Vitamin K and cancer

Research output: Contribution to journalArticle

Abstract

Subclinical vitamin K deficits refer to carboxylation defects of different types of vitamin K-dependent hepatic and extrahepatic so-called Gla proteins without prolongation of the prothrombin time. This condition has been reported in different clinical situations due to insufficient supply or malabsorption of vitamin K as well as drug interactions. This review discusses the effects of different vitamin K subspecies on tumour growth and the possible anti-tumour effects of increased vitamin K intake. Blocking carboxylation of vitamin K-dependent proteins with warfarin anticoagulation – what are the risks/benefits for carcinogenesis? Previous studies on both heparin and low molecular weight heparin blocking of the vitamin K-dependent factors X and II have shown tumour suppressive effects. Vitamin K has anti-inflammatory effects that could also impact carcinogenesis, but little data exists on this subject.

Details

Authors
Organisations
External organisations
  • Skåne University Hospital
  • Lund University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology

Keywords

  • anticoagulants, apoptosis, cell cycle checkpoints, growth arrest-specific protein 6, matrix Gla protein, neoplasm, osteocalcin, PIVKA-II, steroid and xenobiotic receptor, Vitamin K
Original languageEnglish
Pages (from-to)555-567
JournalScandinavian Journal of Clinical and Laboratory Investigation
Volume77
Issue number8
Early online date2017 Sep 21
Publication statusPublished - 2017
Publication categoryResearch
Peer-reviewedYes

Related projects

Ulf Schött

1990/05/012019/03/31

Project: Research

View all (1)