Vitamin B6 Vitamer concentrations in cerebrospinal fluid differ between preterm and termnewborn infants

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Vitamin B6 Vitamer concentrations in cerebrospinal fluid differ between preterm and termnewborn infants. / Albersen, Monique; Groenendaal, Floris; Van Ham, Maria Der; De Koning, Tom J.; Bosma, Marjolein; Visser, Wouter F.; Visser, Gepke; De Sain-van Der Velden, Monique G.M.; Verhoeven-Duif, Nanda M.

In: Pediatrics, Vol. 130, No. 1, 01.07.2012.

Research output: Contribution to journalArticle

Harvard

Albersen, M, Groenendaal, F, Van Ham, MD, De Koning, TJ, Bosma, M, Visser, WF, Visser, G, De Sain-van Der Velden, MGM & Verhoeven-Duif, NM 2012, 'Vitamin B6 Vitamer concentrations in cerebrospinal fluid differ between preterm and termnewborn infants', Pediatrics, vol. 130, no. 1. https://doi.org/10.1542/peds.2011-3751

APA

Albersen, M., Groenendaal, F., Van Ham, M. D., De Koning, T. J., Bosma, M., Visser, W. F., Visser, G., De Sain-van Der Velden, M. G. M., & Verhoeven-Duif, N. M. (2012). Vitamin B6 Vitamer concentrations in cerebrospinal fluid differ between preterm and termnewborn infants. Pediatrics, 130(1). https://doi.org/10.1542/peds.2011-3751

CBE

Albersen M, Groenendaal F, Van Ham MD, De Koning TJ, Bosma M, Visser WF, Visser G, De Sain-van Der Velden MGM, Verhoeven-Duif NM. 2012. Vitamin B6 Vitamer concentrations in cerebrospinal fluid differ between preterm and termnewborn infants. Pediatrics. 130(1). https://doi.org/10.1542/peds.2011-3751

MLA

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Albersen, Monique ; Groenendaal, Floris ; Van Ham, Maria Der ; De Koning, Tom J. ; Bosma, Marjolein ; Visser, Wouter F. ; Visser, Gepke ; De Sain-van Der Velden, Monique G.M. ; Verhoeven-Duif, Nanda M. / Vitamin B6 Vitamer concentrations in cerebrospinal fluid differ between preterm and termnewborn infants. In: Pediatrics. 2012 ; Vol. 130, No. 1.

RIS

TY - JOUR

T1 - Vitamin B6 Vitamer concentrations in cerebrospinal fluid differ between preterm and termnewborn infants

AU - Albersen, Monique

AU - Groenendaal, Floris

AU - Van Ham, Maria Der

AU - De Koning, Tom J.

AU - Bosma, Marjolein

AU - Visser, Wouter F.

AU - Visser, Gepke

AU - De Sain-van Der Velden, Monique G.M.

AU - Verhoeven-Duif, Nanda M.

PY - 2012/7/1

Y1 - 2012/7/1

N2 - BACKGROUND AND OBJECTIVE: Vitamin B6 plays a pivotal role in brain development and functioning. Differences in vitamin B6 homeostasis between preterm and term newborn infants have been reported. The authors sought to investigate whether B6 vitamers in cerebrospinal fluid (CSF) of preterm and term newborn infants are different. METHODS: B6 vitamer concentrations were determined in 69 CSF samples of 36 newborn infants (26 born preterm and 10 born term) by ultra performance liquid chromatography-tandem mass spectrometry. CSF samples, taken from a subcutaneous intraventricular reservoir, were bedside frozen and protected from light. RESULTS: Concentrations of pyridoxal (PL), pyridoxal phosphate (PLP), pyridoxic acid (PA), and pyridoxamine (PM) in preterm newborns (postmenstrual age 30-37 weeks) were at least twice as high as in older newborns (postmenstrual age ≥42 weeks). Pyridoxine and pyridoxamine phosphate concentrations were below limits of quantification in all newborns. In CSF of 2 very preterm newborns (postmenstrual age <30 weeks), significant amounts of pyridoxine were present besides high concentrations of PL, PA, and PM, whereas PLP concentrations were relatively low. B6 vitamers in CSF were positively correlated, especially PA, PLP, and PL. CONCLUSIONS: In CSF of newborn infants, PL, PLP, PA, and PM are present, and concentrations are strongly dependent on postmenstrual age. Our results indicate that vitamin B6 homeostasis in brain differs between preterm and term newborns. These results should be taken into account for diagnosis and treatment of epilepsy and vitamin B6 deficiency in newborn infants.

AB - BACKGROUND AND OBJECTIVE: Vitamin B6 plays a pivotal role in brain development and functioning. Differences in vitamin B6 homeostasis between preterm and term newborn infants have been reported. The authors sought to investigate whether B6 vitamers in cerebrospinal fluid (CSF) of preterm and term newborn infants are different. METHODS: B6 vitamer concentrations were determined in 69 CSF samples of 36 newborn infants (26 born preterm and 10 born term) by ultra performance liquid chromatography-tandem mass spectrometry. CSF samples, taken from a subcutaneous intraventricular reservoir, were bedside frozen and protected from light. RESULTS: Concentrations of pyridoxal (PL), pyridoxal phosphate (PLP), pyridoxic acid (PA), and pyridoxamine (PM) in preterm newborns (postmenstrual age 30-37 weeks) were at least twice as high as in older newborns (postmenstrual age ≥42 weeks). Pyridoxine and pyridoxamine phosphate concentrations were below limits of quantification in all newborns. In CSF of 2 very preterm newborns (postmenstrual age <30 weeks), significant amounts of pyridoxine were present besides high concentrations of PL, PA, and PM, whereas PLP concentrations were relatively low. B6 vitamers in CSF were positively correlated, especially PA, PLP, and PL. CONCLUSIONS: In CSF of newborn infants, PL, PLP, PA, and PM are present, and concentrations are strongly dependent on postmenstrual age. Our results indicate that vitamin B6 homeostasis in brain differs between preterm and term newborns. These results should be taken into account for diagnosis and treatment of epilepsy and vitamin B6 deficiency in newborn infants.

KW - Cerebrospinal fluid

KW - Newborn infants

KW - Vitamin B

UR - http://www.scopus.com/inward/record.url?scp=84863520422&partnerID=8YFLogxK

U2 - 10.1542/peds.2011-3751

DO - 10.1542/peds.2011-3751

M3 - Article

C2 - 22732169

AN - SCOPUS:84863520422

VL - 130

JO - Pediatrics

JF - Pediatrics

SN - 1098-4275

IS - 1

ER -