1-[C-11]-acetate PET imaging in head and neck cancer - a comparison with F-18-FDG-PET: Implications for staging and radiotherapy planning

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1-[C-11]-acetate PET imaging in head and neck cancer - a comparison with F-18-FDG-PET: Implications for staging and radiotherapy planning. / Sun, Aijun; Soerensen, Jens; Karlsson, Mikael; Turesson, Ingela; Langstroem, Bengt; Nilsson, Per; Cederblad, Lena; Bertling, Jan; Riklund, Katrine; Johansson, Silvia.

I: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 34, Nr. 5, 2007, s. 651-657.

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Sun, Aijun ; Soerensen, Jens ; Karlsson, Mikael ; Turesson, Ingela ; Langstroem, Bengt ; Nilsson, Per ; Cederblad, Lena ; Bertling, Jan ; Riklund, Katrine ; Johansson, Silvia. / 1-[C-11]-acetate PET imaging in head and neck cancer - a comparison with F-18-FDG-PET: Implications for staging and radiotherapy planning. I: European Journal of Nuclear Medicine and Molecular Imaging. 2007 ; Vol. 34, Nr. 5. s. 651-657.

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TY - JOUR

T1 - 1-[C-11]-acetate PET imaging in head and neck cancer - a comparison with F-18-FDG-PET: Implications for staging and radiotherapy planning

AU - Sun, Aijun

AU - Soerensen, Jens

AU - Karlsson, Mikael

AU - Turesson, Ingela

AU - Langstroem, Bengt

AU - Nilsson, Per

AU - Cederblad, Lena

AU - Bertling, Jan

AU - Riklund, Katrine

AU - Johansson, Silvia

PY - 2007

Y1 - 2007

N2 - Purpose The aim of this study was to evaluate the feasibility of using 1-[C-11]-acetate positron emission tomography (ACE-PET) to detect and delineate the gross tumour volume of head and neck cancer before radiotherapy, and to compare the results with those obtained using F-18-fluoro-2-deoxy-D-glucose (FDG) PET. Methods Ten patients with histologically verified squamous cell carcinoma were investigated by FDG-PET and dynamic ACE-PET prior to radiotherapy. The two scans were performed on the same day or on consecutive days, except in one patient in whom they were done 5 days apart. Diagnostic CT or MRI was performed in all patients. The image data sets were analysed both visually and semi-quantitatively. All primary tumours and metastases were delineated automatically by using the 50% threshold of maximum radioactivity corrected for background. The mean standardised uptake value (SUV) and the tumour volumes were evaluated and compared. Results All ten primary tumours were detected by ACE-PET, while nine primaries were detected by FDG-PET and CT and/or MRI. The ACE SUV tended to be lower than the FDG SUV (5.3 +/- 2.7 vs 9.6 +/- 7.0, p=0.07). The tumour volumes delineated with ACE were on average 51% larger than the FDG volumes (p < 0.05). ACE-PET identified 20/21 lymph node metastases, while only 13/21 lesions were detected by FDG-PET and 16/21 lesions by CT or MRI. Conclusion ACE-PET appears promising for the staging of head and neck cancer. The biological information provided by both FDG and ACE must be carefully validated before it can be used in clinical routine for radiation treatment planning. More studies are needed to evaluate the differences in volumes and to confirm the clinical potential of both FDG and ACE-PET, especially in radiotherapy.

AB - Purpose The aim of this study was to evaluate the feasibility of using 1-[C-11]-acetate positron emission tomography (ACE-PET) to detect and delineate the gross tumour volume of head and neck cancer before radiotherapy, and to compare the results with those obtained using F-18-fluoro-2-deoxy-D-glucose (FDG) PET. Methods Ten patients with histologically verified squamous cell carcinoma were investigated by FDG-PET and dynamic ACE-PET prior to radiotherapy. The two scans were performed on the same day or on consecutive days, except in one patient in whom they were done 5 days apart. Diagnostic CT or MRI was performed in all patients. The image data sets were analysed both visually and semi-quantitatively. All primary tumours and metastases were delineated automatically by using the 50% threshold of maximum radioactivity corrected for background. The mean standardised uptake value (SUV) and the tumour volumes were evaluated and compared. Results All ten primary tumours were detected by ACE-PET, while nine primaries were detected by FDG-PET and CT and/or MRI. The ACE SUV tended to be lower than the FDG SUV (5.3 +/- 2.7 vs 9.6 +/- 7.0, p=0.07). The tumour volumes delineated with ACE were on average 51% larger than the FDG volumes (p < 0.05). ACE-PET identified 20/21 lymph node metastases, while only 13/21 lesions were detected by FDG-PET and 16/21 lesions by CT or MRI. Conclusion ACE-PET appears promising for the staging of head and neck cancer. The biological information provided by both FDG and ACE must be carefully validated before it can be used in clinical routine for radiation treatment planning. More studies are needed to evaluate the differences in volumes and to confirm the clinical potential of both FDG and ACE-PET, especially in radiotherapy.

KW - head and neck cancer

KW - SUV

KW - PET

KW - C-11-acetate

KW - F-18-FDG

U2 - 10.1007/s00259-006-0298-9

DO - 10.1007/s00259-006-0298-9

M3 - Article

VL - 34

SP - 651

EP - 657

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

SN - 1619-7070

IS - 5

ER -