2015/16 seasonal vaccine effectiveness against hospitalisation with influenza a(H1N1)pdm09 and B among elderly people in Europe: Results from the I-MOVE+ project

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We conducted a multicentre test-negative case–control study in 27 hospitals of 11 European countries to measure 2015/16 influenza vaccine effectiveness (IVE) against hospitalised influenza A(H1N1)pdm09 and B among people aged ≥ 65 years. Patients swabbed within 7 days after onset of symptoms compatible with severe acute respiratory infection were included. Information on demographics, vaccination and underlying conditions was collected. Using logistic regression, we measured IVE adjusted for potential confounders. We included 355 influenza A(H1N1)pdm09 cases, 110 influenza B cases, and 1,274 controls. Adjusted IVE against influenza A(H1N1)pdm09 was 42% (95% confidence interval (CI): 22 to 57). It was 59% (95% CI: 23 to 78), 48% (95% CI: 5 to 71), 43% (95% CI: 8 to 65) and 39% (95% CI: 7 to 60) in patients with diabetes mellitus, cancer, lung and heart disease, respectively. Adjusted IVE against influenza B was 52% (95% CI: 24 to 70). It was 62% (95% CI: 5 to 85), 60% (95% CI: 18 to 80) and 36% (95% CI: -23 to 67) in patients with diabetes mellitus, lung and heart disease, respectively. 2015/16 IVE estimates against hospitalised influenza in elderly people was moderate against influenza A(H1N1)pdm09 and B, including among those with diabetes mellitus, cancer, lung or heart diseases.


Externa organisationer
  • Epiconcept, Paris
  • Carlos III Health Institute
  • CIBER Epidemiology and Public Health (CIBERESP)
  • Navarre Public Health Institute (ISPN)
  • Istituto Superiore di Sanità
  • Carol Davila University of Medicine and Pharmacy
  • Institut Gustave Roussy
  • National Institute for Health and Welfare
  • Lithuanian University of Health Sciences
  • Croatian National Institute of Public Health, Zagreb
  • National Institute of Public Health-National Institute of Hygiene, Poland
  • National Institute for Public Health and the Environment (RIVM)
  • INC Cantacuzino
  • Hôpital Saint Eloi
  • Hospital Universitario Donostia
  • General de Salud Publica
  • Paseo Isabel la Católica
  • Hospital of Navarra, Pamplona
  • Hospital de Tudela
  • University of Bari Aldo Moro
  • Azienda Ospedaliera Universitaria San Martino IST
  • University of Siena
  • National Institute of Research Cantacuzino
  • Hospital Estella
  • National Institute of Health Dr. Ricardo Jorge

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Infektionsmedicin
Utgåva nummer30
StatusPublished - 2017 jul 27
Peer review utfördJa
Externt publiceradJa