Experimentell Epilepsi

Organisation: forskargrupp

Fler filtreringsmöjligheter
  1. 2020
  2. Advancing gene therapy for epilepsy. Translational pre-clinical studies with neuropeptide Y and glial cell-line derived neurotrophic factor.

    Esbjörn Melin, 2020, Lund: Lund University, Faculty of Medicine. 100 s.

    Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

  3. Development and Validation of CRISPR Activator Systems for Overexpression of CB1 Receptors in Neurons

    Valentina Di Maria, Marine Moindrot, Martin Ryde, Antonino Bono, Luis Quintino & Marco Ledri, 2020, I: Frontiers in Molecular Neuroscience. 13, 168.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  4. Gene Therapy Vector Encoding Neuropeptide Y and Its Receptor Y2 for Future Treatment of Epilepsy: Preclinical Data in Rats

    Julia Alicja Szczygieł, Kira Iben Danielsen, Esbjörn Melin, Søren Hofman Rosenkranz, Stanislava Pankratova, Annika Ericsson, Karin Agerman, Merab Kokaia & David Paul Drucker Woldbye, 2020, I: Frontiers in Molecular Neuroscience. 13, 232.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  5. 2019
  6. Disease Modification by Combinatorial Single Vector Gene Therapy: A Preclinical Translational Study in Epilepsy

    Esbjörn Melin, Avtandil Nanobashvili, Una Avdic, Casper R. Gøtzsche, My Andersson, David P.D. Woldbye & Merab Kokaia, 2019 dec 13, I: Molecular Therapy - Methods and Clinical Development. 15, s. 179-193 15 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  7. Advancing research toward faster diagnosis, better treatment, and end of stigma in epilepsy

    Asla Pitkänen, David C. Henshall, J. Helen Cross, Renzo Guerrini, Sergiusz Jozwiak, Merab Kokaia, Michele Simonato, Sanjay Sisodiya & Janet Mifsud, 2019, I: Epilepsia.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  8. Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients

    Jenny Wickham, Marco Ledri, Johan Bengzon, Bo Jespersen, Lars H. Pinborg, Elisabet Englund, David P.D. Woldbye, My Andersson & Merab Kokaia, 2019, I: Scientific Reports. 9, 1, 19393.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  9. Leaky Optoelectrical Fiber for Optogenetic Stimulation and Electrochemical Detection of Dopamine Exocytosis from Human Dopaminergic Neurons

    Shashank Vasudevan, Janko Kajtez, Ada Ioana Bunea, Ana Gonzalez-Ramos, Tania Ramos-Moreno, Arto Heiskanen, Merab Kokaia, Niels B. Larsen, Alberto Martínez-Serrano, Stephan S. Keller & Jenny Emnéus, 2019, I: Advanced Science. 6, 24, 1902011.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  10. Long-Term, Targeted Delivery of GDNF from Encapsulated Cells Is Neuroprotective and Reduces Seizures in the Pilocarpine Model of Epilepsy

    Giovanna Paolone, Chiara Falcicchia, Francesca Lovisari, Merab Kokaia, William J. Bell, Tracie Fradet, Mario Barbieri, Lars U. Wahlberg, Dwaine F. Emerich & Michele Simonato, 2019, I: The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 11, s. 2144-2156 13 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  11. Unilateral ex vivo gene therapy by GDNF in epileptic rats

    Avtandil Nanobashvili, Esbjörn Melin, Dwaine Emerich, Jens Tornøe, Michele Simonato, Lars Wahlberg & Merab Kokaia, 2019, I: Gene Therapy. 26, 3-4, s. 65-74

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  12. 2018
  13. Spatiotemporal pattern of Wnt-canonical pathway in dorsal telencephalic organoids.

    Ana Gonzalez Ramos, Jonothon Marshall & John O. Mason, 2018 jul 6, (Unpublished).

    Forskningsoutput: KonferensbidragPoster

  14. Preserved function of afferent parvalbumin-positive perisomatic inhibitory synapses of dentate granule cells in rapidly kindled mice

    Marita G. Hansen, Litsa N. Ledri, Deniz Kirik, Merab Kokaia & Marco Ledri, 2018 jan 9, I: Frontiers in Cellular Neuroscience. 11, 433.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  15. Bridging the gap in translational epilepsy research - A patient brain tissue platform for validating animal data

    Jenny Wickham, 2018, Lund: Lund University: Faculty of Medicine. 79 s.

    Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

  16. 2017
  17. Altered chloride homeostasis decreases the action potential threshold and increases hyperexcitability in hippocampal neurons

    Andreas T. Sørensen, Marco Ledri, Miriam Melis, Litsa Nikitidou Ledri, My Andersson & Merab Kokaia, 2017 nov 1, I: eNeuro. 4, 6, e0172-17.2017.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  18. Epilepsy and optogenetics: Can seizures be controlled by light?

    Jan Tönnesen & Merab Kokaia, 2017 jul 15, I: Clinical Science. 131, 14, s. 1605-1616 12 s.

    Forskningsoutput: TidskriftsbidragÖversiktsartikel

  19. 2016
  20. DREADDs suppress seizure-like activity in a mouse model of pharmacoresistant epileptic brain tissue

    N. Avaliani, M. Andersson, A. H. Runegaard, D. Woldbye & M. Kokaia, 2016 okt 1, I: Gene Therapy. 23, 10, s. 760-766 7 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  21. Advances in the development of biomarkers for epilepsy

    Asla Pitkänen, Wolfgang Löscher, Annamaria Vezzani, Albert J. Becker, Michele Simonato, Katarzyna Lukasiuk, Olli Gröhn, Jens P. Bankstahl, Alon Friedman, Eleonora Aronica, Jan A. Gorter, Teresa Ravizza, Sanjay M. Sisodiya, Merab Kokaia & Heinz Beck, 2016 jul 1, I: Lancet Neurology. 15, 8, s. 843-856 14 s.

    Forskningsoutput: TidskriftsbidragÖversiktsartikel

  22. Optogenetic control of human neurons in organotypic brain cultures

    My Andersson, Natalia Avaliani, Andreas Svensson, Jenny Wickham, Lars H. Pinborg, Bo Jespersen, Søren H. Christiansen, Johan Bengzon, David P D Woldbye & Merab Kokaia, 2016 apr 21, I: Scientific Reports. 6, 24818.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  23. Novel approaches to explore mechanisms of epileptic seizures - optogenetic and chemogenetic manipulation of hippocampal circuitry

    Fredrik Berglind, 2016, Experimental Epilepsy Group. 71 s.

    Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

  24. Translational approach for gene therapy in epilepsy: Model system and unilateral overexpression of neuropeptide Y and Y2 receptors.

    Litsa Nikitidou, Esbjörn Melin, Søren H Christiansen, Casper R Gøtzsche, Alessandra Cifra, David P D Woldbye & Merab Kokaia, 2016, I: Neurobiology of Disease. 86, nov 19, s. 52-61

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  25. 2015
  26. Chemogenetics, Induced Neurons and Pluripotent Stem Cells: Towards Advanced Gene and Cell Therapies Targeting Epilepsy

    Natalia Avaliani, 2015, Department of Clinical Sciences, Lund University. 75 s.

    Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

  27. Differential Effect of Neuropeptides on Excitatory Synaptic Transmission in Human Epileptic Hippocampus.

    Marco Ledri, Andreas T Sørensen, Marita Grönning Madsen, Søren H Christiansen, Litsa Nikitidou Ledri, Alessandra Cifra, Johan Bengzon, Eva Lindberg, Lars H Pinborg, Bo Jespersen, Casper R Gøtzsche, David P D Woldbye, My Andersson & Merab Kokaia, 2015, I: Journal of Neuroscience. 35, 26, s. 9622-9631

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  28. 2014
  29. A compact multifunctional microfluidic platform for exploring cellular dynamics in real-time using electrochemical detection

    K. Zor, A. Heiskanen, C. Caviglia, M. Vergani, E. Landini, F. Shah, M. Carminati, A. Martinez-Serrano, Tania Ramos Moreno, Merab Kokaia, D. Benayahu, Zs. Keresztes, D. Papkovsky, U. Wollenberger, W. E. Svendsen, M. Dimaki, G. Ferrari, R. Raiteri, M. Sampietro, M. Dufva & 1 andra, J. Emneus, 2014, I: RSC Advances. 4, 109, s. 63761-63771

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  30. Global Optogenetic Activation of Inhibitory Interneurons during Epileptiform Activity.

    Marco Ledri, Marita Grönning Madsen, Litsa Nikitidou, Deniz Kirik & Merab Kokaia, 2014, I: Journal of Neuroscience. 34, 9, s. 3364-3377

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  31. How Might Novel Technologies Such as Optogenetics Lead to Better Treatments in Epilepsy?

    Esther Krook-Magnuson, Marco Ledri, Ivan Soltesz & Merab Kokaia, 2014, Issues in Clinical Epileptology: A View From the Bench. Scharfman, H. E. & Buckmaster, P. S. (red.). Springer, Vol. 813. s. 319-336 (Advances in Experimental Medicine and Biology; vol. 813).

    Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKapitel samlingsverk

  32. Optogenetic inhibition of chemically induced hypersynchronized bursting in mice.

    Fredrik Berglind, Marco Ledri, Andreas Toft Sørensen, Litsa Nikitidou, Miriam Melis, Pascal Bielefeld, Deniz Kirik, Karl Deisseroth, My Andersson & Merab Kokaia, 2014, I: Neurobiology of Disease. 65, s. 133-141

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  33. Optogenetics reveal delayed afferent synaptogenesis on grafted human induced pluripotent stem cell-derived neural progenitors.

    Natalia Avaliani, Andreas Toft Sörensen, Marco Ledri, Johan Bengzon, Philipp Koch, Oliver Brüstle, Karl Deisseroth, My Andersson & Merab Kokaia, 2014, I: Stem Cells. 32, 12, s. 3088-3098

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  34. Quantitative mapping of the local and extrinsic sources of GABA and Reelin to the layer Ia neuropil in the adult rat neocortex

    Tania Ramos Moreno & Francisco Clasca, 2014, I: Brain Structure and Function. 219, 5, s. 1639-1657

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  35. 2013
  36. Epilepsy therapy development: Technical and methodologic issues in studies with animal models

    Aristea S. Galanopoulou, Merab Kokaia, Jeffrey A. Loeb, Astrid Nehlig, Asla Pitkanen, Michael A. Rogawski, Kevin J. Staley, Vicky H. Whittemore & F. Edward Dudek, 2013, I: Epilepsia. 54, s. 13-23

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  37. 2012
  38. Altered profile of basket cell afferent synapses in hyper-excitable dentate gyrus revealed by optogenetic and two-pathway stimulations.

    Marco Ledri, Litsa Nikitidou, Ferenc Erdelyi, Gabor Szabo, Deniz Kirik, Karl Deisseroth & Merab Kokaia, 2012, I: European Journal of Neuroscience. 36, 1, s. 1971-1983

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  39. Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures

    Casper R. Gotzsche, Litsa Nikitidou, Andreas Toft Sörensen, Mikkel V. Olesen, Gunnar Sorensen, Soren H. O. Christiansen, Mikael Ängehagen, David P. D. Woldbye & Merab Kokaia, 2012, I: Neurobiology of Disease. 45, 1, s. 288-296

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  40. VEGF receptor-2 (flk-1) overexpression in mice counteracts focal epileptic seizures.

    Litsa Nikitidou, Irene Kanter Schlifke, Joke Dhondt, Peter Carmeliet, Diether Lambrechts & Merab Kokaia, 2012, I: PLoS ONE. 7, 7, e40535.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  41. 2011
  42. Functional integration of grafted neural stem cell-derived dopaminergic neurons monitored by optogenetics in an in vitro Parkinson model.

    Jan Tønnesen, Clare L Parish, Andreas Toft Sörensen, Angelica Andersson, Cecilia Lundberg, Karl Deisseroth, Ernest Arenas, Olle Lindvall & Merab Kokaia, 2011, I: PLoS ONE. 6, 3, e17560.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  43. Tuning afferent synapses of hippocampal interneurons by neuropeptide Y.

    Marco Ledri, Andreas Toft Sörensen, Ferenc Erdelyi, Gabor Szabo & Merab Kokaia, 2011, I: Hippocampus. 21, s. 198-211

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  44. 2010
  45. Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures.

    David P D Woldbye, Mikael Ängehagen, Casper R Gøtzsche, Heidi Elbrønd-Bek, Andreas Toft Sörensen, Søren H Christiansen, Mikkel V Olesen, Litsa Nikitidou, Thomas V O Hansen, Irene Kanter Schlifke & Merab Kokaia, 2010, I: Brain. 133, Pt 9, s. 2778-2788

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  46. 2009
  47. Optogenetic control of epileptiform activity.

    Jan Tønnesen, Andreas Toft Sörensen, Karl Deisseroth, Cecilia Lundberg & Merab Kokaia, 2009, I: Proceedings of the National Academy of Sciences. 106, 29, s. 12162-12167

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  48. 2008
  49. Activity-dependent volume transmission by transgene NPY attenuates glutamate release and LTP in subiculum

    Andreas Toft Sörensen, Irene Kanter Schlifke, En-Ju D. Lin, Matthew J. During & Merab Kokaia, 2008, I: Molecular and Cellular Neuroscience. 39, 2, s. 229-37

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  50. Gene therapy for epilepsy: resculpturing synaptic transmission with neuropeptides

    Andreas Toft Sörensen, 2008, Institutionen för kliniska vetenskaper, Lunds universitet. 134 s.

    Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

  51. 2007
  52. Brain area, age and viral vector-specific glial cell-line-derived neurotrophic factor expression and transport in rat.

    Irene Kanter Schlifke, Biljana Georgievska, Deniz Kirik & Merab Kokaia, 2007, I: NeuroReport. 18, 9, s. 845-850

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  53. Seizure Suppression by GDNF Gene Therapy in Animal Models of Epilepsy.

    Irene Kanter Schlifke, Biljana Georgievska, Deniz Kirik & Merab Kokaia, 2007, I: Molecular Therapy. 15, s. 1106-1113

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  54. 1989
  55. Ethanol stimulates basal and serotonin-induced formation of [32P]phosphatidic acid in human platelets

    Per Simonsson, Istvan Ferencz & Christer Alling, 1989, I: Drug and Alcohol Dependence. 24, 2, s. 169-174

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift