Journal of Medicinal and Pharmaceutical Chemistry, 1520-4804

Tidskrift

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  1. 2018
  2. Elucidation of Hydrogen Bonding Patterns in Ligand-Free, Lactose- and Glycerol-Bound Galectin-3C by Neutron Crystallography to Guide Drug Design

    Francesco Manzoni, Johan Wallerstein, Tobias E Schrader, Andreas Ostermann, Leighton Coates, Mikael Akke, Matthew P Blakeley, Esko Oksanen & Derek T Logan, 2018 maj 24, I : Journal of Medicinal Chemistry. 61, 10, s. 4412-4420 9 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  3. Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity

    Kristoffer Peterson, Rohit Kumar, Olof Stenström, Priya Verma, Prashant R. Verma, Maria Håkansson, Barbro Kahl-Knutsson, Fredrik Zetterberg, Hakon Leffler, Mikael Akke, Derek T. Logan & Ulf J. Nilsson, 2018 feb 8, I : Journal of Medicinal Chemistry. 61, 3, s. 1164-1175 12 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  4. 2017
  5. Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space

    Axel Rudling, Robert Gustafsson, Ingrid Almlöf, Evert Homan, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark & Jens Carlsson, 2017 okt 12, I : Journal of Medicinal Chemistry. 60, 19, s. 8160-8169

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  6. 2016
  7. Active Site Mapping of an Aspartic Protease by Multiple Fragment Crystal Structures: Versatile Warheads to Address a Catalytic Dyad

    Nedyalka Radeva, Johannes Schiebel, Xiaojie Wang, Stefan G. Krimmer, Kan Fu, Martin Stieler, Frederik R. Ehrmann, Alexander Metz, Thomas Rickmeyer, Michael Betz, Johan Winquist, Ah Young Park, Franziska U. Huschmann, Manfred S. Weiss, Uwe Müller, Andreas Heine & Gerhard Klebe, 2016 nov 10, I : Journal of Medicinal Chemistry. 59, 21, s. 9743-9759 17 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  8. A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model

    Vishal Kumar Rajput, Alison MacKinnon, Santanu Mandal, Patrick Collins, Helen Blanchard, Hakon Leffler, Tariq Sethi, Hans Schambye, Balaram Mukhopadhyay & Ulf J. Nilsson, 2016 sep 8, I : Journal of Medicinal Chemistry. 59, 17, s. 8141-8147 7 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  9. Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis

    Katharina Brunner, Selma Maric, Rudraraju Srilakshmi Reshma, Helena Almqvist, Brinton Seashore-Ludlow, Anna-Lena Gustavsson, Ömer Poyraz, Perumal Yogeeswari, Thomas Lundbäck, Michaela Vallin, Dharmarajan Sriram, Robert Schnell & Gunter Schneider, 2016 jul 28, I : Journal of Medicinal Chemistry. 59, 14, s. 6848-59 12 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  10. Experimental Active-Site Mapping by Fragments - Hot Spots Remote from the Catalytic Center of Endothiapepsin

    Nedyalka Radeva, Stefan G Krimmer, Martin Stieler, Kan Fu, Xiaojie Wang, Frederik R Ehrmann, Alexander Metz, Franziska U Huschmann, Manfred S Weiss, Uwe Mueller, Johannes Schiebel, Andreas Heine & Gerhard Klebe, 2016 jul 27, I : Journal of Medicinal Chemistry.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  11. Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation.

    Henrik Sundén, Anja Schäfer, Marcel Scheepstra, Seppe Leysen, Marcus Malo, Jian-Nong Ma, Ethan S Burstein, Christian Ottmann, Luc Brunsveld & Roger Olsson, 2016, I : Journal of Medicinal Chemistry. 59, 3, s. 1232-1238

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  12. Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors

    Ewa Szymanska, Karla Andrea Frydenvang, Darryl S Pickering, Christian Krintel, Anne-Birgitte Nielsen, Ayesheh Kooshki, Linda Grønborg Zachariassen, Lars Olsen, Jette Sandholm Jensen Kastrup & Tommy Nørskov Johansen, 2016, I : Journal of Medicinal Chemistry. 59, 1, s. 448-461

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  13. 2015
  14. Disubstituted Bis-THF Moieties as New P2 Ligands in Nonpeptidal HIV-1 Protease Inhibitors (II)

    Konrad Hohlfeld, Joerg Kurt Wegner, Bart Kesteleyn, Bruno Linclau & Johan Unge, 2015, I : Journal of Medicinal Chemistry. 58, 9, s. 4029-4038

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  15. Synthesis and Biological Evaluation of Second-Generation Tropanol-Based Androgen Receptor Modulators

    Henrik Sunden, Mareike C. Holland, Pekka K. Poutiainen, Tiina Jaaskelainen, Juha T. Pulkkinen, Jorma J. Palvimo & Roger Olsson, 2015, I : Journal of Medicinal Chemistry. 58, 3, s. 1569-1574

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  16. 2014
  17. Synthesis of P1 '-Functionalized Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol

    Maria De Rosa, Johan Unge, Hitesh V. Motwani, Asa Rosenquist, Lotta Vrang, Hans Wallberg & Mats Larhed, 2014, I : Journal of Medicinal Chemistry. 57, 15, s. 6444-6457

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  18. 2013
  19. Design and Synthesis of P1-P3 Macrocyclic Tertiary-Alcohol-Comprising HIV-1 Protease Inhibitors

    Advait Joshi, Jean-Baptiste Veron, Johan Unge, Asa Rosenquist, Hans Wallberg, Bertil Samuelsson, Anders Hallberg & Mats Larhed, 2013, I : Journal of Medicinal Chemistry. 56, 22, s. 8999-9007

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  20. Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3, 4-dihydro-2 H-1, 2, 4-benzothiadiazine 1, 1-dioxide scaffold

    Ann-Beth Nørholm, Pierre Francotte, Lars Olsen, Christian Krintel, Karla Frydenvang, Eric Goffin, Sylvie Challal, Laurence Danober, Iuliana Botez-Pop, Pierre Lestage, Bernard Pirotte & Jette S Kastrup, 2013, I : Journal of Medicinal Chemistry. 56, 21, s. 8736-8745 10 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  21. Tuning the Preference of Thiodigalactoside- and Lactosamine-Based Ligands to Galectin-3 over Galectin-1

    Hilde van Hattum, Hilbert M. Branderhorst, Ed E. Moret, Ulf Nilsson, Hakon Leffler & Roland J. Pieters, 2013, I : Journal of Medicinal Chemistry. 56, 3, s. 1350-1354

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  22. 2012
  23. Selective mode of action of guanidine-containing non-peptides at human NPFF receptors

    Maria Findeisen, Cäcilia Würker, Daniel Rathmann, René Meier, Jens Meiler, Roger Olsson & Annette G. Beck-Sickinger, 2012 jul 12, I : Journal of Medicinal Chemistry. 55, 13, s. 6124-6136

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  24. Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors

    Xiongyu Wu, Per Ohrngren, Advait A. Joshi, Alejandro Trejos, Magnus Persson, Riina K. Arvela, Hans Wallberg, Lotta Vrang, Asa Rosenquist, Bertil B. Samuelsson, Johan Unge & Mats Larhed, 2012, I : Journal of Medicinal Chemistry. 55, 6, s. 2724-2736

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  25. 2011
  26. Difluoromethylbenzoxazole Pyrimidine Thioether Derivatives: A Novel Class of Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

    Jeremie Boyer, Eric Arnoult, Maurice Medebielle, Jerome Guillemont, Johan Unge & Dirk Jochmans, 2011, I : Journal of Medicinal Chemistry. 54, 23, s. 7974-7985

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  27. Molecular Wipes: Application to Epidemic Keratoconjuctivitis

    Karolina Aplander, Marko Marttila, Sophie Manner, Niklas Arnberg, Olov Sterner & Ulf Ellervik, 2011, I : Journal of Medicinal Chemistry. 54, 19, s. 6670-6675

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  28. 2009
  29. Discovery of selective nonpeptidergic neuropeptide FF2 receptor agonists

    Gilles Gaubert, Fabio Bertozzi, Nicholas M. Kelly, Jan Pawlas, Audra L. Scully, Norman R. Nash, Luis R. Gardell, Jelveh Lameh & Roger Olsson, 2009 nov 12, I : Journal of Medicinal Chemistry. 52, 21, s. 6511-6514

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  30. Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators

    Nathalie Schlienger, Birgitte W. Lund, Jan Pawlas, Fabrizio Badalassi, Fabio Bertozzi, Rasmus Lewinsky, Alma Fejzic, Mikkel B. Thygesen, Ali Tabatabaei, Stefania Risso Bradley, Luis R. Gardell, Fabrice Piu & Roger Olsson, 2009 okt 26, I : Journal of Medicinal Chemistry. 52, 22, s. 7186-7191

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  31. Synthesis and evaluation of dibenzothiazepines: A novel class of selective cannabinoid-1 receptor inverse agonists

    Hanna Pettersson, Anne Bülow, Fredrik Ek, Jacob Jensen, Lars K. Ottesen, Alma Fejzic, Jian Nong Ma, Andria L.Del Tredici, Erika A. Currier, Luis R. Gardell, Ali Tabatabaei, Darren Craig, Krista McFarland, Thomas R. Ott, Fabrice Piu, Ethan S. Burstein & Roger Olsson, 2009 apr 9, I : Journal of Medicinal Chemistry. 52, 7, s. 1975-1982 8 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  32. Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor β ligands

    Birgitte W. Lund, Anne Eeg Knapp, Fabrice Piu, Natalie K. Gauthier, Mikael Begtrup, Uli Hacksell & Roger Olsson, 2009 mar 26, I : Journal of Medicinal Chemistry. 52, 6, s. 1540-1545 6 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  33. 2008
  34. Discovery of potent and selective small-molecule PAR-2 agonists

    Jimmi Gerner Seitzberg, Anne Eeg Knapp, Birgitte Winther Lund, Sine Mandrup Bertozzi, Erika A. Currier, Jian Nong Ma, Vladimir Sherbukhin, Ethan S. Burstein & Roger Olsson, 2008 sep 25, I : Journal of Medicinal Chemistry. 51, 18, s. 5490-5493 4 s.

    Forskningsoutput: TidskriftsbidragDebate/Note/Editorial

  35. Arginine Binding Motifs: Design and Synthesis of Galactose-Derived Arginine Tweezers as Galectin-3 Inhibitors.

    Christopher Öberg, Hakon Leffler & Ulf Nilsson, 2008, I : Journal of Medicinal Chemistry. 51, 7, s. 2297-2301

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  36. Galectin-inhibitory thiodigalactoside ester derivatives have antimigratory effects in cultured lung and prostate cancer cells.

    Tamara Delaine, Ian Cumpstey, Laurent Ingrassia, Marie Le Mercier, Paul Okechukwu, Hakon Leffler, Robert Kiss & Ulf Nilsson, 2008, I : Journal of Medicinal Chemistry. 51, 24, s. 8109-8114

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  37. 2007
  38. Probing Molecular Interactions within Class II MHC A(q)/Glycopeptide/T-Cell Receptor Complexes Associated with Collagen-Induced Arthritis.

    Ida Andersson, Balik Dzhambazov, Rikard Holmdahl, Anna Linusson & Jan Kihlberg, 2007, I : Journal of Medicinal Chemistry. 50, 23, s. 5627-5643

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  39. Quantitative Structure-Activity Relationship of Peptides Binding to the Class II Major Histocompatibility Complex Molecule A(q) Associated with Autoimmune Arthritis.

    Lotta Holm, Kristina Frech, Balik Dzhambazov, Rikard Holmdahl, Jan Kihlberg & Anna Linusson, 2007, I : Journal of Medicinal Chemistry. 50, 9, s. 2049-2059

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  40. Synthesis and transfection efficiencies of new lipophilic polyamines

    Richard Andrew Gardner, Mattias Belting, Katrin Svensson & Otto Phanstiel, 2007, I : Journal of Medicinal Chemistry. 50, 2, s. 308-318

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  41. 2006
  42. Novel potent and efficacious nonpeptidic urotensin II receptor agonists

    Fredrik Lehmann, Anna Pettersen, Erika A. Currier, Vladimir Sherbukhin, Roger Olsson, Uli Hacksell & Kristina Luthman, 2006 apr 6, I : Journal of Medicinal Chemistry. 49, 7, s. 2232-2240 9 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  43. 4-quinolone derivatives: High-affinity ligands at the benzodiazepine site of brain GABA(A) receptors. synthesis, pharmacology, and pharmacophore modeling

    Erik Lager, P Andersson, Jakob Nilsson, I Pettersson, EO Nielsen, M Nielsen, Olov Sterner & T Liljefors, 2006, I : Journal of Medicinal Chemistry. 49, 8, s. 2526-2533

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  44. Ligand affinities predicted with the MM/PBSA method: Dependence on the simulation method and the force field

    Aaron Weis, Kambiz Katebzadeh, Pär Söderhjelm, Ingemar Nilsson & Ulf Ryde, 2006, I : Journal of Medicinal Chemistry. 49, 22, s. 6596-6606

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  45. Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits

    Trond Ulven, Jean-Marie Receveur, Marie Grimstrup, Oystein Rist, Thomas M Frimurer, Lars-Ole Gerlach, Jesper Mosolff Mathiesen, Evi Kostenis, Lena Uller & Thomas Hogberg, 2006, I : Journal of Medicinal Chemistry. 49, 23, s. 6638-6641

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  46. Prediction of activation energies for hydrogen abstraction by cytochrome P450

    Lars Olsen, Patrik Rydberg, Thomas H. Rod & Ulf Ryde, 2006, I : Journal of Medicinal Chemistry. 49, 22, s. 6489-6499

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  47. Selective antiproliferative activity of hydroxynaphthyl-beta-D-xylosides

    Mårten Jacobsson, Ulf Ellervik, Mattias Belting & Katrin Mani, 2006, I : Journal of Medicinal Chemistry. 49, 6, s. 1932-1938

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  48. 2005
  49. Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist

    Birgitte W. Lund, Fabrice Piu, Natalie K. Gauthier, Anne Eeg, Erika Currier, Vladimir Sherbukhin, Mark R. Brann, Uli Hacksell & Roger Olsson, 2005 nov 4, I : Journal of Medicinal Chemistry. 48, 24, s. 7517-7519

    Forskningsoutput: TidskriftsbidragLetter

  50. Light-Induced Anticancer Activity of [RuCl2(DMSO)4] Complexes

    Malgorzata Brindell, E Kulis, Sofi Elmroth, K Urbanska & G Stochel, 2005, I : Journal of Medicinal Chemistry. 48, 23, s. 7298-7304

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  51. 2002
  52. Discovery of the first nonpeptide agonist of the GPR14/Urotensin-II receptor: 3-(4-Chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one (AC-7954)

    Glenn E. Croston, Roger Olsson, Erika A. Currier, Ethan S. Burstein, David Weiner, Norman Nash, Daniel Severance, Stig G. Allenmark, Linda Thunberg, Jian Nong Ma, Nina Mohell, Brian O'Dowd, Mark R. Brann & Uli Hacksell, 2002 okt 9, I : Journal of Medicinal Chemistry. 45, 23, s. 4950-4953

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  53. Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases

    Ewa Wieczerzak, P Drabik, L Lankiewicz, S Oldziej, Z Grzonka, Magnus Abrahamson, Anders Grubb & D Bromme, 2002, I : Journal of Medicinal Chemistry. 45, 19, s. 4202-4211

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  54. Methanocarba modification of uracil and adenine nucleotides: High potency of northern ring conformation at P2Y(1), P2Y(2), P2Y(4), and P2Y(11) but not P2Y(6) receptors

    HS Kim, RG Ravi, VE Marquez, S Maddileti, Anna-Karin Wihlborg, David Erlinge, Malin Malmsjö, JL Boyer, TK Harden & KA Jacobson, 2002, I : Journal of Medicinal Chemistry. 45, 1, s. 208-218

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  55. Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor

    Pia Kahnberg, Erik Lager, Celia Rosenberg, Jette Schougaard, Linda Camet, Olov Sterner, Elisabet Ostergaard Nielsen, Mogens Nielsen & Tommy Liljefors, 2002, I : Journal of Medicinal Chemistry. 45, 19, s. 4188-4201

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  56. 2000
  57. Computational predictions of binding affinities to dihydrofolate reductase: synthesis and biological evaluation of methotrexate analogues

    M Graffner-Nordberg, J Marelius, S Ohlsson, A Persson, G Swedberg, P Andersson, Sven Andersson, J Aqvist & A Hallberg, 2000, I : Journal of Medicinal Chemistry. 43, 21, s. 3852-3861

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift