Urinary excretion of the carboxy terminal domain of type IV collagen is associated with kidney size and function in IDDM

Research output: Contribution to journalArticle

Abstract

We evaluated whether urinary excretion of the carboxy terminal domain (NC1) of Type IV collagen is associated with glomerular filtration rate and kidney size in Type I (insulin-dependent) diabetes mellitus (IDDM). Urinary excretion rate of NC1, glomerular filtration rate (GFR), and kidney size were measured in 16 men with Type I diabetes. Their mean age was 33.3 +/- 6.1 years with a duration of diabetes of 14.9 +/- 3.7 years (mean +/- SD). The urinary excretion rate of NC1 was higher in the diabetic patients than in 18 healthy control subjects. Urinary excretion of NC1 was associated with both kidney size, parenchymal width, and GFR (r = 0.73, p = 0.001; r = 0.63, p = 0.009; r = 0.53, p = 0.04, respectively). The exact relationship between these factors and basement membrane turnover/synthesis remains to be elucidated.

Details

Authors
  • Ole Torffvit
  • Jörgen Wieslander
  • Lillemor Forsberg
  • Esbjörn Hederström
  • Carl-David Agardh
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes
  • Urology and Nephrology
  • Other Clinical Medicine
Original languageEnglish
Pages (from-to)166-169
JournalJournal of Diabetic Complications
Volume4
Issue number4
Publication statusPublished - 1990
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Nephrology (013230024), Medicine (Lund) (013230025), Unit on Vascular Diabetic Complications (013241510)