Proteomisk hematologi

Organisation: forskargrupp

Forskningsområden

Ämnesklassifikation (UKÄ)

  • Cancer och onkologi

Nyckelord

  • Hematopoiesis, stamcell, leukemi, proteomik, mass-spektrometri

Beskrivning

Forskning

Proteins are the machinery of the cell, responsible for executing the functions essential for cells to operate, survive, differentiate and divide. In hematopoiesis, the proteomic make-up of blood stem cells and progenitors can regulate their cell fate and susceptibility to initiation as well as progression of leukemia. The broad interest of our group lies in understanding the molecular differences between fetal and adult hematopoiesis. By using in-depth mass spectrometry-based quantitative proteomics to monitor protein levels in a comprehensive and quantitative manner, our ongoing research aims at defining the fetal- and adult-specific proteomic programs that regulate normal and malignant hematopoiesis. Future work will include detailed proteomic profiling of ontogeny-specific leukemic features, investigation of the mechanistic details of hematopoietic stem cell plasticity, as well as specific types of post-translational modifications of particular importance in early hematopoiesis.

Senaste forskningsoutput

Carolin A. Kolmeder & Willem M. de Vos, 2021, I: Journal of Pharmaceutical and Biomedical Analysis. 194, 113751.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Simon Raffel, Daniel Klimmeck, Mattia Falcone, Aykut Demir, Alireza Pouya, Petra Zeisberger, Cristoph Lutz, Marco Tinelli, Oliver Bischel, Lars Bullinger, Christian Thiede, Anne Flörcken, Gerhard Ehninger, Anthony Ho, Carsten Müller-Tidow, Zuguang Gu, Carl Hermann, Jeroen Krijgsveld, Andreas Trumpp & Jenny Hansson, 2020 sep 24, I: Blood. 136, 13, s. 1507-1519 13 s.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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