Journal of Medicinal and Pharmaceutical Chemistry, 1520-4804

Tidskrift

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  1. 2018
  2. Elucidation of Hydrogen Bonding Patterns in Ligand-Free, Lactose- and Glycerol-Bound Galectin-3C by Neutron Crystallography to Guide Drug Design

    Manzoni, F., Johan Wallerstein, Schrader, T. E., Ostermann, A., Coates, L., Mikael Akke, Blakeley, M. P., Oksanen, E. & Derek T Logan, 2018 maj 24, I : Journal of Medicinal Chemistry. 61, 10, s. 4412-4420 9 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  3. Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity

    Peterson, K., Rohit Kumar, Olof Stenström, Verma, P., Verma, P. R., Håkansson, M., Kahl-Knutsson, B., Zetterberg, F., Hakon Leffler, Mikael Akke, Derek T. Logan & Ulf J. Nilsson, 2018 feb 8, I : Journal of Medicinal Chemistry. 61, 3, s. 1164-1175 12 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  4. 2017
  5. Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space

    Rudling, A., Gustafsson, R., Almlöf, I., Homan, E., Scobie, M., Warpman Berglund, U., Helleday, T., Pål Stenmark & Carlsson, J., 2017 okt 12, I : Journal of Medicinal Chemistry. 60, 19, s. 8160-8169

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  6. 2016
  7. Active Site Mapping of an Aspartic Protease by Multiple Fragment Crystal Structures: Versatile Warheads to Address a Catalytic Dyad

    Radeva, N., Schiebel, J., Wang, X., Krimmer, S. G., Fu, K., Stieler, M., Ehrmann, F. R., Metz, A., Rickmeyer, T., Betz, M., Winquist, J., Park, A. Y., Huschmann, F. U., Weiss, M. S., Uwe Müller, Heine, A. & Klebe, G., 2016 nov 10, I : Journal of Medicinal Chemistry. 59, 21, s. 9743-9759 17 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  8. A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model

    Rajput, V. K., MacKinnon, A., Mandal, S., Collins, P., Blanchard, H., Hakon Leffler, Sethi, T., Schambye, H., Mukhopadhyay, B. & Nilsson, U. J., 2016 sep 8, I : Journal of Medicinal Chemistry. 59, 17, s. 8141-8147 7 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  9. Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis

    Brunner, K., Selma Maric, Reshma, R. S., Almqvist, H., Seashore-Ludlow, B., Gustavsson, A-L., Poyraz, Ö., Yogeeswari, P., Lundbäck, T., Vallin, M., Sriram, D., Schnell, R. & Schneider, G., 2016 jul 28, I : Journal of Medicinal Chemistry. 59, 14, s. 6848-59 12 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  10. Experimental Active-Site Mapping by Fragments - Hot Spots Remote from the Catalytic Center of Endothiapepsin

    Radeva, N., Krimmer, S. G., Stieler, M., Fu, K., Wang, X., Ehrmann, F. R., Metz, A., Huschmann, F. U., Weiss, M. S., Mueller, U., Schiebel, J., Heine, A. & Klebe, G., 2016 jul 27, I : Journal of Medicinal Chemistry.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  11. Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation.

    Sundén, H., Schäfer, A., Scheepstra, M., Leysen, S., Malo, M., Ma, J-N., Burstein, E. S., Ottmann, C., Brunsveld, L. & Roger Olsson, 2016, I : Journal of Medicinal Chemistry. 59, 3, s. 1232-1238

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  12. Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors

    Szymanska, E., Frydenvang, K. A., Pickering, D. S., Christian Krintel, Nielsen, A-B., Kooshki, A., Zachariassen, L. G., Olsen, L., Kastrup, J. S. J. & Johansen, T. N., 2016, I : Journal of Medicinal Chemistry. 59, 1, s. 448-461

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  13. 2015
  14. Disubstituted Bis-THF Moieties as New P2 Ligands in Nonpeptidal HIV-1 Protease Inhibitors (II)

    Hohlfeld, K., Wegner, J. K., Kesteleyn, B., Linclau, B. & Johan Unge, 2015, I : Journal of Medicinal Chemistry. 58, 9, s. 4029-4038

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  15. Synthesis and Biological Evaluation of Second-Generation Tropanol-Based Androgen Receptor Modulators

    Sunden, H., Holland, M. C., Poutiainen, P. K., Jaaskelainen, T., Pulkkinen, J. T., Palvimo, J. J. & Roger Olsson, 2015, I : Journal of Medicinal Chemistry. 58, 3, s. 1569-1574

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  16. 2014
  17. Synthesis of P1 '-Functionalized Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol

    De Rosa, M., Johan Unge, Motwani, H. V., Rosenquist, A., Vrang, L., Wallberg, H. & Larhed, M., 2014, I : Journal of Medicinal Chemistry. 57, 15, s. 6444-6457

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  18. 2013
  19. Design and Synthesis of P1-P3 Macrocyclic Tertiary-Alcohol-Comprising HIV-1 Protease Inhibitors

    Joshi, A., Veron, J-B., Johan Unge, Rosenquist, A., Wallberg, H., Samuelsson, B., Hallberg, A. & Larhed, M., 2013, I : Journal of Medicinal Chemistry. 56, 22, s. 8999-9007

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  20. Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3, 4-dihydro-2 H-1, 2, 4-benzothiadiazine 1, 1-dioxide scaffold

    Nørholm, A-B., Francotte, P., Olsen, L., Christian Krintel, Frydenvang, K., Goffin, E., Challal, S., Danober, L., Botez-Pop, I., Lestage, P., Pirotte, B. & Kastrup, J. S., 2013, I : Journal of Medicinal Chemistry. 56, 21, s. 8736-8745 10 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  21. Tuning the Preference of Thiodigalactoside- and Lactosamine-Based Ligands to Galectin-3 over Galectin-1

    van Hattum, H., Branderhorst, H. M., Moret, E. E., Ulf Nilsson, Hakon Leffler & Pieters, R. J., 2013, I : Journal of Medicinal Chemistry. 56, 3, s. 1350-1354

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  22. 2012
  23. Selective mode of action of guanidine-containing non-peptides at human NPFF receptors

    Findeisen, M., Würker, C., Rathmann, D., Meier, R., Meiler, J., Roger Olsson & Beck-Sickinger, A. G., 2012 jul 12, I : Journal of Medicinal Chemistry. 55, 13, s. 6124-6136

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  24. Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors

    Wu, X., Ohrngren, P., Joshi, A. A., Trejos, A., Persson, M., Arvela, R. K., Wallberg, H., Vrang, L., Rosenquist, A., Samuelsson, B. B., Johan Unge & Larhed, M., 2012, I : Journal of Medicinal Chemistry. 55, 6, s. 2724-2736

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  25. 2011
  26. Difluoromethylbenzoxazole Pyrimidine Thioether Derivatives: A Novel Class of Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

    Boyer, J., Arnoult, E., Medebielle, M., Guillemont, J., Johan Unge & Jochmans, D., 2011, I : Journal of Medicinal Chemistry. 54, 23, s. 7974-7985

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  27. Molecular Wipes: Application to Epidemic Keratoconjuctivitis

    Aplander, K., Marttila, M., Sophie Manner, Arnberg, N., Olov Sterner & Ulf Ellervik, 2011, I : Journal of Medicinal Chemistry. 54, 19, s. 6670-6675

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  28. 2009
  29. Discovery of selective nonpeptidergic neuropeptide FF2 receptor agonists

    Gaubert, G., Bertozzi, F., Kelly, N. M., Pawlas, J., Scully, A. L., Nash, N. R., Gardell, L. R., Lameh, J. & Roger Olsson, 2009 nov 12, I : Journal of Medicinal Chemistry. 52, 21, s. 6511-6514

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  30. Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators

    Schlienger, N., Lund, B. W., Pawlas, J., Badalassi, F., Bertozzi, F., Lewinsky, R., Fejzic, A., Thygesen, M. B., Tabatabaei, A., Bradley, S. R., Gardell, L. R., Piu, F. & Roger Olsson, 2009 okt 26, I : Journal of Medicinal Chemistry. 52, 22, s. 7186-7191

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  31. Synthesis and evaluation of dibenzothiazepines: A novel class of selective cannabinoid-1 receptor inverse agonists

    Pettersson, H., Bülow, A., Fredrik Ek, Jensen, J., Ottesen, L. K., Fejzic, A., Ma, J. N., Tredici, A. L. D., Currier, E. A., Gardell, L. R., Tabatabaei, A., Craig, D., McFarland, K., Ott, T. R., Piu, F., Burstein, E. S. & Roger Olsson, 2009 apr 9, I : Journal of Medicinal Chemistry. 52, 7, s. 1975-1982 8 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  32. Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor β ligands

    Lund, B. W., Knapp, A. E., Piu, F., Gauthier, N. K., Begtrup, M., Hacksell, U. & Roger Olsson, 2009 mar 26, I : Journal of Medicinal Chemistry. 52, 6, s. 1540-1545 6 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  33. 2008
  34. Discovery of potent and selective small-molecule PAR-2 agonists

    Seitzberg, J. G., Knapp, A. E., Lund, B. W., Bertozzi, S. M., Currier, E. A., Ma, J. N., Sherbukhin, V., Burstein, E. S. & Roger Olsson, 2008 sep 25, I : Journal of Medicinal Chemistry. 51, 18, s. 5490-5493 4 s.

    Forskningsoutput: TidskriftsbidragDebate/Note/Editorial

  35. Arginine Binding Motifs: Design and Synthesis of Galactose-Derived Arginine Tweezers as Galectin-3 Inhibitors.

    Öberg, C., Hakon Leffler & Ulf Nilsson, 2008, I : Journal of Medicinal Chemistry. 51, 7, s. 2297-2301

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  36. Galectin-inhibitory thiodigalactoside ester derivatives have antimigratory effects in cultured lung and prostate cancer cells.

    Delaine, T., Cumpstey, I., Ingrassia, L., Le Mercier, M., Okechukwu, P., Hakon Leffler, Kiss, R. & Ulf Nilsson, 2008, I : Journal of Medicinal Chemistry. 51, 24, s. 8109-8114

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  37. 2007
  38. Probing Molecular Interactions within Class II MHC A(q)/Glycopeptide/T-Cell Receptor Complexes Associated with Collagen-Induced Arthritis.

    Andersson, I., Dzhambazov, B., Holmdahl, R., Linusson, A. & Kihlberg, J., 2007, I : Journal of Medicinal Chemistry. 50, 23, s. 5627-5643

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  39. Quantitative Structure-Activity Relationship of Peptides Binding to the Class II Major Histocompatibility Complex Molecule A(q) Associated with Autoimmune Arthritis.

    Holm, L., Frech, K., Dzhambazov, B., Holmdahl, R., Kihlberg, J. & Linusson, A., 2007, I : Journal of Medicinal Chemistry. 50, 9, s. 2049-2059

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  40. Synthesis and transfection efficiencies of new lipophilic polyamines

    Gardner, R. A., Mattias Belting, Svensson, K. & Phanstiel, O., 2007, I : Journal of Medicinal Chemistry. 50, 2, s. 308-318

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  41. 2006
  42. Novel potent and efficacious nonpeptidic urotensin II receptor agonists

    Lehmann, F., Pettersen, A., Currier, E. A., Sherbukhin, V., Roger Olsson, Hacksell, U. & Luthman, K., 2006 apr 6, I : Journal of Medicinal Chemistry. 49, 7, s. 2232-2240 9 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  43. 4-quinolone derivatives: High-affinity ligands at the benzodiazepine site of brain GABA(A) receptors. synthesis, pharmacology, and pharmacophore modeling

    Lager, E., Andersson, P., Nilsson, J., Pettersson, I., Nielsen, EO., Nielsen, M., Olov Sterner & Liljefors, T., 2006, I : Journal of Medicinal Chemistry. 49, 8, s. 2526-2533

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  44. Ligand affinities predicted with the MM/PBSA method: Dependence on the simulation method and the force field

    Weis, A., Katebzadeh, K., Pär Söderhjelm, Nilsson, I. & Ulf Ryde, 2006, I : Journal of Medicinal Chemistry. 49, 22, s. 6596-6606

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  45. Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits

    Ulven, T., Receveur, J-M., Grimstrup, M., Rist, O., Frimurer, T. M., Gerlach, L-O., Mathiesen, J. M., Kostenis, E., Lena Uller & Hogberg, T., 2006, I : Journal of Medicinal Chemistry. 49, 23, s. 6638-6641

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  46. Prediction of activation energies for hydrogen abstraction by cytochrome P450

    Olsen, L., Rydberg, P., Rod, T. H. & Ulf Ryde, 2006, I : Journal of Medicinal Chemistry. 49, 22, s. 6489-6499

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  47. Selective antiproliferative activity of hydroxynaphthyl-beta-D-xylosides

    Jacobsson, M., Ulf Ellervik, Mattias Belting & Katrin Mani, 2006, I : Journal of Medicinal Chemistry. 49, 6, s. 1932-1938

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  48. 2005
  49. Light-Induced Anticancer Activity of [RuCl2(DMSO)4] Complexes

    Brindell, M., Kulis, E., Sofi Elmroth, Urbanska, K. & Stochel, G., 2005, I : Journal of Medicinal Chemistry. 48, 23, s. 7298-7304

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  50. 2002
  51. Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases

    Wieczerzak, E., Drabik, P., Lankiewicz, L., Oldziej, S., Grzonka, Z., Magnus Abrahamson, Anders Grubb & Bromme, D., 2002, I : Journal of Medicinal Chemistry. 45, 19, s. 4202-4211

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  52. Methanocarba modification of uracil and adenine nucleotides: High potency of northern ring conformation at P2Y(1), P2Y(2), P2Y(4), and P2Y(11) but not P2Y(6) receptors

    Kim, HS., Ravi, RG., Marquez, VE., Maddileti, S., Anna-Karin Wihlborg, David Erlinge, Malin Malmsjö, Boyer, JL., Harden, TK. & Jacobson, KA., 2002, I : Journal of Medicinal Chemistry. 45, 1, s. 208-218

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  53. Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor

    Kahnberg, P., Lager, E., Rosenberg, C., Schougaard, J., Camet, L., Olov Sterner, Ostergaard Nielsen, E., Nielsen, M. & Liljefors, T., 2002, I : Journal of Medicinal Chemistry. 45, 19, s. 4188-4201

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  54. 2000
  55. Computational predictions of binding affinities to dihydrofolate reductase: synthesis and biological evaluation of methotrexate analogues

    Graffner-Nordberg, M., Marelius, J., Ohlsson, S., Persson, A., Swedberg, G., Andersson, P., Andersson, S., Aqvist, J. & Hallberg, A., 2000, I : Journal of Medicinal Chemistry. 43, 21, s. 3852-3861

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift