Experimentell Epilepsi

Advancing gene therapy for epilepsy. Translational pre-clinical studies with neuropeptide Y and glial cell-line derived neurotrophic factor.

Esbjörn Melin, 2020, Lund: Lund University, Faculty of Medicine. 100 s.

Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

Development and Validation of CRISPR Activator Systems for Overexpression of CB1 Receptors in Neurons

Valentina Di Maria, Marine Moindrot, Martin Ryde, Antonino Bono, Luis Quintino & Marco Ledri, 2020, I: Frontiers in Molecular Neuroscience. 13, 168.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Gene Therapy Vector Encoding Neuropeptide Y and Its Receptor Y2 for Future Treatment of Epilepsy: Preclinical Data in Rats

Julia Alicja Szczygieł, Kira Iben Danielsen, Esbjörn Melin, Søren Hofman Rosenkranz, Stanislava Pankratova, Annika Ericsson, Karin Agerman, Merab Kokaia & David Paul Drucker Woldbye, 2020, I: Frontiers in Molecular Neuroscience. 13, 232.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Disease Modification by Combinatorial Single Vector Gene Therapy: A Preclinical Translational Study in Epilepsy

Esbjörn Melin, Avtandil Nanobashvili, Una Avdic, Casper R. Gøtzsche, My Andersson, David P.D. Woldbye & Merab Kokaia, 2019 dec 13, I: Molecular Therapy - Methods and Clinical Development. 15, s. 179-193 15 s.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Advancing research toward faster diagnosis, better treatment, and end of stigma in epilepsy

Asla Pitkänen, David C. Henshall, J. Helen Cross, Renzo Guerrini, Sergiusz Jozwiak, Merab Kokaia, Michele Simonato, Sanjay Sisodiya & Janet Mifsud, 2019, I: Epilepsia.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients

Jenny Wickham, Marco Ledri, Johan Bengzon, Bo Jespersen, Lars H. Pinborg, Elisabet Englund, David P.D. Woldbye, My Andersson & Merab Kokaia, 2019, I: Scientific Reports. 9, 1, 19393.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Leaky Optoelectrical Fiber for Optogenetic Stimulation and Electrochemical Detection of Dopamine Exocytosis from Human Dopaminergic Neurons

Shashank Vasudevan, Janko Kajtez, Ada Ioana Bunea, Ana Gonzalez-Ramos, Tania Ramos-Moreno, Arto Heiskanen, Merab Kokaia, Niels B. Larsen, Alberto Martínez-Serrano, Stephan S. Keller & Jenny Emnéus, 2019, I: Advanced Science. 6, 24, 1902011.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Long-Term, Targeted Delivery of GDNF from Encapsulated Cells Is Neuroprotective and Reduces Seizures in the Pilocarpine Model of Epilepsy

Giovanna Paolone, Chiara Falcicchia, Francesca Lovisari, Merab Kokaia, William J. Bell, Tracie Fradet, Mario Barbieri, Lars U. Wahlberg, Dwaine F. Emerich & Michele Simonato, 2019, I: The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 11, s. 2144-2156 13 s.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Unilateral ex vivo gene therapy by GDNF in epileptic rats

Avtandil Nanobashvili, Esbjörn Melin, Dwaine Emerich, Jens Tornøe, Michele Simonato, Lars Wahlberg & Merab Kokaia, 2019, I: Gene Therapy. 26, 3-4, s. 65-74

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Spatiotemporal pattern of Wnt-canonical pathway in dorsal telencephalic organoids.

Ana Gonzalez Ramos, Jonothon Marshall & John O. Mason, 2018 jul 6, (Unpublished).

Forskningsoutput: Konferensbidrag › Poster

Preserved function of afferent parvalbumin-positive perisomatic inhibitory synapses of dentate granule cells in rapidly kindled mice

Marita G. Hansen, Litsa N. Ledri, Deniz Kirik, Merab Kokaia & Marco Ledri, 2018 jan 9, I: Frontiers in Cellular Neuroscience. 11, 433.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Bridging the gap in translational epilepsy research - A patient brain tissue platform for validating animal data

Jenny Wickham, 2018, Lund: Lund University: Faculty of Medicine. 79 s.

Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

Altered chloride homeostasis decreases the action potential threshold and increases hyperexcitability in hippocampal neurons

Andreas T. Sørensen, Marco Ledri, Miriam Melis, Litsa Nikitidou Ledri, My Andersson & Merab Kokaia, 2017 nov 1, I: eNeuro. 4, 6, e0172-17.2017.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Epilepsy and optogenetics: Can seizures be controlled by light?

Jan Tönnesen & Merab Kokaia, 2017 jul 15, I: Clinical Science. 131, 14, s. 1605-1616 12 s.

Forskningsoutput: Tidskriftsbidrag › Översiktsartikel

DREADDs suppress seizure-like activity in a mouse model of pharmacoresistant epileptic brain tissue

N. Avaliani, M. Andersson, A. H. Runegaard, D. Woldbye & M. Kokaia, 2016 okt 1, I: Gene Therapy. 23, 10, s. 760-766 7 s.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Advances in the development of biomarkers for epilepsy

Asla Pitkänen, Wolfgang Löscher, Annamaria Vezzani, Albert J. Becker, Michele Simonato, Katarzyna Lukasiuk, Olli Gröhn, Jens P. Bankstahl, Alon Friedman, Eleonora Aronica, Jan A. Gorter, Teresa Ravizza, Sanjay M. Sisodiya, Merab Kokaia & Heinz Beck, 2016 jul 1, I: Lancet Neurology. 15, 8, s. 843-856 14 s.

Forskningsoutput: Tidskriftsbidrag › Översiktsartikel

Optogenetic control of human neurons in organotypic brain cultures

My Andersson, Natalia Avaliani, Andreas Svensson, Jenny Wickham, Lars H. Pinborg, Bo Jespersen, Søren H. Christiansen, Johan Bengzon, David P D Woldbye & Merab Kokaia, 2016 apr 21, I: Scientific Reports. 6, 24818.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Novel approaches to explore mechanisms of epileptic seizures - optogenetic and chemogenetic manipulation of hippocampal circuitry

Fredrik Berglind, 2016, Experimental Epilepsy Group. 71 s.

Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

Translational approach for gene therapy in epilepsy: Model system and unilateral overexpression of neuropeptide Y and Y2 receptors.

Litsa Nikitidou, Esbjörn Melin, Søren H Christiansen, Casper R Gøtzsche, Alessandra Cifra, David P D Woldbye & Merab Kokaia, 2016, I: Neurobiology of Disease. 86, nov 19, s. 52-61

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Chemogenetics, Induced Neurons and Pluripotent Stem Cells: Towards Advanced Gene and Cell Therapies Targeting Epilepsy

Natalia Avaliani, 2015, Department of Clinical Sciences, Lund University. 75 s.

Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

Differential Effect of Neuropeptides on Excitatory Synaptic Transmission in Human Epileptic Hippocampus.

Marco Ledri, Andreas T Sørensen, Marita Grönning Madsen, Søren H Christiansen, Litsa Nikitidou Ledri, Alessandra Cifra, Johan Bengzon, Eva Lindberg, Lars H Pinborg, Bo Jespersen, Casper R Gøtzsche, David P D Woldbye, My Andersson & Merab Kokaia, 2015, I: Journal of Neuroscience. 35, 26, s. 9622-9631

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

A compact multifunctional microfluidic platform for exploring cellular dynamics in real-time using electrochemical detection

K. Zor, A. Heiskanen, C. Caviglia, M. Vergani, E. Landini, F. Shah, M. Carminati, A. Martinez-Serrano, Tania Ramos Moreno, Merab Kokaia, D. Benayahu, Zs. Keresztes, D. Papkovsky, U. Wollenberger, W. E. Svendsen, M. Dimaki, G. Ferrari, R. Raiteri, M. Sampietro, M. Dufva & 1 andra, J. Emneus, 2014, I: RSC Advances. 4, 109, s. 63761-63771

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Global Optogenetic Activation of Inhibitory Interneurons during Epileptiform Activity.

Marco Ledri, Marita Grönning Madsen, Litsa Nikitidou, Deniz Kirik & Merab Kokaia, 2014, I: Journal of Neuroscience. 34, 9, s. 3364-3377

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

How Might Novel Technologies Such as Optogenetics Lead to Better Treatments in Epilepsy?

Esther Krook-Magnuson, Marco Ledri, Ivan Soltesz & Merab Kokaia, 2014, Issues in Clinical Epileptology: A View From the Bench. Scharfman, H. E. & Buckmaster, P. S. (red.). Springer, Vol. 813. s. 319-336 (Advances in Experimental Medicine and Biology; vol. 813).

Forskningsoutput: Kapitel i bok/rapport/Conference proceeding › Kapitel samlingsverk

Optogenetic inhibition of chemically induced hypersynchronized bursting in mice.

Fredrik Berglind, Marco Ledri, Andreas Toft Sørensen, Litsa Nikitidou, Miriam Melis, Pascal Bielefeld, Deniz Kirik, Karl Deisseroth, My Andersson & Merab Kokaia, 2014, I: Neurobiology of Disease. 65, s. 133-141

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Optogenetics reveal delayed afferent synaptogenesis on grafted human induced pluripotent stem cell-derived neural progenitors.

Natalia Avaliani, Andreas Toft Sörensen, Marco Ledri, Johan Bengzon, Philipp Koch, Oliver Brüstle, Karl Deisseroth, My Andersson & Merab Kokaia, 2014, I: Stem Cells. 32, 12, s. 3088-3098

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Quantitative mapping of the local and extrinsic sources of GABA and Reelin to the layer Ia neuropil in the adult rat neocortex

Tania Ramos Moreno & Francisco Clasca, 2014, I: Brain Structure and Function. 219, 5, s. 1639-1657

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Epilepsy therapy development: Technical and methodologic issues in studies with animal models

Aristea S. Galanopoulou, Merab Kokaia, Jeffrey A. Loeb, Astrid Nehlig, Asla Pitkanen, Michael A. Rogawski, Kevin J. Staley, Vicky H. Whittemore & F. Edward Dudek, 2013, I: Epilepsia. 54, s. 13-23

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Altered profile of basket cell afferent synapses in hyper-excitable dentate gyrus revealed by optogenetic and two-pathway stimulations.

Marco Ledri, Litsa Nikitidou, Ferenc Erdelyi, Gabor Szabo, Deniz Kirik, Karl Deisseroth & Merab Kokaia, 2012, I: European Journal of Neuroscience. 36, 1, s. 1971-1983

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures

Casper R. Gotzsche, Litsa Nikitidou, Andreas Toft Sörensen, Mikkel V. Olesen, Gunnar Sorensen, Soren H. O. Christiansen, Mikael Ängehagen, David P. D. Woldbye & Merab Kokaia, 2012, I: Neurobiology of Disease. 45, 1, s. 288-296

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

VEGF receptor-2 (flk-1) overexpression in mice counteracts focal epileptic seizures.

Litsa Nikitidou, Irene Kanter Schlifke, Joke Dhondt, Peter Carmeliet, Diether Lambrechts & Merab Kokaia, 2012, I: PLoS ONE. 7, 7, e40535.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Functional integration of grafted neural stem cell-derived dopaminergic neurons monitored by optogenetics in an in vitro Parkinson model.

Jan Tønnesen, Clare L Parish, Andreas Toft Sörensen, Angelica Andersson, Cecilia Lundberg, Karl Deisseroth, Ernest Arenas, Olle Lindvall & Merab Kokaia, 2011, I: PLoS ONE. 6, 3, e17560.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Tuning afferent synapses of hippocampal interneurons by neuropeptide Y.

Marco Ledri, Andreas Toft Sörensen, Ferenc Erdelyi, Gabor Szabo & Merab Kokaia, 2011, I: Hippocampus. 21, s. 198-211

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures.

David P D Woldbye, Mikael Ängehagen, Casper R Gøtzsche, Heidi Elbrønd-Bek, Andreas Toft Sörensen, Søren H Christiansen, Mikkel V Olesen, Litsa Nikitidou, Thomas V O Hansen, Irene Kanter Schlifke & Merab Kokaia, 2010, I: Brain. 133, Pt 9, s. 2778-2788

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

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