Respiratorisk immunofarmakologi
Organisation: forskargrupp
- Översiktsartikel
Research highlights from the 2018 European Respiratory Society International Congress: airway disease
Schleich, F., Bikov, A., Mathioudakis, A. G., McDonnell, M., Cecilia Andersson, Bonini, M., Lena Uller, Idzko, M., Singh, D., Lopez-Campos, J. L., Bossios, A., Adcock, I. M., Usmani, O., Spanevello, A. & Bonvini, S. J., 2019 feb, I : ERJ Open Research. 5, 1, 11 s.Forskningsoutput: Tidskriftsbidrag › Översiktsartikel
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Translational value of animal models of asthma: Challenges and promises.
Sagar, S., Hamid Akbarshahi & Lena Uller, 2015, I : European Journal of Pharmacology. 759, Mar 28, s. 272-277Forskningsoutput: Tidskriftsbidrag › Översiktsartikel
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Resolution of leucocyte-mediated mucosal diseases. A novel in vivo paradigm for drug development
Carl Persson & Lena Uller, 2012, I : British Journal of Pharmacology. 165, 7, s. 2100-2109Forskningsoutput: Tidskriftsbidrag › Översiktsartikel
Resolution of cell-mediated airways diseases
Carl Persson & Lena Uller, 2010, I : Respiratory Research. 11Forskningsoutput: Tidskriftsbidrag › Översiktsartikel
- Doktorsavhandling (sammanläggning)
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On causes and regulation of anti-viral defence in asthma and COPD
Mandy Menzel, 2018, Lund: Lund University: Faculty of Medicine. 76 s.Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)
Translational studies of viral-induced asthma and COPD exacerbations
Irma Mahmutovic Persson, 2016, Lund: Lund University: Faculty of Medicine. 122 s.Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)
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Emerging role of RIG-I-like receptors in antiviral innate immunity in airway structural cells
Calvén, J., 2015, Department of Experimental Medical Science, Lund Univeristy. 94 s.Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)
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Targeting viral induced TSLP - an airway treatment opportunity
Brandelius, A., 2014, Respiratory Immunopharmacology. 82 s.Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)
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Development and Resolution of Allergic Airway Inflammation in vivo: effects of therapeutic intervention
Lena Uller, 2005, Department of Experimental Medical Science, Lund Univeristy.Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)
- Debate/Note/Editorial
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Viral induced overproduction of epithelial TSLP: Role in exacerbations of asthma and COPD?
Lena Uller & Carl Persson, 2018 aug 1, I : Journal of Allergy and Clinical Immunology. 142, 2, s. 712 1 s.Forskningsoutput: Tidskriftsbidrag › Debate/Note/Editorial
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Epithelial perviousness in allergic airways disease
Carl Persson & Lena Uller, 2017, I : Journal of Allergy and Clinical Immunology. 140, 4, s. 1211Forskningsoutput: Tidskriftsbidrag › Debate/Note/Editorial
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'To measure is to know' (Lord Kelvin)
Ward, C. & Lena Uller, 2015, I : Respirology. 20, 1, s. 9-10Forskningsoutput: Tidskriftsbidrag › Debate/Note/Editorial
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Roles of plasma exudation in asthma and COPD
Carl Persson & Lena Uller, 2009, I : Clinical and Experimental Allergy. 39, 11, s. 1626-1629Forskningsoutput: Tidskriftsbidrag › Debate/Note/Editorial
- Letter
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Reduced granulocyte counts in sputum may reflect aggravated disease.
Carl Persson & Lena Uller, 2015, I : Journal of Allergy and Clinical Immunology. 135, 3, s. 836-836Forskningsoutput: Tidskriftsbidrag › Letter
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Glucocorticoids induce the production of the chemoattractant CCL20 in airway epithelium.
Carl Persson & Lena Uller, 2015, I : European Respiratory Journal. 45, 3, s. 859-860Forskningsoutput: Tidskriftsbidrag › Letter
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Importance of concomitant local and systemic eosinophilia in uncontrolled asthma.
Carl Persson & Lena Uller, 2014, I : European Respiratory Journal. 44, 4, s. 1096-1098Forskningsoutput: Tidskriftsbidrag › Letter
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Interferon regulatory factor 3 activation mediates viral stimulus-induced bronchial production of thymic stromal lymphopoietin.
Lena Uller, 2013, I : Journal of Allergy and Clinical Immunology. 131, 3, s. 926-926Forskningsoutput: Tidskriftsbidrag › Letter
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Simvastatin-induced effects on bronchial epithelial cells from COPD donors.
Lena Uller, 2013, I : European Respiratory Journal. 41, 6, s. 1464-1465Forskningsoutput: Tidskriftsbidrag › Letter
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Primary lysis of eosinophils as a major mode of activation of eosinophils in human diseased tissues.
Carl Persson & Lena Uller, 2013, I : Nature Reviews. Immunology. 13, 12, s. 902Forskningsoutput: Tidskriftsbidrag › Letter
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Increased lung neutrophil apoptosis and inflammation resolution
Carl Persson & Lena Uller, 2012, I : European Respiratory Journal. 39, 3, s. 789-790Forskningsoutput: Tidskriftsbidrag › Letter
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Letter to Respiratory Medicine: "Drugs reducing transepithelial leukocyte traffic may worsen lung disease"
Carl Persson & Lena Uller, 2011, I : Respiratory Medicine. 105, s. 1969-1969Forskningsoutput: Tidskriftsbidrag › Letter
- Artikel i vetenskaplig tidskrift
Rhinovirus-induced IFNβ expression is NFκB-dependent and regulated by the macrophage microenvironment
Mandy Menzel, Kosinski, J., Lena Uller & Hamid Akbarshahi, 2019 sep 16, I : Scientific Reports. 9, 1, 13394.Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
Distal respiratory tract viral infections in young children trigger a marked increase in alveolar mast cells
Cecilia K Andersson, Shikhagaie, M., Mori, M., Al-Garawi, A., Reed, J. L., Humbles, A. A., Welliver, R., Mauad, T., Leif Bjermer, Jordana, M. & Jonas S Erjefält, 2018 okt, I : ERJ Open Research. 4, 4Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
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Uncontrolled asthmatics have increased FceRI+ and TGF-β–positive MCTC mast cells and collagen VI in the alveolar parenchyma
C. K. Andersson, M. Weitoft, K. Rydell-Törmänen, L. Bjermer, G. Westergren-Thorsson & J. S. Erjefält, 2018 mar 1, I : Clinical and Experimental Allergy. 48, 3, s. 266-277 12 s.Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
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Allergens produce serine proteases-dependent distinct release of metabolite DAMPs in human bronchial epithelial cells
Sangeetha Ramu, Mandy Menzel, Leif Bjermer, Cecilia Andersson, Hamid Akbarshahi & Lena Uller, 2018, I : Clinical and Experimental Allergy. 48, 2, s. 156-166Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
IL-1β mediates lung neutrophilia and IL-33 expression in a mouse model of viral-induced asthma exacerbation
Irma Mahmutovic Persson, Mandy Menzel, Sangeetha Ramu, Samuel Cerps, Hamid Akbarshahi & Lena Uller, 2018, I : Respiratory Research. 19, 1, 16.Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
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House dust mite impairs antiviral response in asthma exacerbation models through its effects on TLR3
Hamid Akbarshahi, Mandy Menzel, Sangeetha Ramu, Irma Mahmutovic Persson, Leif Bjermer & Lena Uller, 2018, I : Allergy. 73, 5, s. 1053-1063Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation
Mandy Menzel, Hamid Akbarshahi, Ellen Tufvesson, Carl Persson, Leif Bjermer & Lena Uller, 2017, I : Oncotarget. 8, 19, s. 31601-31611 11 s.Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
A Randomized, Double-Blind, Placebo-Controlled Pilot Clinical Study on ColdZyme® Mouth Spray against Rhinovirus-Induced Common Cold
Clarsund, M., Fornbacke, M., Lena Uller, Johnston, S. L. & Emanuelsson, C. A., 2017, I : Open Journal of Respiratory Diseases. 7, 4, s. 125-135Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
Azithromycin induces anti-viral effects in cultured bronchial epithelial cells from COPD patients
Mandy Menzel, Hamid Akbarshahi, Leif Bjermer & Lena Uller, 2016 jun 28, I : Scientific Reports. 6, 28698.Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation.
Irma Mahmutovic Persson, Hamid Akbarshahi, Mandy Menzel, Brandelius, A. & Lena Uller, 2016, I : Journal of Translational Medicine. 14, 1, 52.Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
Inbreeding affects gene expression differently in two self-incompatible Arabidopsis lyrata populations with similar levels of inbreeding depression.
Mandy Menzel, Sletvold, N., Ågren, J. & Bengt Hansson, 2015, I : Molecular biology and evolution. 32, 8, s. 2036-2047Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
Rhinoviral stimuli, epithelial factors and ATP signalling contribute to bronchial smooth muscle production of IL-33
Calvén, J., Hamid Akbarshahi, Mandy Menzel, Ayata, C. K., Idzko, M., Leif Bjermer & Lena Uller, 2015, I : Journal of Translational Medicine. 13, 281.Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
Early Activation of Pulmonary TGF- β 1/Smad2 Signaling in Mice with Acute Pancreatitis-Associated Acute Lung Injury.
Hamid Akbarshahi, Sam, A., Chen, C., Ann Rosendahl & Roland Andersson, 2014, I : Mediators of Inflammation. 2014, Feb 12, 148029.Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
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Topical dsRNA challenges may induce overexpression of airway antiviral cytokines in symptomatic allergic disease. A pilot in vivo study in nasal airways.
Brandelius, A., Morgan Andersson & Lena Uller, 2014, I : Respiratory Medicine. 108, 12, s. 1816-1819Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
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HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase.
Evenäs, J., Edfeldt, F., Lepistö, M., Svitacheva, N., Synnergren, A., Lundquist, B., Gränse, M., Anna Rönnholm, Varga, M., Wright, J., Wei, M., Yue, S., Wang, J., Li, C., Li, X., Chen, G., Liao, Y., Lv, G., Tjörnebo, A. & Narjes, F., 2014, I : Bioorganic & Medicinal Chemistry Letters. 24, 5, s. 1315-1321Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma.
Irma Mahmutovic Persson, Hamid Akbarshahi, Bartlett, N. W., Glanville, N., Johnston, S. L., Brandelius, A. & Lena Uller, 2014, I : Allergy. 69, 3, s. 348-358Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
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TRPV4-mediated calcium influx and ciliary activity in human native airway epithelial cells.
Lisa Alenmyr, Lena Uller, Greiff, L., Högestätt, E. & Peter Zygmunt, 2014, I : Basic & Clinical Pharmacology & Toxicology. 114, 2, s. 210-216Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
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'Theirs but to die and do' - Primary lysis of eosinophils and free eosinophil granules (FEGs) in asthma.
Carl Persson & Lena Uller, 2014, I : American Journal of Respiratory and Critical Care Medicine. 189, 6, s. 628-633Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
Reduced expression of the polymeric immunoglobulin receptor in pancreatic and periampullary adenocarcinoma signifies tumour progression and poor prognosis
Richard Fristedt, Jacob Elebro, Gaber, A., Ben Dror, L., Margareta Heby, Yudina, Y., Björn Nodin, Uhlén, M., Jakob Eberhard & Karin Jirström, 2014, I : PLoS ONE. 9, 11, s. e112728 e112728.Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
Rhinovirus and dsRNA Induce RIG-I-Like Receptors and Expression of Interferon β and λ1 in Human Bronchial Smooth Muscle Cells.
Calvén, J., Yudina, Y. & Lena Uller, 2013, I : PLoS ONE. 8, 4, e62718.Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
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Capacity of capsazepinoids to relax human small airways and inhibit TLR3-induced TSLP and IFNβ production in diseased bronchial epithelial cells.
Irma Mahmutovic Persson, Johansson, M., Brandelius, A., Calvén, J., Leif Bjermer, Yudina, Y. & Lena Uller, 2012, I : International Immunopharmacology. 13, 3, s. 292-300Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
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Viral Stimuli Trigger Exaggerated Thymic Stromal Lymphopoietin Expression by Chronic Obstructive Pulmonary Disease Epithelium: Role of Endosomal TLR3 and Cytosolic RIG-I-Like Helicases.
Calvén, J., Yudina, Y., Oskar Hallgren, Gunilla Westergren-Thorsson, Davies, D. E., Brandelius, A. & Lena Uller, 2012, I : Journal of Innate Immunity. 4, s. 86-99Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
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Effects of the cyclin-dependent kinase inhibitor R-roscovitine on eosinophil survival and clearance.
Farahi, N., Lena Uller, Juss, J. K., Langton, A. J., Cowburn, A. S., Gibson, A., Foster, M. R., Farrow, S. N., Marco-Casanova, P., Sobolewski, A., Condliffe, A. M. & Chilvers, E. R., 2011, I : Clinical and Experimental Allergy. 41, 5, s. 673-687Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
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Increased fecal leukocytes may reflect resolution of IBD.
Carl Persson & Lena Uller, 2011, I : Scandinavian Journal of Gastroenterology. 46, s. 251-252Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
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dsRNA-induced expression of thymic stromal lymphopoietin (TSLP) in asthmatic epithelial cells is inhibited by a small airway relaxant.
Brandelius, A., Yudina, Y., Calvén, J., Leif Bjermer, Morgan Andersson, Carl Persson & Lena Uller, 2011, I : Pulmonary Pharmacology & Therapeutics. 24, s. 59-66Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
Early phase resolution of mucosal eosinophilic inflammation in allergic rhinitis.
Lena Uller, Ahlström-Emanuelsson, C., Morgan Andersson, Jonas Erjefält, Greiff, L. & Carl Persson, 2010, I : Respiratory Research. 11, 1, 54.Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
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Transepithelial exit of leucocytes: inflicting, reflecting or resolving airway inflammation?
Carl Persson & Lena Uller, 2010, I : Thorax. 65, s. 1111-1115Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation.
Lena Uller, Mathiesen, J. M., Lisa Alenmyr, Korsgren, M., Ulven, T., Hogberg, T., Andersson, G., Carl Persson & Kostenis, E., 2007, I : Respiratory Research. 8:16Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
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Effects of steroid treatment on lung CC chemokines, apoptosis and transepithelial cell clearance during development and resolution of allergic airway inflammation.
Lena Uller, Lloyd, C. M., Kristina Rydell-Törmänen, Carl Persson & Jonas Erjefält, 2006, I : Clinical and Experimental Allergy. 36, 1, s. 111-121Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
Anti-Fas mAb-induced apoptosis and cytolysis of airway tissue eosinophils aggravates rather than resolves established inflammation.
Lena Uller, Kristina Rydell-Törmänen, Carl Persson & Jonas Erjefält, 2005, I : Respiratory Research. 6:90Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
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Blockade of ctla-4 promotes airway inflammation in naive mice exposed to aerosolized allergen but fails to prevent inhalation tolerance.
Lisa Alenmyr, Matheu, V., Lena Uller, Greiff, L., Malm-Erjefält, M., Ljunggren, H-G., Carl Persson & Korsgren, M., 2005, I : Scandinavian Journal of Immunology. 62, 5, s. 437-444Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
Role of macrophage migration inhibitory factor (MIF) in allergic and endotoxin-induced airway inflammation in mice
Korsgren, M., Kallstrom, L., Lena Uller, Bjerke, T., Sundler, F., Carl Persson & Korsgren, O., 2000, I : Mediators of Inflammation. 9, 1, s. 15-23Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift