Ulf Nilsson

Professor
Fler filtreringsmöjligheter
  1. 2020
  2. Synthesis of tricyclic carbohydrate-benzene hybrids as selective inhibitors of galectin-1 and galectin-8 N-terminal domains

    Wu, C., Yong, C., Zhong, Q., Wang, Z., Ulf J. Nilsson & Zhang, Y., 2020 maj 22, I : RSC Advances. 10, 33, s. 19636-19642 7 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  3. Epimers Switch Galectin-9 Domain Selectivity: 3 N-Aryl Galactosides Bind the C-Terminal and Gulosides Bind the N-Terminal

    Mukul Mahanti, Pal, K. B., Sundin, A. P., Hakon Leffler & Ulf J. Nilsson, 2020, I : ACS Medicinal Chemistry Letters. 11, 1, s. 34-39

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  4. 2019
  5. 3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-Sites for High-Affinity and High-Selectivity Inhibition of Galectin-3

    Alexander Dahlqvist, Mandal, S., Peterson, K., Håkansson, M., Derek T. Logan, Zetterberg, F. R., Hakon Leffler & Ulf J. Nilsson, 2019 dec 12, I : Molecules. 24, 24, 4554.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  6. Extracellular and intracellular small-molecule galectin-3 inhibitors

    John Stegmayr, Zetterberg, F., Carlsson, M. C., Huang, X., Sharma, G., Kahl-Knutson, B., Schambye, H., Ulf J. Nilsson, Stina Oredsson & Hakon Leffler, 2019 feb 18, I : Scientific Reports. 9, 1, 2186.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  7. Human trophoblast requires galectin-3 for cell migration and invasion

    Bojić-Trbojević, Jovanović Krivokuća, M., Vilotić, A., Kolundžić, N., Stefanoska, I., Zetterberg, F., U. J. Nilsson, H. Leffler & Vićovac, L., 2019 feb 14, I : Scientific Reports. 9, 1, 2136.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  8. Aminopyrimidine-galactose hybrids are highly selective galectin-3 inhibitors

    Alexander Dahlqvist, Zetterberg, F. R., Hakon Leffler & Ulf J. Nilsson, 2019, I : MedChemComm. 10, 6, s. 913-925 13 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  9. An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade

    Vuong, L., Kouverianou, E., Rooney, C. M., McHugh, B. J., Howie, S. E. M., Gregory, C. D., Forbes, S. J., Henderson, N. C., Zetterberg, F. R., Ulf J. Nilsson, Hakon Leffler, Ford, P., Pedersen, A., Gravelle, L., Tantawi, S., Schambye, H., Sethi, T. & MacKinnon, A. C., 2019, I : Cancer Research. 79, 7, s. 1480-1492 13 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  10. Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease

    Boza-Serrano, A., Ruiz, R., Sanchez-Varo, R., García-Revilla, J., Yang, Y., Jimenez-Ferrer, I., Paulus, A., Wennström, M., Vilalta, A., Allendorf, D., Davila, J. C., Stegmayr, J., Jiménez, S., Roca-Ceballos, M. A., Navarro-Garrido, V., Swanberg, M., Hsieh, C. L., Real, L. M., Englund, E., Linse, S. & 7 andra, Hakon Leffler, Ulf J. Nilsson, Brown, G. C., Gutierrez, A., Vitorica, J., Venero, J. L. & Tomas Deierborg, 2019, I : Acta Neuropathologica. 138, 2, s. 251-273

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  11. Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding

    Verteramo, M. L., Olof Stenström, Majda Misini Ignjatović, Octav Caldararu, Olsson, M. A., Manzoni, F., Hakon Leffler, Oksanen, E., Derek T. Logan, Ulf J. Nilsson, Ulf Ryde & Mikael Akke, 2019, I : Journal of the American Chemical Society. 141, 5, s. 2012–2026

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  12. 2018
  13. Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site

    Wahlgren, W. Y., Dunevall, E., North, R. A., Paz, A., Scalise, M., Bisignano, P., Bengtsson-Palme, J., Goyal, P., Claesson, E., Caing-Carlsson, R., Andersson, R., Beis, K., Nilsson, U. J., Farewell, A., Pochini, L., Indiveri, C., Grabe, M., Dobson, R. C. J., Abramson, J., Ramaswamy, S. & 1 andra, Friemann, R., 2018 dec 1, I : Nature Communications. 9, 1, 1753.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  14. Quinoline-galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain

    Pal, K. B., Mukul Mahanti, Huang, X., Persson, S., Sundin, A. P., Zetterberg, F. R., Stina Oredsson, Hakon Leffler & Ulf J. Nilsson, 2018 aug 3, I : Organic and Biomolecular Chemistry. 16, 34, s. 6295-6305 11 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  15. Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity

    Peterson, K., Kumar, R., Olof Stenström, Verma, P., Verma, P. R., Håkansson, M., Kahl-Knutsson, B., Zetterberg, F., Hakon Leffler, Mikael Akke, Derek T. Logan & Ulf J. Nilsson, 2018 feb 8, I : Journal of Medicinal Chemistry. 61, 3, s. 1164-1175 12 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  16. Rationally Designed Chemically Modified Glycodendrimer Inhibits Streptococcus suis Adhesin SadP at Picomolar Concentrations

    Haataja, S., Verma, P., Fu, O., Papageorgiou, A. C., Pöysti, S., Pieters, R. J., Ulf J. Nilsson & Finne, J., 2018 feb 6, I : Chemistry - A European Journal. 24, 8, s. 1905-1912

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  17. Arynes in the Monoarylation of Unprotected Carbohydrate Amines

    Pal, K. B., Mukul Mahanti & Ulf J. Nilsson, 2018 feb 2, I : Organic Letters. 20, 3, s. 616-619 4 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  18. Galectin-3 type-C self-association on neutrophil surfaces; The carbohydrate recognition domain regulates cell function

    Sundqvist, M., Welin, A., Elmwall, J., Osla, V., Ulf J. Nilsson, Hakon Leffler, Bylund, J. & Karlsson, A., 2018 feb, I : Journal of Leukocyte Biology. 103, 2, s. 341-353

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  19. Monosaccharide Derivatives with Low-Nanomolar Lectin Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine, Sulfur-π, and Halogen Bond Interactions

    Zetterberg, F. R., Peterson, K., Johnsson, R. E., Brimert, T., Håkansson, M., Derek T. Logan, Hakon Leffler & Ulf J. Nilsson, 2018 jan 22, I : ChemMedChem. 13, 2, s. 133-137

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  20. Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands

    Peterson, K., Collins, P. M., Huang, X., Kahl-Knutsson, B., Essén, S., Zetterberg, F. R., Stina Oredsson, Hakon Leffler, Blanchard, H. & Ulf J. Nilsson, 2018, I : RSC Advances. 8, 44, s. 24913-24922 10 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  21. Designing interactions by control of protein-ligand complex conformation: Tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions

    A. L. Noresson, Aurelius, O., Öberg, C. T., Engström, O., Sundin, A. P., Håkansson, M., O. Stenström, M. Akke, D. T. Logan, H. Leffler & U. J. Nilsson, 2018, I : Chemical Science. 9, 4, s. 1014-1021 8 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  22. Galectin-3 is an amplifier of the interleukin-1β-mediated inflammatory response in corneal keratinocytes

    Uchino, Y., Woodward, A. M., Mauris, J., Peterson, K., Verma, P., Ulf J. Nilsson, Rajaiya, J. & Argüeso, P., 2018, I : Immunology. 154, 3, s. 490-499

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  23. Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin–glycan specificities in a natural context

    Nielsen, M. I., John Stegmayr, Grant, O. C., Yang, Z., Ulf J. Nilsson, Boos, I., Carlsson, M. C., Woods, R. J., Unverzagt, C., Hakon Leffler & Wandall, H. H., 2018, I : Journal of Biological Chemistry. 293, 52, s. 20249-20262 14 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  24. 2017
  25. Spindle pole cohesion requires glycosylation-mediated localization of NuMA

    Magescas, J., Sengmanivong, L., Viau, A., Mayeux, A., Dang, T., Burtin, M., Ulf Nilsson, Hakon Leffler, Poirier, F., Terzi, F. & Delacour, D., 2017 dec 1, I : Scientific Reports. 7, 1, 1474.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  26. Galectin-3 inhibition by a small-molecule inhibitor reduces both pathological corneal neovascularization and fibrosis

    Chen, W. S., Cao, Z., Hakon Leffler, Ulf J. Nilsson & Panjwani, N., 2017 jan 1, I : Investigative Ophthalmology and Visual Science. 58, 1, s. 9-20 12 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  27. 2016
  28. Perdeuteration, crystallization, data collection and comparison of five neutron diffraction data sets of complexes of human galectin-3C

    Manzoni, F., Kadhirvel, S., Janina Sprenger, Kumar, R., Ann Louise Noresson, Ulf J. Nilsson, Hakon Leffler, Fisher, S. Z., Schrader, T. E., Ostermann, A., Coates, L., Blakeley, M. P., Oksanen, E. & Derek T. Logan, 2016 nov 1, I : Acta Crystallographica Section D: Structural Biology. 72, 11, s. 1194-1202 9 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  29. Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3

    Chen, W. S., Cao, Z., Sugaya, S., Lopez, M. J., Sendra, V. G., Laver, N., Hakon Leffler, Ulf J. Nilsson, Fu, J., Song, J., Xia, L., Hamrah, P. & Panjwani, N., 2016 apr 12, I : Nature Communications. 7, 11302.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  30. Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition

    Delaine, T., Collins, P., Mackinnon, A., Sharma, G., John Stegmayr, Rajput, V. K., Mandal, S., Cumpstey, I., Larumbe, A., Salameh, B. A., Kahl Knutson, B., vanHattum, H., van Scherpenzeel, M., Pieters, R. J., Sethi, T., Schambye, H., Stina Oredsson, Hakon Leffler, Blanchard, H. & Ulf Nilsson, 2016, I : ChemBioChem. 17, 18, s. 1759-1770

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  31. Low or No Inhibitory Potency of the Canonical Galectin Carbohydrate-binding Site by Pectins and Galactomannans

    John Stegmayr, Lepur, A., Kahl Knutson, B., Aguilar-Moncayo, M., Klyosov, A. A., Field, R. A., Stina Oredsson, Ulf Nilsson & Hakon Leffler, 2016, I : Journal of Biological Chemistry. 291, 25, s. 13318-13334 17 s.

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  32. 2015
  33. Aryl Sulfonates in Inversions at Secondary Carbohydrate Hydroxyl Groups: A New and Improved Route Toward 3-Azido-3-deoxy-beta-D-galactopyranosides

    Peterson, K., Weymouth-Wilson, A. & Ulf Nilsson, 2015, I : Journal of Carbohydrate Chemistry. 34, 8, s. 490-499

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  34. Gal-3 regulates the capacity of dendritic cells to promote NKT-cell-induced liver injury

    Volarevic, V., Markovic, B. S., Bojic, S., Stojanovic, M., Ulf Nilsson, Hakon Leffler, Besra, G. S., Arsenijevic, N., Paunovic, V., Trajkovic, V. & Lukic, M. L., 2015, I : European Journal of Immunology. 45, 2, s. 531-543

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  35. 2014
  36. Synthesis of 1,2,3-triazole-linked galactohybrids and their inhibitory activities on galectins

    Mackevica, J., Ostrovskis, P., Hakon Leffler, Ulf Nilsson, Rudovica, V., Viksna, A., Belyakov, S. & Turksa, M., 2014, I : Arkivoc. 2014, 3, s. 90-112

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  37. 2013
  38. Galectin-3 deficiency protects pancreatic islet cells from cytokine-triggered apoptosis in vitro

    Saksida, T., Nikolic, I., Vujicic, M., Ulf Nilsson, Hakon Leffler, Lukic, M. L., Stojanovic, I. & Stosic-Grujicic, S., 2013, I : Journal of Cellular Physiology. 228, 7, s. 1568-1576

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  39. Investigation into the Feasibility of Thioditaloside as a Novel Scaffold for Galectin-3-Specific Inhibitors

    Bum-Erdene, K., Gagarinov, I. A., Collins, P. M., Winger, M., Pearson, A. G., Wilson, J. C., Hakon Leffler, Ulf Nilsson, Grice, I. D. & Blanchard, H., 2013, I : ChemBioChem. 14, 11, s. 1331-1342

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  40. Tuning the Preference of Thiodigalactoside- and Lactosamine-Based Ligands to Galectin-3 over Galectin-1

    van Hattum, H., Branderhorst, H. M., Moret, E. E., Ulf Nilsson, Hakon Leffler & Pieters, R. J., 2013, I : Journal of Medicinal Chemistry. 56, 3, s. 1350-1354

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  41. 2012
  42. Galectin-3 deficiency prevents concanavalin A-induced hepatitis in mice

    Volarevic, V., Milovanovic, M., Ljujic, B., Pejnovic, N., Arsenijevic, N., Ulf Nilsson, Leffler, H. & Lukic, M. L., 2012, I : Hepatology. 55, 6, s. 1954-1964

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  43. Low-Molecular Weight Inhibitors of Galectins

    Hakon Leffler & Ulf Nilsson, 2012, Galectins and Disease Implications for Targeted Therapeutics. American Institute of Physics (AIP), Vol. 1115. s. 47-59

    Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKonferenspaper i proceeding

  44. Regulation of Transforming Growth Factor-beta 1-driven Lung Fibrosis by Galectin-3

    MacKinnon, A. C., Gibbons, M. A., Farnworth, S. L., Hakon Leffler, Ulf Nilsson, Delaine, T., Simpson, A. J., Forbes, S. J., Hirani, N., Gauldie, J. & Sethi, T., 2012, I : American Journal of Respiratory and Critical Care Medicine. 185, 5, s. 537-546

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  45. The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics

    Kadhirvel, S., Håkansson, M., Genheden, S., Diehl, C., Qvist, J., Weininger, U., Ulf Nilsson, Hakon Leffler, Ulf Ryde, Mikael Akke & Derek Logan, 2012, I : Biochemistry. 51, 1, s. 296-306

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  46. 2011
  47. Identification of a Novel Streptococcal Adhesin P (SadP) Protein Recognizing Galactosyl-alpha 1-4-galactose-containing Glycoconjugates CONVERGENT EVOLUTION OF BACTERIAL PATHOGENS TO BINDING OF THE SAME HOST RECEPTOR

    Kouki, A., Haataja, S., Loimaranta, V., Pulliainen, A. T., Ulf Nilsson & Finne, J., 2011, I : Journal of Biological Chemistry. 286, 45, s. 38854-38864

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  48. Inhibition of Galectins with Small Molecules

    Öberg, C., Hakon Leffler & Ulf Nilsson, 2011, I : Chimia. 65, 1-2, s. 18-23

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  49. N-Substituted salicylamides as selective malaria parasite dihydroorotate dehydrogenase inhibitors

    Fritzson, I., Bedingfield, P. T. P., Sundin, A., McConkey, G. & Ulf Nilsson, 2011, I : MedChemComm. 2, 9, s. 895-898

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

  50. Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries

    Harrison, J. A., Kartha, K. P. R., Fournier, E. J. L., Lowary, T. L., Malet, C., Ulf Nilsson, Hindsgaul, O., Schenkman, S., Naismith, J. H. & Field, R. A., 2011, I : Organic and Biomolecular Chemistry. 9, 5, s. 1653-1660

    Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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