Estrogen receptor and multixenobiotic resistance genes in freshwater fish and snails: identification and expression analysis after pharmaceutical exposure

Projekt: Avhandling


Ämnesklassifikation (UKÄ)

  • Biokemi och molekylärbiologi
  • Genetik
  • Zoologi
  • Miljövetenskap
  • Fisk- och akvakulturforskning
  • Ekologi


Several different pharmaceuticals from societal use e.g. human use and agriculture) are today continuously being released into aquatic environments where they can interfere with wild organisms' biological processes. The general
research objective of this research project was to analyze how aquatic freshwater organisms are affected by exposure to pharmaceuticals that are categorized by
the EU as potential risk factors to the environment (i.e., estrogens, EE2, and diclofenac). We have analyzed the unknown mechanistic actions of EE2 and non-steroidal anti-inflammatory drugs (NSAIDs, such as diclofenac) on
estrogen receptor (er) genes or multixenobiotic resistance (mxr) genes in both common freshwater snails and fish. We identified several new
molecular EE2 targets in freshwater wildlife such as the estrogen receptor (er) genes in aquatic slugs (Bithynia tentaculata, and Radix
balthica) and the fresh water fish roach (Rutilus rutilus). By profiling gene expression responses, we added to the currently limited knowledge on the
mechanistic activities of pharmaceutical compounds in exposed aquatic organisms.

Populärvetenskaplig beskrivning

Organisms that live in aquatic environments are today at risk because of modern society's high use of pharmaceutical compounds. These substances often make their way into the water from sewage treatment plants with insufficient cleaning steps, and leakage from agriculture where livestock are treated with for example antibiotics. How species are disrupted by the pharmaceuticals is difficult to predict but requires attention.
Kort titelPharmaceutical exposure in fish and snails
Gällande start-/slutdatum2010/12/062016/03/18


Relaterad forskningsoutput

Hultin, C., 2016, Lund University, Faculty of Science, Center for Environmental and Climate Research. 103 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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