Validation of a brief Multicultural Cognitive Examination (MCE) for evaluation of dementia

Research output: Contribution to journalArticle

Abstract

Background: The aims of this study were to present the psychometric properties of a newly designed cognitive screening instrument, the Multicultural Cognitive Examination (MCE), and to compare it with the Rowland Universal Dementia Assessment Scale (RUDAS) in a multicultural population. Methods: The study was a Western European cross-sectional multicenter study. The MCE consists of four components evaluating separate cognitive functions and was constructed by adding measures of memory, verbal fluency, and visuospatial function to the RUDAS to create a scale with 0 to 100 points. Results: A total of 66 patients with dementia and 123 cognitively intact participants were included across six memory clinics; 96 had minority ethnic background, and 93 had majority ethnic background. Moderate to large differences were present between patients with dementia and control participants on all MCE components. The MCE significantly improved diagnostic accuracy compared with using the RUDAS alone, with area under the curves of.918,.984, and.991 for the RUDAS, MCE composite, and demographically corrected composite scores, respectively. Diagnostic accuracy of the MCE did not significantly differ between minority and majority ethnic groups. Across MCE subcomponents, patients with Alzheimer's disease (AD) dementia performed significantly poorer on the memory component compared with those with non-AD dementia. Conclusions: The MCE is a brief cross-cultural cognitive screening instrument that expands evaluation of the cognitive functions covered by the RUDAS, does not require any specialized training, and may be useful for classification of mild dementia or dementia subtypes.

Details

Authors
  • T. Rune Nielsen
  • Kurt Segers
  • Valérie Vanderaspoilden
  • Ulrike Beinhoff
  • Lennart Minthon
  • Anna Pissiota
  • Peter Bekkhus-Wetterberg
  • Guro Hanevold Bjørkløf
  • Magda Tsolaki
  • Mara Gkioka
  • Gunhild Waldemar
Organisations
External organisations
  • University of Copenhagen
  • University Hospital Brugmann
  • Charité Universitätsmedizin Berlin
  • Oslo university hospital
  • Vestfold Hospital
  • Aristotle University of Thessaloniki
  • Lund University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology

Keywords

  • Alzheimer's disease, Cognitive assessment, dementia, diagnostic accuracy, ethnic groups, multicultural, RUDAS
Original languageEnglish
JournalInternational Journal of Geriatric Psychiatry
Publication statusE-pub ahead of print - 2019 Mar 22
Publication categoryResearch
Peer-reviewedYes