Update on the molecular pathogenesis and targeted approaches of mantle cell lymphoma: summary of the 12th annual conference of the European Mantle Cell Lymphoma Network

Research output: Contribution to journalReview article

Abstract

Mantle cell lymphoma (MCL) is a distinct subtype of malignant lymphoma which is characterized by the chromosomal translocation t(11;14)(q13;q32) resulting in constitutional overexpression of cyclin D1 and cell cycle dysregulation in almost all cases. Clinically, MCL shows an aggressive clinical course with a continuous relapse pattern and a median survival of only 3-5 years. However, recently a subset of 15% long-term survivors has been identified with a rather indolent clinical course. Targeted strategies include the proteasome inhibitors, immune modulatory drugs (IMiDs), mammalian target of rapamycin (mTOR) inhibitors and especially inhibitors of the B-cell receptor pathway. Our recent annual conference focused on the molecular pathogenesis of the disease and how these underlying molecular alterations may guide the selection and integration of innovative approaches for therapy. This review of the meeting covers in particular the identification of indolent cases, and deals with the role of the B-cell receptor pathway in MCL, as well as the detection of minimal residual disease and implementation of molecular approaches in current clinical trials.

Details

Authors
  • Martin Dreyling
  • Virginia Amador
  • Mary Callanan
  • Mats Jerkeman
  • Steven Le Goui
  • Christiane Pott
  • Simon Rule
  • Francesco Zaja
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology

Keywords

  • Mantle cell lymphoma, chemotherapy, targeted therapy, molecular, pathogenesis, minimal residual disease
Original languageEnglish
Pages (from-to)866-876
JournalLeukemia & Lymphoma
Volume56
Issue number4
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes

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