Ventricular kinetic energy in young fontan patients

Research output: Contribution to journalPublished meeting abstract

Abstract

Introduction: Four-dimensional (4D) flow magnetic resonance imaging (MRI) enables kinetic energy (KE) quantification of intraventricular blood flow. In this study we aimed to quantify the KE in in patients with univentricular heart and to assess the change in the KE after different types of interventions. Methods: 4D flow MRI was acquired in patients with Fontan circulation (n=12; median age 12, range 3-29 years) and in healthy volunteers (n =8; median age 26, range 23-36 years). MRI was repeated after transcatheter embolization of significant aortopulmonary collaterals (APC; n = 1), after stenting of left pulmonary artery (n=1) and after surgical replacement of hepatic flow tunnel with a Y graft due to significant central pulmonary artery stenosis with secondary formation of arteriovenous (AV) fistulas in the right lung (n= 1). Intraventricular KE was calculated throughout the cardiac cycle and indexed to stroke volume (SV). Results: The systole/diastole ratio of KE in Fontan patients was similar to the ratio of the controls' left ventricle (LV) or right ventricle (RV) depending on the ventricular morphology (Coheńs kappa =1.0). Peak systolic KE/SV did not differ in patients compared to the LV in controls (0.016 ± 0.006 mJ/ml vs 0.020 ±0.004 mJ/ml, p= 0.09). Peak diastolic KE/SV in Fontan patients was lower than in the LV of the control group (0.028 ±0.010 vs 0.057± 0.011 mJ/ml, p

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pediatrics

Keywords

  • adolescent, adult, arteriovenous fistula, artificial embolization, child, clinical article, control group, controlled study, diastole, follow up, heart contraction, heart cycle, heart left ventricle, heart right ventricle, heart single ventricle, heart stroke volume, human, inhibition kinetics, liver blood flow, morphology, nuclear magnetic resonance imaging, pulmonary artery stenosis, quantitative study, right lung, stent, surgery, volunteer
Original languageEnglish
Pages (from-to)S64
Number of pages1
JournalCardiology in the Young
Volume26
Issue numberSuppl 1
Publication statusPublished - 2016 May 1
Publication categoryResearch
Peer-reviewedYes
Event50th Annual Meeting of the Association for European Paediatric and Congenital Cardiology - , Italy
Duration: 2016 Jun 12016 Jun 4