Marco Ledri

Forskare, Biträdande, Doktor, MSc, BSc

Forskningsområden

Ämnesklassifikation (UKÄ)

  • Neurovetenskaper
  • Klinisk medicin

Nyckelord

  • epilepsi, CRISPR/Cas9, epileptogenesis, Genterapi

Forskning

Epilepsy is a devastating neurological disorder characterized by incontrollable synchronous neuronal activity, which clinically manifests as epileptic seizures. Epilepsy usually develops after an initial insult, such as head trauma or stroke, which trigger the epileptogenic process. During epileptogenesis, the affected brain regions undergo multiple changes in connectivity and gene expression, and between the most affected genes are those responsible for network inhibition. These include genes coding for GABA and endocannabinoid receptors, which are usually downregulated during epileptogenesis, opening up the possibility of interfering with their expression by gene therapy approaches to block the development of recurrent seizures. Recent developments in gene editing technologies, after the discovery and application of the bacteria-derived CRISPR-Cas9 system, have opened new avenues for gene therapy. In particular, the possibility of developing a reversible and precise regulatory system for endogenous genes with high spatio-temporal control, overcomes several limitations of the classic gene therapy approaches. Our group's current research aims to develop and apply an on-demand, controllable gene expression technology, based on guide RNAs and a catalytically inactive Cas9, targeting the expression of GABA and CB1 receptors for the control of epileptogenesis. 

Utvald forskningsoutput

Sørensen, A. T., Marco Ledri, Melis, M., Ledri, L. N., My Andersson & Merab Kokaia, 2017 nov 1, I : eNeuro. 4, 6, e0172-17.2017.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Tönnesen, J., Marco Ledri & Merab Kokaia, 2017, Optogenetics: From Neuronal Function to Mapping and Disease Biology. Appasani, K. (red.). Cambridge: Cambridge University Press, s. 292-307

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKapitel samlingsverk

Dudok, B., Barna, L., Ledri, M., Szabó, S. I., Szabadits, E., Pintér, B., Woodhams, S. G., Henstridge, C. M., Balla, G. Y., Nyilas, R., Varga, C., Lee, S-H., Matolcsi, M., Cervenak, J., Kacskovics, I., Watanabe, M., Sagheddu, C., Melis, M., Pistis, M., Soltesz, I. & 1 andraKatona, I., 2015 jan, I : Nature Neuroscience. 18, 1, s. 75-86 12 s.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Marco Ledri, Sørensen, A. T., Grönning Madsen, M., Christiansen, S. H., Ledri, L. N., Cifra, A., Johan Bengzon, Lindberg, E., Pinborg, L. H., Jespersen, B., Gøtzsche, C. R., Woldbye, D. P. D., My Andersson & Merab Kokaia, 2015, I : Journal of Neuroscience. 35, 26, s. 9622-9631

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Marco Ledri, Grönning Madsen, M., Nikitidou, L., Deniz Kirik & Merab Kokaia, 2014, I : Journal of Neuroscience. 34, 9, s. 3364-3377

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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