Validity and Responsiveness of At-Home Touch Screen Assessments in Advanced Parkinson's Disease

Research output: Contribution to journalArticle

Abstract

The aim of this study was to investigate if a telemetry test battery can be used to measure effects of Parkinson's disease (PD) treatment intervention and disease progression in patients with fluctuations. Sixty-five patients diagnosed with advanced PD were recruited in an open longitudinal 36-month study; 35 treated with levodopa-carbidopa intestinal gel (LCIG) and 30 were candidates for switching from oral PD treatment to LCIG. They utilized a test battery, consisting of self-assessments of symptoms and fine motor tests (tapping and spiral drawings), four times per day in their homes during week-long test periods. The repeated measurements were summarized into an overall test score (OTS) to represent the global condition of the patient during a test period. Clinical assessments included ratings on unified PD rating scale (UPDRS) and 39-item PD questionnaire (PDQ-39) scales. In LCIG-naive patients, the mean OTS compared to baseline was significantly improved from the first test period on LCIG treatment until month 24. In LCIG-non naive patients, there were no significant changes in the mean OTS until month 36. The OTS correlated adequately with total UPDRS (rho = 0.59) and total PDQ-39 (0.59). Responsiveness measured as effect size was 0.696 and 0.536 for OTS and UPDRS, respectively. The trends of the test scores were similar to the trends of clinical rating scores but the dropout rate was high. Correlations betweenOTS and clinical rating scales were adequate indicating that the test battery contains important elements of the information of well-established scales. The responsiveness and reproducibility were better for OTS than for total UPDRS.

Details

Authors
  • Mevludin Memedi
  • Dag Nyholm
  • Anders Johansson
  • Sven Palhagen
  • Thomas Willows
  • Håkan Widner
  • Jan Linder
  • Jerker Westin
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology
  • Public Health, Global Health, Social Medicine and Epidemiology

Keywords

  • telemedicine., monitoring, remote, disease (PD), Parkinson's, levodopa infusion, Home assessment
Original languageEnglish
Pages (from-to)1829-1834
JournalIEEE Journal of Biomedical and Health Informatics
Volume19
Issue number6
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes