Why Do Sex Chromosomes Stop Recombining?

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Why Do Sex Chromosomes Stop Recombining? / Ponnikas, Suvi; Sigeman, Hanna; Abbott, Jessica K.; Hansson, Bengt.

In: Trends in Genetics, Vol. 34, No. 7, 07.2018, p. 492-503.

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TY - JOUR

T1 - Why Do Sex Chromosomes Stop Recombining?

AU - Ponnikas, Suvi

AU - Sigeman, Hanna

AU - Abbott, Jessica K.

AU - Hansson, Bengt

PY - 2018/7

Y1 - 2018/7

N2 - It is commonly assumed that sex chromosomes evolve recombination suppression because selection favours linkage between sex-determining and sexually antagonistic genes. However, although the role of sexual antagonism during sex chromosome evolution has attained strong support from theory, experimental and observational evidence is rare or equivocal. Here, we highlight alternative, often neglected, hypotheses for recombination suppression on sex chromosomes, which invoke meiotic drive, heterozygote advantage, and genetic drift, respectively. We contrast the hypotheses, the situations when they are likely to be of importance, and outline why it is surprisingly difficult to test them. Lastly, we discuss future research directions (including modelling, population genomics, comparative approaches, and experiments) to disentangle the different hypotheses of sex chromosome evolution.

AB - It is commonly assumed that sex chromosomes evolve recombination suppression because selection favours linkage between sex-determining and sexually antagonistic genes. However, although the role of sexual antagonism during sex chromosome evolution has attained strong support from theory, experimental and observational evidence is rare or equivocal. Here, we highlight alternative, often neglected, hypotheses for recombination suppression on sex chromosomes, which invoke meiotic drive, heterozygote advantage, and genetic drift, respectively. We contrast the hypotheses, the situations when they are likely to be of importance, and outline why it is surprisingly difficult to test them. Lastly, we discuss future research directions (including modelling, population genomics, comparative approaches, and experiments) to disentangle the different hypotheses of sex chromosome evolution.

KW - heterozygote advantage

KW - meiotic drive

KW - recombination suppression

KW - sex chromosome

KW - sex determination

KW - sexual antagonism

UR - http://www.scopus.com/inward/record.url?scp=85046168465&partnerID=8YFLogxK

U2 - 10.1016/j.tig.2018.04.001

DO - 10.1016/j.tig.2018.04.001

M3 - Article

VL - 34

SP - 492

EP - 503

JO - Trends in Genetics

T2 - Trends in Genetics

JF - Trends in Genetics

SN - 1362-4555

IS - 7

ER -