Uterine artery embolization in a sheep model: biodegradable versus non-degradable microspheres

Research output: Contribution to journalArticle

Standard

Uterine artery embolization in a sheep model : biodegradable versus non-degradable microspheres. / Keussen, Inger; Bengtsson, Johan; Gavier-Widén, Dolores; Karlstam, Erika.

In: Acta Radiologica, Vol. 59, No. 10, 2018, p. 1210-1217.

Research output: Contribution to journalArticle

Harvard

APA

CBE

MLA

Vancouver

Author

Keussen, Inger ; Bengtsson, Johan ; Gavier-Widén, Dolores ; Karlstam, Erika. / Uterine artery embolization in a sheep model : biodegradable versus non-degradable microspheres. In: Acta Radiologica. 2018 ; Vol. 59, No. 10. pp. 1210-1217.

RIS

TY - JOUR

T1 - Uterine artery embolization in a sheep model

T2 - biodegradable versus non-degradable microspheres

AU - Keussen, Inger

AU - Bengtsson, Johan

AU - Gavier-Widén, Dolores

AU - Karlstam, Erika

PY - 2018

Y1 - 2018

N2 - Background: Transarterial embolization with particles is a relatively common treatment method in both malignant and benign disorders. Permanent occlusion of the uterine arteries may sometimes be disadvantageous. Purpose: To compare the local tissue effects, possible side effects, and extent of recanalization following uterine artery embolization, using either degradable or non-degradable microspheres in a sheep model. Material and Methods: In 22 female sheep, the uterine artery (UA) was unilaterally, superselectively embolized, with either degradable starch microspheres-DSM (group A) or calibrated gelatin coated spherical shape tris-acryl microspheres-TGMS (group B). The completion of embolization was confirmed by angiography. The animals were kept in the animal research facilities for 14 days and sacrificed following new angiographic evaluation. Gross and histological examination of the uterus and other organs was performed. Results: The procedure was successful in all animals. At final angiographic evaluation recanalization was found in 82% of the ewes in group A and in 18% in group B. At histopathological examination, tissue impairment was similar in both groups, whereas vascular changes were more pronounced in the TGMS-group. Conclusion: Embolization with DSM was associated with significantly higher degree of recanalization, than after embolization with TGMS.

AB - Background: Transarterial embolization with particles is a relatively common treatment method in both malignant and benign disorders. Permanent occlusion of the uterine arteries may sometimes be disadvantageous. Purpose: To compare the local tissue effects, possible side effects, and extent of recanalization following uterine artery embolization, using either degradable or non-degradable microspheres in a sheep model. Material and Methods: In 22 female sheep, the uterine artery (UA) was unilaterally, superselectively embolized, with either degradable starch microspheres-DSM (group A) or calibrated gelatin coated spherical shape tris-acryl microspheres-TGMS (group B). The completion of embolization was confirmed by angiography. The animals were kept in the animal research facilities for 14 days and sacrificed following new angiographic evaluation. Gross and histological examination of the uterus and other organs was performed. Results: The procedure was successful in all animals. At final angiographic evaluation recanalization was found in 82% of the ewes in group A and in 18% in group B. At histopathological examination, tissue impairment was similar in both groups, whereas vascular changes were more pronounced in the TGMS-group. Conclusion: Embolization with DSM was associated with significantly higher degree of recanalization, than after embolization with TGMS.

KW - experimental study

KW - Microspheres

KW - uterine artery embolization

KW - uterus

U2 - 10.1177/0284185118757575

DO - 10.1177/0284185118757575

M3 - Article

C2 - 29444587

AN - SCOPUS:85044277599

VL - 59

SP - 1210

EP - 1217

JO - Acta Radiologica

JF - Acta Radiologica

SN - 1600-0455

IS - 10

ER -