Xylylated dimers of putrescine and polyamines: influence of the polyamine backbone on spermidine transport inhibition

Research output: Contribution to journalArticle


Dimeric norspermidine and spermidine derivatives are strong competitive inhibitors of polyamine transport. A xylyl tether was used for the dimerization of various triamines and spermine via a secondary amino group, and of putrescine via an ether or an amino group. Dimerization of putrescine moieties potentiates their ability to compete against spermidine transport to a much greater extent than for triamine dimers.


  • Laurence Covassin
  • Michel Desjardins
  • Denis Soulet
  • Rene Charest-Gaudreault
  • Marie Audette
  • Richard Poulin
External organisations
  • External Organization - Unknown
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences
Original languageEnglish
Pages (from-to)3267-3271
JournalBioorganic & Medicinal Chemistry Letters
Issue number19
Publication statusPublished - 2003
Publication categoryResearch
Externally publishedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)