Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study

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Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study. / Emaus, Marleen J.; van Gils, Carla H.; Bakker, Marije F.; Bisschop, Charlotte N. Steins; Monninkhof, Evelyn M.; Bueno-de-Mesquita, H. B(as); Travier, Noemie; Berentzen, Tina Landsvig; Overvad, Kim; Tjonneland, Anne; Romieu, Isabelle; Rinaldi, Sabina; Chajes, Veronique; Gunter, Marc J.; Clavel-Chapelon, Francoise; Fagherazzi, Guy; Mesrine, Sylvie; Chang-Claude, Jenny; Kaaks, Rudolf; Boeing, Heiner; Aleksandrova, Krasimira; Trichopoulou, Antonia; Naska, Androniki; Orfanos, Philippos; Palli, Domenico; Agnoli, Claudia; Tumino, Rosario; Vineis, Paolo; Mattiello, Amalia; Braaten, Tonje; Borch, Kristin Benjaminsen; Lund, Eiliv; Menendez, Virginia; Sanchez, Maria-Jose; Navarro, Carmen; Barricarte, Aurelio; Amiano, Pilar; Sund, Malin; Andersson, Anne; Borgquist, Signe; Olsson, Åsa; Khaw, Kay-Tee; Wareham, Nick; Travis, Ruth C.; Riboli, Elio; Peeters, Petra H. M.; May, Anne M.

In: International Journal of Cancer, Vol. 135, No. 12, 2014, p. 2887-2899.

Research output: Contribution to journalArticle

Harvard

Emaus, MJ, van Gils, CH, Bakker, MF, Bisschop, CNS, Monninkhof, EM, Bueno-de-Mesquita, HB, Travier, N, Berentzen, TL, Overvad, K, Tjonneland, A, Romieu, I, Rinaldi, S, Chajes, V, Gunter, MJ, Clavel-Chapelon, F, Fagherazzi, G, Mesrine, S, Chang-Claude, J, Kaaks, R, Boeing, H, Aleksandrova, K, Trichopoulou, A, Naska, A, Orfanos, P, Palli, D, Agnoli, C, Tumino, R, Vineis, P, Mattiello, A, Braaten, T, Borch, KB, Lund, E, Menendez, V, Sanchez, M-J, Navarro, C, Barricarte, A, Amiano, P, Sund, M, Andersson, A, Borgquist, S, Olsson, Å, Khaw, K-T, Wareham, N, Travis, RC, Riboli, E, Peeters, PHM & May, AM 2014, 'Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study', International Journal of Cancer, vol. 135, no. 12, pp. 2887-2899. https://doi.org/10.1002/ijc.28926

APA

Emaus, M. J., van Gils, C. H., Bakker, M. F., Bisschop, C. N. S., Monninkhof, E. M., Bueno-de-Mesquita, H. B., Travier, N., Berentzen, T. L., Overvad, K., Tjonneland, A., Romieu, I., Rinaldi, S., Chajes, V., Gunter, M. J., Clavel-Chapelon, F., Fagherazzi, G., Mesrine, S., Chang-Claude, J., Kaaks, R., ... May, A. M. (2014). Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study. International Journal of Cancer, 135(12), 2887-2899. https://doi.org/10.1002/ijc.28926

CBE

Emaus MJ, van Gils CH, Bakker MF, Bisschop CNS, Monninkhof EM, Bueno-de-Mesquita HB, Travier N, Berentzen TL, Overvad K, Tjonneland A, Romieu I, Rinaldi S, Chajes V, Gunter MJ, Clavel-Chapelon F, Fagherazzi G, Mesrine S, Chang-Claude J, Kaaks R, Boeing H, Aleksandrova K, Trichopoulou A, Naska A, Orfanos P, Palli D, Agnoli C, Tumino R, Vineis P, Mattiello A, Braaten T, Borch KB, Lund E, Menendez V, Sanchez M-J, Navarro C, Barricarte A, Amiano P, Sund M, Andersson A, Borgquist S, Olsson Å, Khaw K-T, Wareham N, Travis RC, Riboli E, Peeters PHM, May AM. 2014. Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study. International Journal of Cancer. 135(12):2887-2899. https://doi.org/10.1002/ijc.28926

MLA

Vancouver

Emaus MJ, van Gils CH, Bakker MF, Bisschop CNS, Monninkhof EM, Bueno-de-Mesquita HB et al. Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study. International Journal of Cancer. 2014;135(12):2887-2899. https://doi.org/10.1002/ijc.28926

Author

Emaus, Marleen J. ; van Gils, Carla H. ; Bakker, Marije F. ; Bisschop, Charlotte N. Steins ; Monninkhof, Evelyn M. ; Bueno-de-Mesquita, H. B(as) ; Travier, Noemie ; Berentzen, Tina Landsvig ; Overvad, Kim ; Tjonneland, Anne ; Romieu, Isabelle ; Rinaldi, Sabina ; Chajes, Veronique ; Gunter, Marc J. ; Clavel-Chapelon, Francoise ; Fagherazzi, Guy ; Mesrine, Sylvie ; Chang-Claude, Jenny ; Kaaks, Rudolf ; Boeing, Heiner ; Aleksandrova, Krasimira ; Trichopoulou, Antonia ; Naska, Androniki ; Orfanos, Philippos ; Palli, Domenico ; Agnoli, Claudia ; Tumino, Rosario ; Vineis, Paolo ; Mattiello, Amalia ; Braaten, Tonje ; Borch, Kristin Benjaminsen ; Lund, Eiliv ; Menendez, Virginia ; Sanchez, Maria-Jose ; Navarro, Carmen ; Barricarte, Aurelio ; Amiano, Pilar ; Sund, Malin ; Andersson, Anne ; Borgquist, Signe ; Olsson, Åsa ; Khaw, Kay-Tee ; Wareham, Nick ; Travis, Ruth C. ; Riboli, Elio ; Peeters, Petra H. M. ; May, Anne M. / Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study. In: International Journal of Cancer. 2014 ; Vol. 135, No. 12. pp. 2887-2899.

RIS

TY - JOUR

T1 - Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study

AU - Emaus, Marleen J.

AU - van Gils, Carla H.

AU - Bakker, Marije F.

AU - Bisschop, Charlotte N. Steins

AU - Monninkhof, Evelyn M.

AU - Bueno-de-Mesquita, H. B(as)

AU - Travier, Noemie

AU - Berentzen, Tina Landsvig

AU - Overvad, Kim

AU - Tjonneland, Anne

AU - Romieu, Isabelle

AU - Rinaldi, Sabina

AU - Chajes, Veronique

AU - Gunter, Marc J.

AU - Clavel-Chapelon, Francoise

AU - Fagherazzi, Guy

AU - Mesrine, Sylvie

AU - Chang-Claude, Jenny

AU - Kaaks, Rudolf

AU - Boeing, Heiner

AU - Aleksandrova, Krasimira

AU - Trichopoulou, Antonia

AU - Naska, Androniki

AU - Orfanos, Philippos

AU - Palli, Domenico

AU - Agnoli, Claudia

AU - Tumino, Rosario

AU - Vineis, Paolo

AU - Mattiello, Amalia

AU - Braaten, Tonje

AU - Borch, Kristin Benjaminsen

AU - Lund, Eiliv

AU - Menendez, Virginia

AU - Sanchez, Maria-Jose

AU - Navarro, Carmen

AU - Barricarte, Aurelio

AU - Amiano, Pilar

AU - Sund, Malin

AU - Andersson, Anne

AU - Borgquist, Signe

AU - Olsson, Åsa

AU - Khaw, Kay-Tee

AU - Wareham, Nick

AU - Travis, Ruth C.

AU - Riboli, Elio

AU - Peeters, Petra H. M.

AU - May, Anne M.

PY - 2014

Y1 - 2014

N2 - Long-term weight gain (i.e., weight gain since age 20) has been related to higher risk of postmenopausal breast cancer, but a lower risk of premenopausal breast cancer. The effect of weight change in middle adulthood is unclear. We investigated the association between weight change in middle adulthood (i.e., women aged 40-50 years) and the risk of breast cancer before and after the age of 50. We included female participants of the European Prospective Investigation into Cancer and Nutrition cohort, with information on anthropometric measures at recruitment and after a median follow-up of 4.3 years. Annual weight change was categorized using quintiles taking quintile 2 and 3 as the reference category (-0.44 to 0.36 kg/year). Multivariable Cox proportional hazards regression analysis was used to examine the association. 205,723 women were included and 4,663 incident breast cancer cases were diagnosed during a median follow-up of 7.5 years (from second weight assessment onward). High weight gain (Q5: 0.83-4.98 kg/year) was related to a slightly, but significantly higher breast cancer risk (HRQ5_versus_Q2/3: 1.09, 95% CI: 1.01-1.18). The association was more pronounced for breast cancer diagnosed before or at age 50 (HRQ5_versus_Q2/3: 1.37, 95% CI: 1.02-1.85). Weight loss was not associated with breast cancer risk. There was no evidence for heterogeneity by hormone receptor status. In conclusion, high weight gain in middle adulthood increases the risk of breast cancer. The association seems to be more pronounced for breast cancer diagnosed before or at age 50. Our results illustrate the importance of avoiding weight gain in middle adulthood.

AB - Long-term weight gain (i.e., weight gain since age 20) has been related to higher risk of postmenopausal breast cancer, but a lower risk of premenopausal breast cancer. The effect of weight change in middle adulthood is unclear. We investigated the association between weight change in middle adulthood (i.e., women aged 40-50 years) and the risk of breast cancer before and after the age of 50. We included female participants of the European Prospective Investigation into Cancer and Nutrition cohort, with information on anthropometric measures at recruitment and after a median follow-up of 4.3 years. Annual weight change was categorized using quintiles taking quintile 2 and 3 as the reference category (-0.44 to 0.36 kg/year). Multivariable Cox proportional hazards regression analysis was used to examine the association. 205,723 women were included and 4,663 incident breast cancer cases were diagnosed during a median follow-up of 7.5 years (from second weight assessment onward). High weight gain (Q5: 0.83-4.98 kg/year) was related to a slightly, but significantly higher breast cancer risk (HRQ5_versus_Q2/3: 1.09, 95% CI: 1.01-1.18). The association was more pronounced for breast cancer diagnosed before or at age 50 (HRQ5_versus_Q2/3: 1.37, 95% CI: 1.02-1.85). Weight loss was not associated with breast cancer risk. There was no evidence for heterogeneity by hormone receptor status. In conclusion, high weight gain in middle adulthood increases the risk of breast cancer. The association seems to be more pronounced for breast cancer diagnosed before or at age 50. Our results illustrate the importance of avoiding weight gain in middle adulthood.

KW - breast cancer

KW - adult weight gain

KW - menopausal status

KW - estrogen receptor

KW - progesterone receptor

U2 - 10.1002/ijc.28926

DO - 10.1002/ijc.28926

M3 - Article

C2 - 24771551

VL - 135

SP - 2887

EP - 2899

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 12

ER -