4-Hydroxy-N -[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: A novel inhibitor of the canonical NF-κB cascade

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Bibtex

@article{585b1a4612b4464ea2bc3810d800a245,
title = "4-Hydroxy-N -[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: A novel inhibitor of the canonical NF-κB cascade",
abstract = "The NF-κB signaling pathway is a validated oncological target. Here, we applied scaffold hopping to IMD-0354, a presumed IKKβ inhibitor, and identified 4-hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide (4) as a nM-inhibitor of the NF-κB pathway. However, both 4 and IMD-0354, being potent inhibitors of the canonical NF-κB pathway, were found to be inactive in human IKKβ enzyme assays.",
author = "Pippione, {Agnese C.} and Antonella Federico and Alex Ducime and Stefano Sainas and Donatella Boschi and Alessandro Barge and Elisa Lupino and Marco Piccinini and Michael Kubbutat and Contreras, {Jean Marie} and Christophe Morice and Salam Al-Karadaghi and Lolli, {Marco L.}",
year = "2017",
doi = "10.1039/c7md00278e",
language = "English",
volume = "8",
pages = "1850--1855",
journal = "MedChemComm",
issn = "2040-2511",
publisher = "Royal Society of Chemistry",
number = "9",

}