Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Vascular endothelial growth factors (VEGFs) and their receptors are essential regulators of vasculogenesis and angiogenesis in both embryos and adults. One of the factors with a still unknown physiological function is VEGF-B, which is expressed in many tissues, including the heart. METHODS AND RESULTS: Mice carrying a targeted deletion in the VEGF-B gene were developed. In VEGF-B(-/-) animals, no gross abnormalities were observed in organs that normally show high expression of VEGF-B, such as the heart, muscle, and kidney. Analysis of heart function by ECG showed that adult VEGF-B(-/-) mice have an atrial conduction abnormality characterized by a prolonged PQ interval. VEGF- or basic fibroblast growth factor-induced corneal angiogenesis was similar in normal and VEGF-B(-/-) mice. CONCLUSIONS: VEGF-B seems to be required for normal heart function in adult animals but is not required for proper development of the cardiovascular system either during development or for angiogenesis in adults.

Details

Authors
  • Karin Aase
  • Gabriel von Euler
  • Xuri Li
  • Annica Pontén
  • Peter Thoren
  • Renhai Cao
  • Yihai Cao
  • Birgitta Olofsson
  • Samuel Gebre-Medhin
  • Milos Pekny
  • Kari Alitalo
  • Christer Betsholtz
  • Ulf Eriksson
External organisations
  • Ludwig Institute for Cancer Research, Uppsala branch
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems

Keywords

  • electrocardiography, growth substances, angiogenesis, atrium, conduction
Original languageEnglish
Pages (from-to)358
JournalCirculation
Volume104
Issue number3
Publication statusPublished - 2001
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematopoietic Stem Cell Laboratory (013022012)