von Willebrand disease update: diagnostic and treatment dilemmas

Research output: Contribution to journalArticle

Abstract

Although von Willebrand disease (VWD) is now well-described, many facets of diagnosis and management continue to be debated. The diagnosis of type 1 disease can be difficult but recent genetic analyses help to distinguish many factors which can influence von Willebrand factor (VWF) levels and bleeding phenotype. Type 2 disease (functional abnormalities) includes a particularly interesting group of disorders with faulty binding between VWF and FVIIIC (Normandy) where treatment methods need careful consideration. Type 3 VWD is the most severe form of VWD and a new international study is underway to examine the use of prophylaxis.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology

Keywords

  • diagnosis, molecular genetics, prophylaxis study, VWD, VWD type 3, VWD Normandy
Original languageEnglish
Pages (from-to)56-61
JournalHaemophilia
Volume14
Issue numbers3
Publication statusPublished - 2008
Publication categoryResearch
Peer-reviewedYes