Xylosylated naphthoic acid-amino acid conjugates for investigation of glycosaminoglycan priming.

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Xylosylated naphthoic acid-amino acid conjugates for investigation of glycosaminoglycan priming. / Abrahamsson, Carl-Olof; Ellervik, Ulf; Eriksson Bajtner, Johan; Jacobsson, Mårten; Mani, Katrin.

In: Carbohydrate Research, Vol. 343, No. 9, 2008, p. 1473-1477.

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Abrahamsson, Carl-Olof ; Ellervik, Ulf ; Eriksson Bajtner, Johan ; Jacobsson, Mårten ; Mani, Katrin. / Xylosylated naphthoic acid-amino acid conjugates for investigation of glycosaminoglycan priming. In: Carbohydrate Research. 2008 ; Vol. 343, No. 9. pp. 1473-1477.

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TY - JOUR

T1 - Xylosylated naphthoic acid-amino acid conjugates for investigation of glycosaminoglycan priming.

AU - Abrahamsson, Carl-Olof

AU - Ellervik, Ulf

AU - Eriksson Bajtner, Johan

AU - Jacobsson, Mårten

AU - Mani, Katrin

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Experimental Medical Science (013210000), Organic chemistry (S/LTH) (011001240), Glycobiology (013212006)

PY - 2008

Y1 - 2008

N2 - Three different series of xylosylated naphthoic acid-amino acid conjugates containing one or two amino acid residues were synthesized for the investigation of glycosaminoglycan priming and potential use as anti-tumor drugs. All xylosylated naphthoic acid-conjugates inhibited the growth of normal lung fibroblasts to some extent, whereas the growth of tumor derived T24 carcinoma cells was not affected. There was no correlation between amino acid conjugation, retention time and the antiproliferative activity. Only one compound initiated the priming of glycosaminoglycans. Modification of the naphthalene ring with one or two amino acid residues did not have any effect on proteoglycan biosynthesis or glycosaminoglycan priming in T24 carcinoma cells.

AB - Three different series of xylosylated naphthoic acid-amino acid conjugates containing one or two amino acid residues were synthesized for the investigation of glycosaminoglycan priming and potential use as anti-tumor drugs. All xylosylated naphthoic acid-conjugates inhibited the growth of normal lung fibroblasts to some extent, whereas the growth of tumor derived T24 carcinoma cells was not affected. There was no correlation between amino acid conjugation, retention time and the antiproliferative activity. Only one compound initiated the priming of glycosaminoglycans. Modification of the naphthalene ring with one or two amino acid residues did not have any effect on proteoglycan biosynthesis or glycosaminoglycan priming in T24 carcinoma cells.

U2 - 10.1016/j.carres.2008.04.006

DO - 10.1016/j.carres.2008.04.006

M3 - Article

VL - 343

SP - 1473

EP - 1477

JO - Carbohydrate Research

JF - Carbohydrate Research

SN - 1873-426X

IS - 9

ER -