Variation in human milk composition is related to differences in milk and infant fecal microbial communities

Research output: Contribution to journalArticle

Standard

Variation in human milk composition is related to differences in milk and infant fecal microbial communities. / Pace, Ryan M.; Williams, Janet E.; Robertson, Bianca; Lackey, Kimberly A.; Meehan, Courtney L.; Price, William J.; Foster, James A.; Sellen, Daniel W.; Kamau-Mbuthia, Elizabeth W.; Kamundia, Egidioh W.; Mbugua, Samwel; Moore, Sophie E.; Prentice, Andrew M.; Kita, Debela G.; Kvist, Linda J.; Otoo, Gloria E.; Ruiz, Lorena; Rodríguez, Juan M.; Pareja, Rossina G.; McGuire, Mark A.; Bode, Lars; McGuire, Michelle K.

In: Microorganisms, Vol. 9, No. 6, 1153, 01.06.2021.

Research output: Contribution to journalArticle

Harvard

Pace, RM, Williams, JE, Robertson, B, Lackey, KA, Meehan, CL, Price, WJ, Foster, JA, Sellen, DW, Kamau-Mbuthia, EW, Kamundia, EW, Mbugua, S, Moore, SE, Prentice, AM, Kita, DG, Kvist, LJ, Otoo, GE, Ruiz, L, Rodríguez, JM, Pareja, RG, McGuire, MA, Bode, L & McGuire, MK 2021, 'Variation in human milk composition is related to differences in milk and infant fecal microbial communities', Microorganisms, vol. 9, no. 6, 1153. https://doi.org/10.3390/microorganisms9061153

APA

Pace, R. M., Williams, J. E., Robertson, B., Lackey, K. A., Meehan, C. L., Price, W. J., Foster, J. A., Sellen, D. W., Kamau-Mbuthia, E. W., Kamundia, E. W., Mbugua, S., Moore, S. E., Prentice, A. M., Kita, D. G., Kvist, L. J., Otoo, G. E., Ruiz, L., Rodríguez, J. M., Pareja, R. G., ... McGuire, M. K. (2021). Variation in human milk composition is related to differences in milk and infant fecal microbial communities. Microorganisms, 9(6), [1153]. https://doi.org/10.3390/microorganisms9061153

CBE

Pace RM, Williams JE, Robertson B, Lackey KA, Meehan CL, Price WJ, Foster JA, Sellen DW, Kamau-Mbuthia EW, Kamundia EW, Mbugua S, Moore SE, Prentice AM, Kita DG, Kvist LJ, Otoo GE, Ruiz L, Rodríguez JM, Pareja RG, McGuire MA, Bode L, McGuire MK. 2021. Variation in human milk composition is related to differences in milk and infant fecal microbial communities. Microorganisms. 9(6):Article 1153. https://doi.org/10.3390/microorganisms9061153

MLA

Vancouver

Author

Pace, Ryan M. ; Williams, Janet E. ; Robertson, Bianca ; Lackey, Kimberly A. ; Meehan, Courtney L. ; Price, William J. ; Foster, James A. ; Sellen, Daniel W. ; Kamau-Mbuthia, Elizabeth W. ; Kamundia, Egidioh W. ; Mbugua, Samwel ; Moore, Sophie E. ; Prentice, Andrew M. ; Kita, Debela G. ; Kvist, Linda J. ; Otoo, Gloria E. ; Ruiz, Lorena ; Rodríguez, Juan M. ; Pareja, Rossina G. ; McGuire, Mark A. ; Bode, Lars ; McGuire, Michelle K. / Variation in human milk composition is related to differences in milk and infant fecal microbial communities. In: Microorganisms. 2021 ; Vol. 9, No. 6.

RIS

TY - JOUR

T1 - Variation in human milk composition is related to differences in milk and infant fecal microbial communities

AU - Pace, Ryan M.

AU - Williams, Janet E.

AU - Robertson, Bianca

AU - Lackey, Kimberly A.

AU - Meehan, Courtney L.

AU - Price, William J.

AU - Foster, James A.

AU - Sellen, Daniel W.

AU - Kamau-Mbuthia, Elizabeth W.

AU - Kamundia, Egidioh W.

AU - Mbugua, Samwel

AU - Moore, Sophie E.

AU - Prentice, Andrew M.

AU - Kita, Debela G.

AU - Kvist, Linda J.

AU - Otoo, Gloria E.

AU - Ruiz, Lorena

AU - Rodríguez, Juan M.

AU - Pareja, Rossina G.

AU - McGuire, Mark A.

AU - Bode, Lars

AU - McGuire, Michelle K.

N1 - Funding Information: Funding: This research was funded by the National Science Foundation IOS-BIO 1344288; the Ministry of Economy and Competitiveness, Spain (AGL2013-4190-P); the European Commission (624773-FP-7-PEOPLE-2013-IEF, to LR); and in part by National Institutes of Health NICHD R01-HD092297 and COBRE Phase III grant P30GM103324. Sterile, single-use milk collection kits were provided by Medela Inc.

PY - 2021/6/1

Y1 - 2021/6/1

N2 - Previously published data from our group and others demonstrate that human milk oligosaccharide (HMOs), as well as milk and infant fecal microbial profiles, vary by geography. However, little is known about the geographical variation of other milk-borne factors, such as lactose and protein, as well as the associations among these factors and microbial community structures in milk and infant feces. Here, we characterized and contrasted concentrations of milk-borne lactose, protein, and HMOs, and examined their associations with milk and infant fecal microbiomes in samples collected in 11 geographically diverse sites. Although geographical site was strongly associated with milk and infant fecal microbiomes, both sample types assorted into a smaller number of community state types based on shared microbial profiles. Similar to HMOs, concentrations of lactose and protein also varied by geography. Concentrations of HMOs, lactose, and protein were associated with differences in the microbial community structures of milk and infant feces and in the abundance of specific taxa. Taken together, these data suggest that the composition of human milk, even when produced by relatively healthy women, differs based on geographical boundaries and that concentrations of HMOs, lactose, and protein in milk are related to variation in milk and infant fecal microbial communities.

AB - Previously published data from our group and others demonstrate that human milk oligosaccharide (HMOs), as well as milk and infant fecal microbial profiles, vary by geography. However, little is known about the geographical variation of other milk-borne factors, such as lactose and protein, as well as the associations among these factors and microbial community structures in milk and infant feces. Here, we characterized and contrasted concentrations of milk-borne lactose, protein, and HMOs, and examined their associations with milk and infant fecal microbiomes in samples collected in 11 geographically diverse sites. Although geographical site was strongly associated with milk and infant fecal microbiomes, both sample types assorted into a smaller number of community state types based on shared microbial profiles. Similar to HMOs, concentrations of lactose and protein also varied by geography. Concentrations of HMOs, lactose, and protein were associated with differences in the microbial community structures of milk and infant feces and in the abundance of specific taxa. Taken together, these data suggest that the composition of human milk, even when produced by relatively healthy women, differs based on geographical boundaries and that concentrations of HMOs, lactose, and protein in milk are related to variation in milk and infant fecal microbial communities.

KW - Bacteria

KW - Breastmilk

KW - Gastrointestinal tract

KW - HMO

KW - Human milk

KW - Infant

KW - Lactose

KW - Microbiome

KW - Oligosaccharides

KW - Protein

UR - http://www.scopus.com/inward/record.url?scp=85106585862&partnerID=8YFLogxK

U2 - 10.3390/microorganisms9061153

DO - 10.3390/microorganisms9061153

M3 - Article

C2 - 34072117

AN - SCOPUS:85106585862

VL - 9

JO - Microorganisms

JF - Microorganisms

SN - 2076-2607

IS - 6

M1 - 1153

ER -