What's to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?

Research output: Contribution to journalArticle


α-Synuclein is a key protein in Parkinson disease. Not only is it the major protein component of Lewy bodies, but it is implicated in several cellular processes that are disrupted in Parkinson disease. Misfolded α-synuclein has also been shown to spread from cell-to-cell and, in a prion-like fashion, trigger aggregation of α-synuclein in the recipient cell. In this mini-review we explore the evidence that misfolded α-synuclein underlies the spread of pathology in Parkinson disease and discuss why it should be considered a prion-like protein.


  • Christopher Dunning
  • Sonia George
  • Patrik Brundin
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences


  • protein misfolding, cell-to-cell transfer, Parkinson disease, alpha-synuclein, prion-like
Original languageEnglish
Pages (from-to)92-97
Issue number1
Publication statusPublished - 2013
Publication categoryResearch

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)