van Laar JM, Riemekasten G, Silver R, Smith V, Sulli A, Tarner I, Tyndall A, Welling J, Wigley F, Valentini G, Walker UA, Zulian F, Müller-Ladner U, Daikeler T, Lanciano E, Becvár R, Tomcik M, Gindzienska-Sieskiewicz E, Iudici M, Rednic S, Vlachoyiannopoulos PG, Caporali R, Carreira PE, Novak S, Minier T, Kucharz EJ, Gabrielli A, Moroncini G, Airo P, Hesselstrand R, Martinovic D, Radic M, Marasovic-Krstulovic D, Braun-Moscovici Y, Monaco AL, Morovic-Vergles J, Culo MI, Henes J, Santamaria VO, Heitmann S, Krasowska D, Michalska-Jakubus M, Seidel MF, Klinik M, Hasler P, Da Silva JAP, Salvador MJ, Stamenkovic B, Stankovic A, Tikly M, Ananieva LP, Beretta L, Szucs G, Szamosi S, de la Puente Bujidos C, Midtvedt Ø, Hoffmann-Vold AM, Launay D, Hachulla E, Riccieri V, Ionescu R, Opris D, Mihai C, Herrgott I, Beyer C, Ingegnoli F, von Mühlen CA, Alegre-Sancho JJ, Beltran-Catalan E, Aringer M, Fantana J, Leuchten N, Tausche AK, Langhe ED, Vanthuyne M, Anic B, Barešic M, Mayer M, üprus M, Otsa K, Yavuz S, Granel B, Jimenez SA, Popa S, Agachi S, Zenone T, Stebbings S, Dockerty J, Vacca A, Schollum J, Veale DJ, Toloza S, Xu D, Olas J, Rosato E, Foti R, Adler S, Dan D, Wiesik-Szewczyk E, Olesinska M, Kayser C, Fathi N, de la Peña Lefebvre PG, Imbert B. 2017. Update of EULAR recommendations for the treatment of systemic sclerosis. Annals of the Rheumatic Diseases. 76:1327-1339. https://doi.org/10.1136/annrheumdis-2016-209909

MLA

Vancouver

Author

Kowal-Bielecka, Otylia ; Fransen, Jaap ; Avouac, Jerome ; Becker, Mike ; Kulak, Agnieszka ; Allanore, Yannick ; Distler, Oliver ; Clements, Philip ; Cutolo, Maurizio ; Czirjak, Laszlo ; Damjanov, Nemanja ; del Galdo, Francesco ; Denton, Christopher P. ; Distler, Jörg H W ; Foeldvari, Ivan ; Figelstone, Kim ; Frerix, Marc ; Furst, Daniel E. ; Guiducci, Serena ; Hunzelmann, Nicolas ; Khanna, Dinesh ; Matucci-Cerinic, Marco ; Herrick, Ariane L. ; van den Hoogen, Frank ; van Laar, Jacob M. ; Riemekasten, Gabriela ; Silver, Richard ; Smith, Vanessa ; Sulli, Alberto ; Tarner, Ingo ; Tyndall, Alan ; Welling, Joep ; Wigley, Frederic ; Valentini, Gabriele ; Walker, Ulrich A. ; Zulian, Francesco ; Müller-Ladner, Ulf ; Daikeler, Thomas ; Lanciano, Elisabetta ; Becvár, Radim ; Tomcik, Michal ; Gindzienska-Sieskiewicz, Ewa ; Iudici, Michele ; Rednic, Simona ; Vlachoyiannopoulos, Panayiotis G. ; Caporali, Roberto ; Carreira, Patricia E. ; Novak, Srdan ; Minier, Tünde ; Kucharz, Eugene J. ; Gabrielli, Armando ; Moroncini, Gianluca ; Airo, Paolo ; Hesselstrand, Roger ; Martinovic, Duska ; Radic, Mislav ; Marasovic-Krstulovic, Daniela ; Braun-Moscovici, Yolanda ; Monaco, Andrea Lo ; Morovic-Vergles, Jadranka ; Culo, Melanie I. ; Henes, Jörg ; Santamaria, Vera Ortiz ; Heitmann, Stefan ; Krasowska, Dorota ; Michalska-Jakubus, Malgorzata ; Seidel, Matthias F. ; Klinik, Medizinische ; Hasler, Paul ; Da Silva, José A Pereira ; Salvador, Maria J. ; Stamenkovic, Bojana ; Stankovic, Aleksandra ; Tikly, Mohammed ; Ananieva, Lidia P. ; Beretta, Lorenzo ; Szucs, Gabriella ; Szamosi, Szilvia ; de la Puente Bujidos, Carlos ; Midtvedt, Øyvind ; Hoffmann-Vold, Anna Maria ; Launay, David ; Hachulla, Eric ; Riccieri, Valeria ; Ionescu, Ruxandra ; Opris, Daniela ; Mihai, Carina ; Herrgott, Ilka ; Beyer, Christian ; Ingegnoli, Francesca ; von Mühlen, Carlos Alberto ; Alegre-Sancho, Juan José ; Beltran-Catalan, Emma ; Aringer, Martin ; Fantana, Julia ; Leuchten, Nicolai ; Tausche, Anne Kathrin ; Langhe, Ellen De ; Vanthuyne, Marie ; Anic, Branimir ; Barešic, Marko ; Mayer, Miroslav ; üprus, Maria ; Otsa, Kati ; Yavuz, Sule ; Granel, Brigitte ; Jimenez, Sergio A. ; Popa, Serghei ; Agachi, Svetlana ; Zenone, Thierry ; Stebbings, Simon ; Dockerty, Joanne ; Vacca, Alessandra ; Schollum, Joanna ; Veale, Douglas J. ; Toloza, Sergio ; Xu, Dong ; Olas, Jacek ; Rosato, Edoardo ; Foti, Rosario ; Adler, Sabine ; Dan, Diana ; Wiesik-Szewczyk, Ewa ; Olesinska, Marzena ; Kayser, Cristiane ; Fathi, Nihal ; de la Peña Lefebvre, Paloma García ; Imbert, Bernard. / Update of EULAR recommendations for the treatment of systemic sclerosis. In: Annals of the Rheumatic Diseases. 2017 ; Vol. 76. pp. 1327-1339.

RIS

TY - JOUR

T1 - Update of EULAR recommendations for the treatment of systemic sclerosis

AU - Kowal-Bielecka, Otylia

AU - Fransen, Jaap

AU - Avouac, Jerome

AU - Becker, Mike

AU - Kulak, Agnieszka

AU - Allanore, Yannick

AU - Distler, Oliver

AU - Clements, Philip

AU - Cutolo, Maurizio

AU - Czirjak, Laszlo

AU - Damjanov, Nemanja

AU - del Galdo, Francesco

AU - Denton, Christopher P.

AU - Distler, Jörg H W

AU - Foeldvari, Ivan

AU - Figelstone, Kim

AU - Frerix, Marc

AU - Furst, Daniel E.

AU - Guiducci, Serena

AU - Hunzelmann, Nicolas

AU - Khanna, Dinesh

AU - Matucci-Cerinic, Marco

AU - Herrick, Ariane L.

AU - van den Hoogen, Frank

AU - van Laar, Jacob M.

AU - Riemekasten, Gabriela

AU - Silver, Richard

AU - Smith, Vanessa

AU - Sulli, Alberto

AU - Tarner, Ingo

AU - Tyndall, Alan

AU - Welling, Joep

AU - Wigley, Frederic

AU - Valentini, Gabriele

AU - Walker, Ulrich A.

AU - Zulian, Francesco

AU - Müller-Ladner, Ulf

AU - Daikeler, Thomas

AU - Lanciano, Elisabetta

AU - Becvár, Radim

AU - Tomcik, Michal

AU - Gindzienska-Sieskiewicz, Ewa

AU - Iudici, Michele

AU - Rednic, Simona

AU - Vlachoyiannopoulos, Panayiotis G.

AU - Caporali, Roberto

AU - Carreira, Patricia E.

AU - Novak, Srdan

AU - Minier, Tünde

AU - Kucharz, Eugene J.

AU - Gabrielli, Armando

AU - Moroncini, Gianluca

AU - Airo, Paolo

AU - Hesselstrand, Roger

AU - Martinovic, Duska

AU - Radic, Mislav

AU - Marasovic-Krstulovic, Daniela

AU - Braun-Moscovici, Yolanda

AU - Monaco, Andrea Lo

AU - Morovic-Vergles, Jadranka

AU - Culo, Melanie I.

AU - Henes, Jörg

AU - Santamaria, Vera Ortiz

AU - Heitmann, Stefan

AU - Krasowska, Dorota

AU - Michalska-Jakubus, Malgorzata

AU - Seidel, Matthias F.

AU - Klinik, Medizinische

AU - Hasler, Paul

AU - Da Silva, José A Pereira

AU - Salvador, Maria J.

AU - Stamenkovic, Bojana

AU - Stankovic, Aleksandra

AU - Tikly, Mohammed

AU - Ananieva, Lidia P.

AU - Beretta, Lorenzo

AU - Szucs, Gabriella

AU - Szamosi, Szilvia

AU - de la Puente Bujidos, Carlos

AU - Midtvedt, Øyvind

AU - Hoffmann-Vold, Anna Maria

AU - Launay, David

AU - Hachulla, Eric

AU - Riccieri, Valeria

AU - Ionescu, Ruxandra

AU - Opris, Daniela

AU - Mihai, Carina

AU - Herrgott, Ilka

AU - Beyer, Christian

AU - Ingegnoli, Francesca

AU - von Mühlen, Carlos Alberto

AU - Alegre-Sancho, Juan José

AU - Beltran-Catalan, Emma

AU - Aringer, Martin

AU - Fantana, Julia

AU - Leuchten, Nicolai

AU - Tausche, Anne Kathrin

AU - Langhe, Ellen De

AU - Vanthuyne, Marie

AU - Anic, Branimir

AU - Barešic, Marko

AU - Mayer, Miroslav

AU - üprus, Maria

AU - Otsa, Kati

AU - Yavuz, Sule

AU - Granel, Brigitte

AU - Jimenez, Sergio A.

AU - Popa, Serghei

AU - Agachi, Svetlana

AU - Zenone, Thierry

AU - Stebbings, Simon

AU - Dockerty, Joanne

AU - Vacca, Alessandra

AU - Schollum, Joanna

AU - Veale, Douglas J.

AU - Toloza, Sergio

AU - Xu, Dong

AU - Olas, Jacek

AU - Rosato, Edoardo

AU - Foti, Rosario

AU - Adler, Sabine

AU - Dan, Diana

AU - Wiesik-Szewczyk, Ewa

AU - Olesinska, Marzena

AU - Kayser, Cristiane

AU - Fathi, Nihal

AU - de la Peña Lefebvre, Paloma García

AU - Imbert, Bernard

PY - 2017

Y1 - 2017

N2 - The aim was to update the 2009 European League against Rheumatism (EULAR) recommendations for the treatment of systemic sclerosis (SSc), with attention to new therapeutic questions. Update of the previous treatment recommendations was performed according to EULAR standard operating procedures. The task force consisted of 32 SSc clinical experts from Europe and the USA, 2 patients nominated by the pan-European patient association for SSc (Federation of European Scleroderma Associations (FESCA)), a clinical epidemiologist and 2 research fellows. All centres from the EULAR Scleroderma Trials and Research group were invited to submit and select clinical questions concerning SSc treatment using a Delphi approach. Accordingly, 46 clinical questions addressing 26 different interventions were selected for systematic literature review. The new recommendations were based on the available evidence and developed in a consensus meeting with clinical experts and patients. The procedure resulted in 16 recommendations being developed (instead of 14 in 2009) that address treatment of several SSc-related organ complications: Raynaud's phenomenon (RP), digital ulcers (DUs), pulmonary arterial hypertension (PAH), skin and lung disease, scleroderma renal crisis and gastrointestinal involvement. Compared with the 2009 recommendations, the 2016 recommendations include phosphodiesterase type 5 (PDE-5) inhibitors for the treatment of SSc-related RP and DUs, riociguat, new aspects for endothelin receptor antagonists, prostacyclin analogues and PDE-5 inhibitors for SSc-related PAH. New recommendations regarding the use of fluoxetine for SSc-related RP and haematopoietic stem cell transplantation for selected patients with rapidly progressive SSc were also added. In addition, several comments regarding other treatments addressed in clinical questions and suggestions for the SSc research agenda were formulated. These updated data-derived and consensus-derived recommendations will help rheumatologists to manage patients with SSc in an evidence-based way. These recommendations also give directions for future clinical research in SSc.

AB - The aim was to update the 2009 European League against Rheumatism (EULAR) recommendations for the treatment of systemic sclerosis (SSc), with attention to new therapeutic questions. Update of the previous treatment recommendations was performed according to EULAR standard operating procedures. The task force consisted of 32 SSc clinical experts from Europe and the USA, 2 patients nominated by the pan-European patient association for SSc (Federation of European Scleroderma Associations (FESCA)), a clinical epidemiologist and 2 research fellows. All centres from the EULAR Scleroderma Trials and Research group were invited to submit and select clinical questions concerning SSc treatment using a Delphi approach. Accordingly, 46 clinical questions addressing 26 different interventions were selected for systematic literature review. The new recommendations were based on the available evidence and developed in a consensus meeting with clinical experts and patients. The procedure resulted in 16 recommendations being developed (instead of 14 in 2009) that address treatment of several SSc-related organ complications: Raynaud's phenomenon (RP), digital ulcers (DUs), pulmonary arterial hypertension (PAH), skin and lung disease, scleroderma renal crisis and gastrointestinal involvement. Compared with the 2009 recommendations, the 2016 recommendations include phosphodiesterase type 5 (PDE-5) inhibitors for the treatment of SSc-related RP and DUs, riociguat, new aspects for endothelin receptor antagonists, prostacyclin analogues and PDE-5 inhibitors for SSc-related PAH. New recommendations regarding the use of fluoxetine for SSc-related RP and haematopoietic stem cell transplantation for selected patients with rapidly progressive SSc were also added. In addition, several comments regarding other treatments addressed in clinical questions and suggestions for the SSc research agenda were formulated. These updated data-derived and consensus-derived recommendations will help rheumatologists to manage patients with SSc in an evidence-based way. These recommendations also give directions for future clinical research in SSc.

UR - http://www.scopus.com/inward/record.url?scp=84995487524&partnerID=8YFLogxK

U2 - 10.1136/annrheumdis-2016-209909

DO - 10.1136/annrheumdis-2016-209909

M3 - Article

C2 - 27941129

AN - SCOPUS:84995487524

VL - 76

SP - 1327

EP - 1339

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 1468-2060

ER -