Tomas Björklund

Universitetslektor, Docent, Doktor i Medicinsk Vetenskap
Fler filtreringsmöjligheter
  1. 2019
  2. Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson's disease

    Carl Rosenblad, Li, Q., Pioli, E. Y., Dovero, S., Antunes, A. S. L. M., Agúndez, L., Bardelli, M., Linden, R. M., Henckaerts, E., Anders Björklund, Bezard, E. & Tomas Björklund, 2019, I : Brain : a journal of neurology. s. 2402-2416

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  3. 2018
  4. A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency

    Tordo, J., O'Leary, C., Antunes, A. S. L. M., Palomar, N., Aldrin-Kirk, P., Basche, M., Bennett, A., D'Souza, Z., Gleitz, H., Godwin, A., Holley, R. J., Parker, H., Liao, A. Y., Rouse, P., Youshani, A. S., Dridi, L., Martins, C., Levade, T., Stacey, K. B., Davis, D. M. & 11 andraDyer, A., Clément, N., Tomas Björklund, Ali, R. R., Agbandje-McKenna, M., Rahim, A. A., Pshezhetsky, A., Waddington, S. N., Linden, R. M., Bigger, B. W. & Henckaerts, E., 2018 jul 1, I : Brain. 141, 7, s. 2014-2031 18 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  5. Molecular barcoding of viral vectors enables mapping and optimization of mRNA trans-splicing

    Marcus Davidsson, Díaz-Fernández, P., Torroba, M., Schwich, O. D., Aldrin-Kirk, P., Luis Quintino, Andreas Heuer, Wang, G., Cecilia Lundberg & Tomas Björklund, 2018 maj 1, I : RNA. 24, 5, s. 673-687 15 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  6. Chemogenetic modulation of cholinergic interneurons reveals their regulating role on the direct and indirect output pathways from the striatum

    Aldrin-Kirk, P., Andreas Heuer, Rylander Ottosson, D., Marcus Davidsson, Mattsson, B. & Tomas Björklund, 2018 jan, I : Neurobiology of Disease. 109, s. 148-162

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  7. Repairing the brain: Gene therapy

    Tomas Björklund, 2018, I : Journal of Parkinson's Disease. 8, s1, s. S123-S130

    Forskningsoutput: TidskriftsbidragÖversiktsartikel

  8. 2016
  9. A novel process of viral vector barcoding and library preparation enables high-diversity library generation and recombination-free paired-end sequencing

    Marcus Davidsson, Diaz-Fernandez, P., Schwich, O. D., Torroba, M., Wang, G. & Tomas Björklund, 2016 nov 22, I : Scientific Reports. 6, 37563.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  10. Identification of multiple QTLs linked to neuropathology in the engrailed-1 heterozygous mouse model of Parkinson's disease

    Kurowska, Z., Jewett, M., Brattås, P. L., Itzia Jimenez, Kenéz, X., Tomas Björklund, Nordström, U., Brundin, P. & Maria Swanberg, 2016 aug 23, I : Scientific Reports. 6, 31701.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  11. DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor

    Aldrin-Kirk, P., Andreas Heuer, Wang, G., Mattsson, B., Lundblad, M., Malin Parmar & Tomas Björklund, 2016 jun 1, I : Neuron. 90, 5, s. 955-968 14 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  12. Expression of Multiple Functional RNAs or Proteins from One Viral Vector.

    Tomas Björklund, 2016, I : Methods in Molecular Biology. 1382, s. 41-56

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  13. 2014
  14. Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.

    Holmqvist, S., Chutna, O., Bousset, L., Aldrin-Kirk, P., Wen Li, Tomas Björklund, Wang, Z-Y., Laurent Roybon, Melki, R. & Jia-Yi Li, 2014, I : Acta Neuropathologica. 128, 6, s. 805-820

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  15. Novel AAV-Based Rat Model of Forebrain Synucleinopathy Shows Extensive Pathologies and Progressive Loss of Cholinergic Interneurons.

    Aldrin-Kirk, P., Marcus Davidsson, Holmqvist, S., Jia-Yi Li & Tomas Björklund, 2014, I : PLoS ONE. 9, 7, e100869.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  16. 2013
  17. A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP.

    Christian Hansen, Tomas Björklund, Petit, G., Lundblad, M., Murmu, R., Brundin, P. & Jia-Yi Li, 2013, I : Neurobiology of Disease. 56C, April,30, s. 145-155

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  18. Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease.

    Cederfjäll, E., Nilsson, N., Gurdal Sahin, Chu, Y., Nikitidou, E., Tomas Björklund, Kordower, J. H. & Deniz Kirik, 2013, I : Scientific Reports. 3, 2157.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  19. 2012
  20. Dysregulated dopamine storage increases the vulnerability to alpha-synuclein in nigral neurons

    Ulusoy, A., Tomas Björklund, Buck, K. & Deniz Kirik, 2012, I : Neurobiology of Disease. 47, 3, s. 367-377

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  21. 2011
  22. Gene therapy for Parkinson's disease shows promise.

    Anders Björklund & Tomas Björklund, 2011, I : Science Translational Medicine. 3, 79, s. 79ed1

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  23. Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.

    Hult Lundh, S., Rana Soylu, Tomas Björklund, Belgardt, B. F., Mauer, J., Brüning, J. C., Deniz Kirik & Åsa Petersén, 2011, I : Cell Metabolism. 13, 4, s. 428-439

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  24. 2010
  25. A General Chemical Method to Regulate Protein Stability in the Mammalian Central Nervous System

    Iwamoto, M., Tomas Björklund, Cecilia Lundberg, Deniz Kirik & Wandless, T. J., 2010, I : Chemistry and Biology. 17, 9, s. 981-988

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  26. Differential Transduction Following Basal Ganglia Administration of Distinct Pseudotyped AAV Capsid Serotypes in Nonhuman Primates

    Dodiya, H. B., Tomas Björklund, Stansell, J. III., Mandel, R. J., Deniz Kirik & Kordower, J. H., 2010, I : Molecular Therapy. 18, 3, s. 579-587

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  27. Gene therapy for dopamine replacement.

    Tomas Björklund, Cederfjäll, E. & Deniz Kirik, 2010, I : Progress in Brain Research. 184, s. 221-235

    Forskningsoutput: TidskriftsbidragÖversiktsartikel

  28. Gene therapy for Parkinson's disease.

    Tomas Björklund & Kordower, J. H., 2010, I : Movement Disorders. 25 Suppl 1, s. S161-S173

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  29. Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson's disease.

    Tomas Björklund, Carlsson, T., Cederfjäll, E., Carta, M. & Deniz Kirik, 2010, I : Brain. 133, Pt 2, s. 496-511

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  30. 2009
  31. Dose Optimization for Long-term rAAV-mediated RNA Interference in the Nigrostriatal Projection Neurons.

    Ulusoy, A., Gurdal Sahin, Tomas Björklund, Aebischer, P. & Deniz Kirik, 2009, I : Molecular Therapy. 17, s. 1574-1584

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  32. Gene therapy for dopamine replacement in Parkinson's disease.

    Anders Björklund, Tomas Björklund & Deniz Kirik, 2009, I : Science Translational Medicine. 1, 2, s. 2ps2

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  33. Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats

    Tomas Björklund, Hall, H., Breysse, N., Soneson, C., Carlsson, T., Mandel, R. J., Carta, M. & Deniz Kirik, 2009, I : Journal of Neurochemistry. 111, 2, s. 355-367

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  34. Positron Emission Tomography Imaging Demonstrates Correlation between Behavioral Recovery and Correction of Dopamine Neurotransmission after Gene Therapy

    Leriche, L., Tomas Björklund, Breysse, N., Besret, L., Gregoire, M-C., Carlsson, T., Dolle, F., Mandel, R. J., Deglon, N., Hantraye, P. & Deniz Kirik, 2009, I : Journal of Neuroscience. 29, 5, s. 1544-1553

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  35. 2008
  36. Applications of lentiviral vectors for biology and gene therapy of neurological disorders.

    Cecilia Lundberg, Tomas Björklund, Carlsson, T., Johan Jakobsson, Hantraye, P., Déglon, N. & Deniz Kirik, 2008, I : Current Gene Therapy. 8, 6, s. 461-473

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  37. Future Cell- and Gene-Based Therapies for Parkinson's Disease

    Tomas Björklund, Morizane, A., Deniz Kirik & Brundin, P., 2008, Therapeutics of Parkinson's Disease and Other Movement Disorders. Hallett, M. & Poewe, P. (red.). John Wiley & Sons, s. 145-156

    Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKapitel samlingsverk

  38. In vivo gene delivery for development of mammalian models for Parkinson's disease

    Ulusoy, A., Tomas Björklund, Hermening, S. & Deniz Kirik, 2008, I : Experimental Neurology. 209, 1, s. 89-100

    Forskningsoutput: TidskriftsbidragÖversiktsartikel

  39. 2007
  40. Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain.

    Eslamboli, A., Romero-Ramos, M., Burger, C., Tomas Björklund, Muzyczka, N., Mandel, R. J., Baker, H., Ridley, R. M. & Deniz Kirik, 2007, I : Brain. 130, 3, s. 799-815

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  41. 2006
  42. Morphometric and psychometric comparisons between non-substance-abusing patients with posttraumatic stress disorder and normal controls

    Emdad, R., Bonekamp, D., Sondergaard, H. P., Tomas Björklund, Agartz, I., Ingvar, M. & Theorell, T., 2006, I : Psychotherapy and Psychosomatics. 75, 2, s. 122-132

    Forskningsoutput: TidskriftsbidragLetter

  43. 2005
  44. Imaging in cell-based therapy for neurodegenerative diseases.

    Deniz Kirik, Breysse, N., Tomas Björklund, Besret, L. & Hantraye, P., 2005, I : European Journal of Nuclear Medicine and Molecular Imaging. 32, Suppl 2, s. S417-S434

    Forskningsoutput: TidskriftsbidragÖversiktsartikel