Who let the dogs out?: detrimental role of Galectin-3 in hypoperfusion-induced retinal degeneration.

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Abstract

Retinal ischemia results in a progressive degeneration of neurons and a pathological activation of glial cells, resulting in vision loss. In the brain, progressive damage after ischemic insult has been correlated to neuroinflammatory processes involving microglia. Galectin-3 has been shown to mediate microglial responses to ischemic injury in the brain. Therefore, we wanted to explore the contribution of Galectin-3 (Gal-3) to hypoperfusion-induced retinal degeneration in mice.

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  • Neurology
Original languageEnglish
Article number92
JournalJournal of Neuroinflammation
Volume12
Issue number1
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes